Conserved Protein Domain Family
CSTF1_dimer
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pfam16699: CSTF1_dimer (This model is not part of the current CDD release)
Cleavage stimulation factor subunit 1, dimerization domain
This family is the dimerization domain, at the N-terminal, of a family of cleavage stimulation factor subunit 1 proteins from eukaryotes. This domain allows for homodimerization such that the functional state of CSTF1 is a heterohexamer. The cleavage stimulation factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing. CstF recognises U and G/U-rich cis-acting RNA sequence elements and helps to stabilise the cleavage and polyadenylation specificity factor (CPSF) at the polyadenylation site as required for productive RNA cleavage.
Links
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Statistics
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PSSM-Id: 522506
Aligned: 19 rows
Threshold Bit Score: 76.5335
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7QCR7        11 NLLKCREQLYRMMISQLFYDGYHSVAVELTNLVR-ADPPCPPSDRLMNIFKQANQIEQ 67  Anopheles gambiae str. PEST
EDS27300      12 NVVKCRELLYRLMISQLFYDGHHQLAVELTGLVR-ADPPCPPSDRLLNIFRQASQIDS 68 
XP_032227362  31 EAIKQRETLYKLIISQLHYDGCEAVAAALAKTTN-IISPCPPCARLLEIVNLGLAAEA 87 
XP_002113420   3 EIVKNREQLYKLIISQLRYDGYEDIAALVGNTVN-TLETCAPSSKLFNIVSRSLSSES 59 
XP_018649969   1 mSFKERDLLYRLIISQLFYDGFQTMAVNLVNLVS-PSAACGPSNRLFRLVKLGLSASE 57 
3_pfamImport   1 MCIKNRDHLYRLIISQLFYDGHSTIASSLAAQVN-ADPPCSPSDRLMSVVTKGLQHET 57 
5_pfamImport   1 NLLKNRELLYRLIISQFLYDGLEKIAKEVQMIVK-ADPDCAPSEQLLHFMIAGMQLE- 56 
XP_002126933   2 DAIKKRERMYRSIIGQLQNDGYMAIAKSLTSQVK-PFNPCTSSDFLFKAYSIGLEQVE 58  vase tunicate
NP_495822      3 PDIKDREYMYRLIIGQLFYDGHQQIAVNLANTLGcSAPAPPPSDKLFRLVTIAKQFVE 60  Caenorhabditis elegans
XP_024350963   1 MSIRERDVLYRLIISQLFHDGYQAIAINLMNEVS-PTISCGPSARLLKLVKLGLSIAD 57  Echinococcus granulosus
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