Conserved Protein Domain Family
Folliculin_C

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pfam16692: Folliculin_C (This model is not part of the current CDD release)
Folliculin C-terminal domain
This is the C-terminal domain of folliculin. It has guanine nucleotide exchange factor (GEF) activity.
Statistics
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PSSM-Id: 522499
Aligned: 9 rows
Threshold Bit Score: 261.593
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005157956 324 PKFKSLRHLRQVLGTADFRQLTWHVLMGNQVIWRGADPGLIQSAFNVLKALLPVGCVRAVQYSPHYEEAYRCNFLGLSPD 403
XP_014350058 346 AVFRSLRHMRQVLGVSAFRMLAWHVLIGNQVIWRGQNKDLIQSAFDVLKAMLPVGCVRIIPYSDQYEETYRCNFLGLSHE 425
XP_004995234 678 mpaASLSDLCNVLGTDSMRLALHHISIGNQCIVLASQPSVSTAIAQLLACTLPDRCVSLNVNQREYVPTYACNILGMSGA 757
XP_004366348 380 ERVESLGQVCKIVGEASVSALIYNVVVGNQVLVRGQNAALVGSLINCLVDLAPSECMTVCMYSETFKEIWECNIVGLAPN 459
Q54UF2       441 ELILSLSQVNRIMGEDAFSILVYNIIIGNQVIIRGQNERLVTSMVSVVKEILPKECVNVCNFSNTFKELWECNILGLNTS 520 Dictyostelium d...
XP_003293101 516 ELITSFGQIHRIMGEDAFSILIYNLIIGNQVIIRGSSEILVKSMVDIIKELLPTECVTACDYSDTFKEQWECNILGLNSI 595
2_pfamImport   1 PIFKSLRHMREVMQPHWFKAIAWHLLIGNQVVWKGDDKELITSALNVLKDLLPHGCVKLLTNSDQYVNCSKANLLGLTEA 80 
XP_003977665 325 PKFRSLRHLRQVLGAAEFRQLVWHVLMGNQVIWRGAEPSLIQSAFIVLKSLLPVGCVRSIPFSAQYEEAYKCNFLGLSPD 404 torafugu
XP_018669825 330 PIFTSLRHMREVLQPPLFKAIAWHLVVGNQVIWKGQDQDLITSALVVLKQLLPVGCVKMQTRSDKYLNSYKANLLGLTEK 409 vase tunicate
XP_005157956 404 VPIPA-HVSSSEFSVLVDVLSAER-----GCVNPV--SD-DDILSLYQFH-ISSANTQPtdK-GPTL---LNKLEVALSN 469
XP_014350058 426 VQIPP-HIVTSEFCVLVDVHPATR-----SNLYPVlfVD-EEPLSKYEFE-VISGSSVAtdR-GPTI---LNKIEAALMN 493
XP_004995234 758 GSLPD--DLASKGAVLLRIHTAVEamt--------dgADgADADVDEDWP-FYAPIKRVdvEgSPGPdghVNTFVTAVLE 826
XP_004366348 460 VVIPR-H-VDRTVIAIVDIDYYDSskepeDIDHPDr--------sTIEIS-FSGPk-------YTSS---MGSAIEYVIL 518
Q54UF2       521 AVIPL-H-IDKDICCIVDIDYYDLskepdDIDHPNr--------sTIEIT-CSGSk-------FPST---LGIAIESIYK 579 Dictyostelium d...
XP_003293101 596 AVIPR-H-IDKETTSIVDIEYYDKskepeDIDHPNr--------sTIEIT-CIGPk-------HPST---LGLAIESIYK 654
2_pfamImport  81 AIIPAlNVRCSENFILVETVRKNHpk--sNQLYPSleP--GNIMNGVEFK-VTNRCVIP--EkGPEI---LNKLEVAIAN 150
XP_003977665 405 VPIPT-HVSSSEFSVLVD-VSSEA-----SCQNSA--VAnDDVSTLHQFTiSSANTQPAd--rGPTL---LNKLEVALSN 470 torafugu
XP_018669825 410 ACVPS-HVKSAEHFILIHVLRKNNngqkfSHIYPSlpPN-NNSMNGIEFR-VTNSCILP--EkGPEM---LNKVEVAIAN 481 vase tunicate
XP_005157956 470 EN---LSVEVVSLCLLCLKEEWMNKVKVLFKFSKVdgRGKEDTQKVLALLGATgp-gEEDNVRLLKFWMTGLSKLYKSHL 545
XP_014350058 494 EN---LSGEVVDQCLICLKEEWMNKVKVLFKFTKVdsRPKEDTQKLLSILGAA----EEDNVKLLKFWMTGLSKTYKSHL 566
XP_004995234 827 ASerpHDPELSVELLRALREKYTRIAKMYFALTR---GKKVPPYRALQVLGL-----PPQDQQLLMFWTSALSPTQRrvi 898
XP_004366348 519 QN---YPPEVERIHLLNIKEEWINKTKAFYGVRSI--IEDVSDKRLQKFMQIInc-vYEKDIMILMFWTTCVRKQFVYAp 592
Q54UF2       580 QY---CTITLENIQLKSIKEEWINKSKSFYSIKTI--IENEKDKRLFSFLNIInchhFEKDMEILMFWSMCARKWFIQfn 654 Dictyostelium d...
XP_003293101 655 QY---CSTPLENIQLKALKEEWINKSKSFYSMKTI--IEDEKDKRLLSFLNIInc-qFEKDMEILMFWCASLRKWFMDNK 728
2_pfamImport 151 IS---LSAEVVKHCLICMKEEWMNKAKILYKFTMVdnRDKEDTNWLIHECLQC----GDDDLRLLTFWLTALTPQFKEDM 223
XP_003977665 471 EN---LSVDVVSHCLLCLKEEWMNKVKVLFKFSKVdgRGREDTQKVLALLGATgp-gEEDNVRLLKFWMTGLSKTYKSHL 546 torafugu
XP_018669825 482 DS---LSPEVVRHCLICLKEEWMNKVKILYKFTKIdnRDKEETARMLQGCLQC----TDDDVRLLKFWMTGLSSKFKEEL 554 vase tunicate
XP_005157956 546 M 546
XP_014350058 567 M 567
XP_004995234 899 l 899
XP_004366348 593 n 593
Q54UF2       655 k 655 Dictyostelium discoideum AX4
XP_003293101 729 I 729
2_pfamImport 224 R 224
XP_003977665 547 M 547 torafugu
XP_018669825 555 R 555 vase tunicate
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