1DEB


Conserved Protein Domain Family
APC_N_CC
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pfam16689: APC_N_CC 
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Coiled-coil N-terminus of APC, dimerization domain
APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
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Statistics
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PSSM-Id: 435517
Aligned: 5 rows
Threshold Bit Score: 65.3955
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1DEB_A          3 ASYDQLLKQVEALKMENSnLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 54   human
3_pfamImport    1 AAYEQLVRQGEALPRTAT-WRQELRDNSSHLSKLETETSGMKAVLQHLQGKL 51  
KAI2538450      4 ASYDQLLKQVEALKMENSnLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55  
XP_063119242    6 ASYEQLVRQVEALKAENThLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 57   Norway rat
XP_018668496   59 SRYDQLLQQVECLKLENTtLKKELSNNSSQISKLESEALNLKEMVVMLGNSI 110  vase tunicate
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