7UYK


Conserved Protein Domain Family
UBA_HOIP

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pfam16678: UBA_HOIP (This model is not part of the current CDD release)
HOIP UBA domain pair
HOIP-UB is a binding domain on E3 ubiquitin-protein ligase RNF31 like proteins. E3 ubiquitin-protein ligase RNF31 is often referred to as HOIL-1L binding partner. The interaction of HOIL-1L and HOIP is thus via the UBL-UBA interaction. this interaction is important in E3 complex formation and the subsequent activation of NF-kappaB. This family contains two UBA-like domains.
Statistics
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PSSM-Id: 522487
Aligned: 18 rows
Threshold Bit Score: 192.516
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7UYK_A          10 KMREEGLQLVSMIREGEAAGACPEEIFSALQYSGTE--VPLQWLRSELPYVLEMVAELAGQQD----------------- 70   human
XP_005449168   497 MMKEDGLALVHHIREAEKRGMSPEEVYAALCACGGSnvNPCDWLTSELPHLLDEICAMAASVQlnykmgsvgtqpvlerd 576 
3_pfamImport     1 TLTRQGLEVVELLRDAERQGFTTDDVQVALAQGAA---NPLDWLRTQWPHLVETVQVLVAAQGkel-------------- 63  
11_pfamImport    1 KQVTQGLEMVKLLRDAEENQFTADDLAVALTHCEDE--DPILWLQQNWRNMIDTVVTLATNYGher-------------- 64  
XP_001988028   977 PARDPEIEMHIILKELELYKFTVEELEAALKYCGPDm-HPIQWLRENWHKLVQTVQSLSTKYGqer-------------- 1041
12_pfamImport    1 SIKEEPSEMTLLLREAERYQFTAEELQAAMNHCGEK--HPVQWLRDNWNKLIETVQTLATKYGhek-------------- 64  
EDO46475       425 EMLIEGRRYVDLLKTAEINNFLPEELNIAITLSEGMemGPIEWLKTKWFDLIHTVMLRVTEKSk---------------- 488 
XP_023181858   509 TMREDGLVLIHQIREAEKRGVSPEEVYAALSMCGGSsiNPCDWLTSELPHLLDEICAMAASVQltcrpgnggsal----- 583 
XP_006010093   612 QMRARGQKLVQMIREGEKNGVSPEDVYCAVRYSGTE--VPVQWLRTELPHVLETIADLATQKGaam-------------- 675  coelacanth
XP_056719635   468 KLREDGQKMIAMIREAEAVGVVPELVAAALRYSGAE--RPLAWLNSELPCVLEGVAEMATQRGeee-------------- 531  tarantolino
7UYK_A          71 ------------PGLGAFSCQEARRAWLDRHGNLDEAVEECVRTRRRKVQELQSLGFGPEEGSLQALFQHGGDVSRALTE 138  human
XP_005449168   577 ggeseksgptsiGDSMKLSRAEAKLAWLKTGGDTDKAVRELLRDRKEKMKELHSLGFQDVAQCEEALRQSGGEMQGALSL 656 
3_pfamImport    64 ----------keNTVGVLSPAEAKEALRSVKGDVWNAVATAIRRRQRKCEQIMAKGSFALADVVKALDNNAGVEDATLLE 133 
11_pfamImport   65 ----------keNTVGTISASEARDALRLHDGNVWAAVTECVDQRQRKYAELLSRGNFSREDIVTMLTSHHGNVEAAYTE 134 
XP_001988028  1042 ----------aeNTIGTISQNEAREALRSSGGNVWQAVADCIQQRQQKYRKLAAKGNFLSEDIVNALTAHQGNVEQALVE 1111
12_pfamImport   65 ----------reNTIGTISIAEARDALRLHKGNIWRAITECIEQRQRKYREIASKGNFTREDIVTSLTAHHGNLELALVE 134 
EDO46475       489 -----------cADIGNISPEEARQALIEHTGDVEPAVEYCVTQRENKLTKVMDSGIYVRTDCIKELDKSNGDVDRAIRS 557 
XP_023181858   584 lmerdgpeqnaaPGGVKLSRAEAKLAWLAAGGNKDKAVRQLLRDRQVKMRELHSLGFQDMSQCEEALRQSGGDIKGALSL 663 
XP_006010093   676 ----------veNTVGVVRLEEARLAWRACEGNIEDAVQECVTMRRRKFQELKVMGFSDREEVLQSLYINGGDVSKALTD 745  coelacanth
XP_056719635   532 ----------pgGGLGAVTYQEAQTAWTESQGDVDEAVSRCLAARRSKVRELKVLGFAEQAPVLQALYQNKGDVWQALVQ 601  tarantolino
7UYK_A         139 LQRQRLEPFRQRLWDS 154  human
XP_005449168   657 LQRPLLEAFHQRIWTA 672 
3_pfamImport   134 LQRNQLKPFLMRIWGP 149 
11_pfamImport  135 LNKSQLKPFLMRIWGP 150 
XP_001988028  1112 LNRTQLKPFLMRIWGS 1127
12_pfamImport  135 LSKTQLKPFLMRIWGP 150 
EDO46475       558 LELLTLAPFRQRILER 573 
XP_023181858   664 LQRPLMEPFHQRIWLD 679 
XP_006010093   746 LQRKLLEPFHQHIWEE 761  coelacanth
XP_056719635   602 LQRQRLEPFHQRLWEs 617  tarantolino
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