Conserved Protein Domain Family
FOXO-TAD
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pfam16676: FOXO-TAD (This model is not part of the current CDD release)
Transactivation domain of FOXO protein family
TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.
Links
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Statistics
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PSSM-Id: 522485
Aligned: 17 rows
Threshold Bit Score: 48.8493
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015789420 550 NNPLPNDLDLNMdsLQGGL--ECDVDQVIRHELSVE-GNLDFNFESM 593
XP_007255737 584 TDRFPSDLDLDM--FNGSL--DCDVDSIIRSDLMDS-DGLDFNFDAL 625
EEC00496     604 NDPLPHDLDLDLdaVQG-L--HCDVDQVIQHELNVD-GNLDFNFDSH 646
ELK15655     464 QDKMPQDLDLDM--YLENL--ECDMDNII-SDLMNGgEGLDFNFEPG 505
XP_006002823 573 QEKLPSDLD-DM--PIERL--DCDMEYIIRNDLMDG-DSLDFNFDTV 613
XP_006628257 595 QEKLPSDLD-DM--SIERF--ECDMESILHDTLMDG-DSLDFNFDPM 635
A3RK75       567 PERLPSDLD-DM--LIDQLdvECDVERVLHDTLMDG-DALDFNFDPM 609 zebrafish
XP_015134143 489 QDRLPIDLDIDM--YMENL--ECDMDYIINSELMDG-EGLDFNFEPV 530 chicken
XP_029703679 584 QDRLPTDLDIDM--FTENL--DCDVDYIINSDLMDA-DGIDFNFDPM 625 torafugu
XP_046759605 482 QDRFPADLDLDM--FNGSL--ECDVESIILNDFMDS-DEMDFNFDSA 523 chicken
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