Conserved Protein Domain Family
FOXO_KIX_bdg

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pfam16675: FOXO_KIX_bdg (This model is not part of the current CDD release)
KIX-binding domain of forkhead box O, CR2
FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.
Statistics
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PSSM-Id: 522484
Aligned: 16 rows
Threshold Bit Score: 70.154
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003455269 380 APMYGQPSM-GMLRhHTPMETIQENKpVSFQrPVR--GYS-ENNALQSLLTGGPr--YCNKDTvlsqGREPHTLMTQGTn 453
XP_005454675 430 NSIFGPHTAgSSLR-SSPMQTIQENKqTSFS-SISttRFG-T-QTLQDLLNSDS---HNHSDVm---MTQSDPLMSQASa 499
XP_007255737 412 NSIFGPST--AGLR-QTPMQTIQENKqTSFS-SIS--HFG-N-TTLQELLNLESlgtHNHSDVm---MTQSDPLISQTS- 479
XP_006626029 427 NSIFGTPSL-TGLR-QSPMQTIQENKqATFS-CIS--HFG-N-QTLQDLLSSDS---HSHSDVm---MTQSDPLMSQAS- 492
XP_069051601 375 GSVYSPPSL-AMLRhHSPMQTIQENKpASFQgGMR--SYS-SSNALQDLLTGGSq--YCPRm-----GQDGDSLMAPTSt 443
3_pfamImport   1 GTIYSQPAM-SLMR-RLPMQTIQENKqASFA-PMH--SYR-N-SSLQDLLSSVS---YAHKES--------DSHMPQASs 62 
NP_001419944 328 GSIYSQPAM-GMMR-RLPMQTIQENKqAVYP-PGS--TYR-N-SSIQDLLSAMS---YGHKDS----LGQSDPGLTN--- 390
Q66JJ0       402 KYSYAQTGM-NPVS-QMPMQTVPENK-SGYR-AVG--QYPvPAGLLKELLTSDS---PPHNDI----LTPVDSAVSQAN- 467 tropical clawed...
XP_006002823 402 KYSYGQTSM-NSLP-QMSMQPLQENK-TSYR-SVS--QFGyPAGLLKELLTSDS---PPHSDI----LPPVDTGISQPK- 467
XP_003969118 381 GPRYTQSSM-GMLQhHTPMETIQENKpVNFQhPIR--GYS-ENNALQSLLTGGPp--YCSKDPg--lGQEPHTLLTQGSt 452 torafugu
XP_003455269 454 GIHSQHNH--NQNRSH 467
XP_005454675 500 TALISQNS--RRGLML 513
XP_007255737 480 AAVTSQNSrlRNGLML 495
XP_006626029 493 TSVSSQSS--RRNIML 506
XP_069051601 444 GV-GSQSH--SQNHNH 456
3_pfamImport  63 MGPPPRSH--RPNVLM 76 
NP_001419944 391 VLGPQRSH--RQNIGM 404
Q66JJ0       468 SRVLAQNSlmAPSSVM 483 tropical clawed frog
XP_006002823 468 ---ICTSAmmATSSVM 480
XP_003969118 453 SVHSPQGH--NQNRGH 466 torafugu
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