Conserved Protein Domain Family
NEXCaM_BD
?
pfam16644: NEXCaM_BD (This model is not part of the current CDD release)
Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
NEXCaM_BD is a coiled-coil domain found as part of the regulatory, C-terminal region of the 12-14 TM sodium/proton exchangers (NHEs)2 of the solute carrier 9 (SLC9) family in all animal kingdoms. The C- lobe of CaM binds the first alpha-helix of the NHE, or NEXCaM_BD region, and the N-lobe of CaM binds the second helix of NEXCaM_BD.
Links
?
Statistics
?
PSSM-Id: 522459
Aligned: 16 rows
Threshold Bit Score: 88.9952
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_031814664 571 STGFMIPLQAQR-----IQGTK-RLSP------EDVKSMRDILTHNMYQVRQRTLSY-NKYNLSTETSEKQAKEILIRRQ 637
XP_023806384 568 AAPSIISLQEEK-----KNSTK----PkkkflaADLKNMHDILSKNMYKIRERTVSYtSKHALP---NDNQRREILIRRH 635
5_pfamImport   1 AAPSLVSLQGEK-----KESTT----PkktfmaEDLKNMHDLLSKNMYKIRQRTVAFtSKHALP---NDNQPREILIRRH 68 
XP_005457888 567 AAPSIVSLYEEK-----KSSSK----PqkkflaADLKNMHDILSKNMYKIRERTVAYrGKHALP---NDNHTREILIRRH 634
3_pfamImport   1 AMPSTVSMQNIQprpptKPAAE-RAIPql--skTKEEEIRKILRTNLQRTRQRLRSY-NRHTLVADPYEDGLSDLFLKKQ 76 
XP_030134737 578 KVPSSVSLSDYH-----EGKIK-PLSP------TEMENMREILTKNLYQIRHRTMSY-NRHSLAADASEKQAKEILIRRR 644
6_pfamImport   1 TVPSFASLNDCR-----EEKVR-KLTP------GEMDEIREILSRNLYQIRQRTLSY-NRSTGVVLSRERLQPEDCLKML 67 
XP_002691231 573 TVPSFASLNDCR-----EEKVR-KLTP------GEMDEIREILSRNLYQIRQRTLSY-NRHNLTADTSERQAKEILIRRR 639
XP_008114344 561 TVPSLASFSELQ-----EEEKRiPSYP------ALTDDIRDILTKNLYQIRQRTPSY-NRYSLAEDANEKQAKEILIRRR 628
EDL99169     566 SVASPTPYQSER-----IQGIK-RLSP------EDVESMRDILTRNMYQVRQRTLSY-NKYNLKPQTSEKQAKEILIRRQ 632

XP_031814664 638 HTFRESLRKGNSLPwGKPSGIKNIRYLSFPYSNPHSANRETGT 680
XP_023806384 636 SSIRRSLRPGSFQT-RQQIVPKSQKYFSLPPGESLNSRFPPTR 677
5_pfamImport  69 ANIRRSLRHGSFQS----TIPRSQKYFSLPTGQNLGSKYSSVR 107
XP_005457888 635 VSIRRSLRPGSFQS--SSYVPRTHKYFSLPAGKSLESTFPAAR 675
3_pfamImport  77 KMFQIEKKV--------------IFNLASPQSPDSVNLLDEFG 105
XP_030134737 645 HSLRESLRKTNSLSrERPAAANTKRFLSLPKNTKLPEKLRVRN 687
6_pfamImport  68 HFMCEMWQHQLKVKeTRQASTSTSRYLSLPKNTKLPEKLQKKK 110
XP_002691231 640 HSLRESIRKDSSLNrEHRASTSTSRYLSLPKNTKLPEKLQKKK 682
XP_008114344 629 HSLRESIRKSNSLS--RPPASKAPRYLSLPKNTKLAEKVRKRN 669
EDL99169     633 NTLRESLRKGQSLPwVKPAGTKNFRYLSFPYSNPQPARRGARA 675
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap