Conserved Protein Domain Family
23ISL

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pfam16620: 23ISL 
Unstructured linker between I-set domains 2 and 3 on MYLCK
23ISL is a natively unstructured region lying between the second and third I-set domains on higher eukaryotic myosin light chain kinase (MYLCK) proteins. The function is not known. It carries a highly conserved TSSTITLQ sequence motif which might be a binding domain.
Statistics
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PSSM-Id: 495974
Aligned: 15 rows
Threshold Bit Score: 180.786
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003207733  273 ENSDFKQATSngiaKELKSSSTELMVETKDRVSAKKETFYISREAKDVKQGQNQEANVAPLQESRGTKAPqVLQKTSSTI 352 
9_pfamImport    1 AGTDIRKEVT----QGSKPDGLAAAAEDKNRPSTQQGGSLTWATGSQPQPPRESDLEPLGDSPRKGQRTP-VLQKTSSTI 75  
2_pfamImport    1 ASSDIRKEVAngvtPGPKLDSLGAAAESKNCSSAQRGGPPAWAPNSQPPPLREPKLELPGDSPRKAPRTP-ILQKTSSTI 79  
8_pfamImport    1 TSSDLRREVTngiaKGPKLDSLETAAESKNCPSPQRGGPPSWATNSQAPPQRESQPEPSRDSLRKGSQNP-VLQKTSSTI 79  
7_pfamImport    1 TSSDIRREVTngisKGLKPDSLETAAGNKNCSSPQSAGSPAWTTNSQPQALRESKLEQCGDPPRAALQAP-VLQKTSSTI 79  
Q15746        267 TNSDVRKEVTnvisKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTP-VLQKTSSSI 345  human
5_pfamImport    1 PDADMRREVTngikKGLKLDSLETMAGSKNSSSLQKGGSLAWVTNSPSHSLWETEPEPCRDSPRK-------VQKTSSTI 73  
6_pfamImport    1 LDADIKREVTngitKGLKLDSVESMARSKTNPSLDKGGCQAQVSNSPSHSLWEPKPELCADSSRKVLKTP-VLQKTSSTI 79  
NP_001099344  270 PSPDIRKEVTngisKDP-----ETVAESKNCSSPQKSNFLAQATNSHLKSLQQPKLKPCEDSPRKVLQSS-VLQKTSSTI 343 
4_pfamImport    1 ANTNIRREVTngiaKGPKLDSLETAAGSKNCSSAQRDVSATCVTDSQPQPLRESKLEPIRDLPRKALRTP-VLQKTSSTI 79  
XP_003207733  353 TLQAVKVQPEPKAEPQTTFIRQAEDRKRtvqPLMTTQENPSlTGQASPRSREAENRAGARKTVKEEKREPL 423 
9_pfamImport   76 TLQAAKVQLEPRAPVPGTPCPSREEREE---PAVAAPDALP-TRRSGLGSQDTMGKVATRKVPMESQRDTT 142 
2_pfamImport   80 TLQATRVQPEPRAPDPGTLLPSGEARER---PAAPPAATLP-TRQSVLGTQDVGNKVASRKIPTESRRDST 146 
8_pfamImport   80 TLQAMKAQLEPKASVSGALSSSEEERKR---PSAPHPVTLP-TRLSGVGSQDTVSKAATRKIPLDSRRDLT 146 
7_pfamImport   80 TLQATRVQPETRVPVLRALSPSGEERKR---PAALHPATVL-TRHSGLGNQEAVDKVANRKILMESQRDSA 146 
Q15746        346 TLQAARVQPEPRAPGLGVLSPSGEERKR---PAPPRPATFP-TRQPGLGSQDVVSKAANRRIPMEGQRDSA 412  human
5_pfamImport   74 TLQATKVQPEPRAPTLGALSPSGEEQKR---PAASQPATHP-TSWSGLESPEVVSTVATRKTPMESQREST 140 
6_pfamImport   80 TLQATKVQPEPRAPALEALSPSREEKRR---LATSQPTTSP-TTRPSPENPEVVSTVATRKTPVESQKEWT 146 
NP_001099344  344 VLQASKVQPEVRAAGIGASGP-GEERKS---LTAPRQATPP-TRQCGLGG-SVGNKFITGNIPIENQRESR 408 
4_pfamImport   80 TLQAAKAQPEQQAPASGALCPSREERKR---PAAPPPATLH-ARQPDLQSQEGVSKVAVRKIAMESWRDST 146 
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