Conserved Protein Domain Family
HECW_N
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pfam16562: HECW_N (This model is not part of the current CDD release)
N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
HECW_N is a domain on E3 ubiquitin-protein ligases that lies upstream of the C2 domain; its function is not clearly understood, except perhaps to determine the substrate spectrum of the ligase.
Links
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Statistics
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PSSM-Id: 522405
Aligned: 5 rows
Threshold Bit Score: 200.096
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_020568121   64 RSTSDTDLVSPDARSTLTVSTSHYTIgqSEDLVISWDIKEEVDAGDWIGMYQVDEVLSENFLDYKNRGISGSHK--GQIV 141 
XP_002110733   10 STSDQANLVIDQEISTLSISTNEVAI--GSSIIISWDIKGPCLENDWIGLFYSDDDNTDNSIACFHRYKDVYRK--GKYS 85  
1_pfamImport    1 RANSDTDLVTSESRSSLTASMYEYTLgqAQNLIIFWDIKEEVDPSDWIGLYHIGESMK---WTCKSRNVKGCQQpgGRIL 77  
XP_005989554   45 RANSDTDLVTSDSRSSLTASMYEYTLglSQNLIIYWDIKEEVDPTDWIGLYHIDENSPANVWDSKNRGVNGTQK--GQIV 122 
XP_011604532   88 RANSDTDLVTSDSRSSLTASTYQLTLghGH-LVIFWDIKEEVDATDWIGLYHIDETCVANMWDSKNRGVNGTQR--GQIV 164  torafugu

XP_020568121  142 WKI-DSSSNFRDVETQVCFRYYHGVTGALRATTPSVTIKKSAA 183 
XP_002110733   86 WLVrEFDNEFGKATSQCCFRYYNSTSQILRAVSPVFTVYNPNV 128 
1_pfamImport   78 VRV-HPTSYFFPTEIKICFKYYHGISGALRATTPCITVKNPAV 119 
XP_005989554  123 WRI-EPGPYFMEPETKICFKYYHGVSGALRATTPCITVKNPAV 164 
XP_011604532  165 WRL-EPGPYFMESETKICFKYYHGISGALRATTPCITVKNPGV 206  torafugu
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