Conserved Protein Domain Family
GIT_CC
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pfam16559: GIT_CC (This model is not part of the current CDD release)
GIT coiled-coil Rho guanine nucleotide exchange factor
GIT-CC is the coiled-coil region of GIT (G protein-coupled receptor kinase-interacting) proteins. This coiled-coil region is the surface that associates with the equivalent binding-region on beta-PIX, or p21-activated kinase-interacting exchange factor proteins. Both GIT and PIX complex together to form a scaffold for the formation of multi-protein assemblies. On its own the GIT-CC region assembles into a parallel two-stranded CC in the asymmetric unit. Similarly the PIX coiled-coil region assembles into a trimer. At least in vitro the two regions associate together into a stable heteropentameric complex that consists of one PIX trimer and one GIT dimer.
Links
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Statistics
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PSSM-Id: 522403
Aligned: 11 rows
Threshold Bit Score: 64.4029
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_020303742 442 KSDDSgDLLQetGPVMIDDFLELKEKVANAESTLTAVQQANTQILRMLTHLQSSVDRLNADNADVHDE 509
4_pfamImport   1 KSLDS-DQSD--GPVTVQDFLEVKNALLASEAKIEQLMKANVSLTEELRLLQKKLLSLQSENSSLRSQ 65 
EHB04762     468 KSLDS-DLSD--GPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSSLRKQ 532
XP_011614053 413 KSLDS-DLSD--GPITMQEYVDLKNALTASEVKIQHLMKANNNLSDELRLMQKKLHTLQSENSSLRRQ 477
XP_046454319 419 KGLQDlNQQK--SGVSVEAYIGIKEQLSLSNVRMQELLASNTNMQTQIAQLQNMVQTLVQENNQLKTQ 484
EDO44131     412 KGTSTsFVLE--DTVPMENYLELKRALATAEARIQQLLQVNASMSQGIQELQSVQIPLAPNEDDDDDD 477
XP_025764717 417 KSSESsDLSD--GPITVQEFMEVKSALTASEAKIQQLLKVNCHLSEELRLMQSKLNSLQTENTTLRWQ 482
XP_040052397 414 KSQDS-ELSD--GPITIHEYMEVKTALSASEAKIQHLLKANNNLSDELRLMQKKLQSLQTENTSLRRH 478
XP_011522986 418 RSMDSsDLSD--GAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQP 483 human
NP_989627    407 RSMDSsDLSD--GPITLQEYLEVKKALAASEAKVQQLMKVNNSLSDELRRLQREIHKLQSENTQIRQQ 472 chicken
XP_029700210 415 kSMDSsDLSD--GPITLQEYLEVKKALASSEAKVQQLMKVNNNLSEELRRLQK--EVRKG--SPGGpa 476 torafugu
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