4CPG


Conserved Protein Domain Family
SGTA_dimer

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pfam16546: SGTA_dimer (This model is not part of the current CDD release)
Homodimerization domain of SGTA
SGTA_dimer is a short N-terminal domain at the start of SGTA or small glutamine-rich tetratricopeptide repeat-containing proteins. It is the homodimerization domain of the SGTA, a heat-shock protein (HSP) co-chaperone involved in the targeting of tail-anchor membrane proteins to the endoplasmic reticulum. This N-terminal homodimerization domain mediates the association with a single copy of Get4 or Get5 proteins, providing a link to the rest of the GET pathway.
Statistics
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PSSM-Id: 522395
Aligned: 75 rows
Threshold Bit Score: 55.2084
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4CPG_A        20 RLAYAIIQFLHDQLRHGGLSSDAQESLEVAIQCLETAFGVTVeDSDLAL------PQTLPEIFE 77  human
XP_013022670   5 KVATAVIDFLNQATATSAVSDEEKESLEVAAQCIKDSFKVEPnEITPGS------GKRLVDAYE 62 
2_pfamImport   4 NLIVAFLQFIRAKSGQGPISQEQAETLEIAIQCLEGTFNIDDgSYAFQP------SRPLIDLFT 61 
Q21746        25 NLVVSFLQFIRQKVSQNQATAEQAEALEVAIQCLEHSFGLDDaSYAFQP------SRPILELFK 82  Caenorhabditis elegans
XP_002198289   6 RLAFSIIQFLHTQLQSGSMSPDAQESLEVAIQCLETAFGVSMeDQSLAV------SQTLPEIFE 63 
6_pfamImport   4 RLAYSIIQFLHDQLQSGGLSSDAQESLEVAVQCLETAFDVSTdDQSLAV------PVTLPEIFA 61 
5_pfamImport   4 RLAYSIIQYLHDQLQHGDLSPDAQESLDASIQCLETAFEVTVeDKYLAV------SQTLPEMFE 61 
XP_029836244   6 RLVLSIVQFLRQQLQTADLSSDAKESVEVAVQCLETAYGVSIdDLSNDSll---vSRTLLDIFR 66 
Q1HQM2         8 FFVRSFIRFLNGQLEQPNFSSDSRESLEVAIQCLENVYEIGQeAEGDNSqenplnHIDLFEVYR 71  yellow fever mosquito
KAF8362993    37 NLAVSFIQFIRHKVSANQCTDDQIEALEVAVQCLESAFALTDaNYAFQP------SKSLLALFT 94  Pristionchus pacificus
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