3VHX


Conserved Protein Domain Family
MKLP1_Arf_bdg
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pfam16540: MKLP1_Arf_bdg (This model is not part of the current CDD release)
Arf6-interacting domain of mitotic kinesin-like protein 1
This family is a C-terminal region of mitotic kinesin-like proteins that is necessary for the interaction with the small GTPase Arf6. MKLP1 is a Flemming body-localising protein essential for cytokinesis, so its interaction with Arf6 shows how Arf6 is involved in cytokinesis. The Arf6-MKLP1 complex plays a crucial role in cytokinesis by connecting the microtubule bundle and membranes at the cleavage plane.
Links
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Statistics
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PSSM-Id: 522389
Aligned: 21 rows
Threshold Bit Score: 138.223
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3VHX_B        12 PPIRLR-HRRSRSA--GDRWVDHKPASNMQTETVMQ----PHVP-H---AITVSVANEKALAKCEKYMLTHQELASDGEI 80  human
XP_048580636 722 PPIRAKqHRRSKSS---DCWIEHKPPCHLDTDTILQ----PFMKnk--kTVSRPDQKDFKTTNATNYCLVDQEEDSSGEI 792
XP_002108127 688 REVKKY-LRRSQPS---DIWLEHKPDENVDEGIIFQidtlLQLNlRkkkTVETPKVNDFAKAQANHYVLEHQEEDSQGEI 763
XP_003384468 720 LYTKGK-AQRKRSL--SENWLEHKPTDCVENNDILQ----PRFKkk--kTVTNPKPKHFKSQNVDKYVLKHQEQDPSGDV 790
Q9PUU5       709 PPVRPL-HRRSHSAg-GERWVDHKPTTNVDLDTVMQ----PNIPn----AIKVNAPNEKALSKCDKYVLTHQEVASDGEI 778 zebrafish
4_pfamImport   1 PPIRLR-HRRSRSAg-GERWVDHKPPSNVEIDTIMQ----PQIPn----AIKVAVPNEKALAKCDKYLLTHQELASDGEL 70 
XP_034516649 707 PPVRLR-HRRSRSA--GDRWVDHKPASNVQTETVMQ----PHVPh----AITVSVANEKALAKCEKYMLTHQELASDGEI 775
XP_046449405 724 PVVSTR-KRRSRSVdpGKGWIDHRPENTLETDTVFQ----PQMN-RaksITKLVDSKTITDPKVSKYVLTTQEQDSSGEI 797
XP_011608280 721 lPVHPL-HRRSHSAg-GEKWVDHKPPCNLDLDTVLQ----PIIPn----AIKVSTPSEKALSKCQKYVLRHQELASDGEI 790 torafugu
XP_011605716 728 TPVRPL-HRRSRSAg-GEKWVDHKPSFNMDLGTVLQ----PVIPn----AIHVSAPNEKVLSKCDRYVLTHQEVASDGEI 797 torafugu

3VHX_B        81 ETKLIKGDIYKTRGGGQSVQFTDIETLKQESPNGS 115 human
XP_048580636 793 ATKIIKGDVYKTAGGGHSIQFTAIETLKERLQGNM 827
XP_002108127 764 ETQLIKGDVFETETGGHSVHFTDVEVLQKRKSIEI 798
XP_003384468 791 KTELYKGDILFTRTGGASVKFTDIEKLDHVSPKPS 825
Q9PUU5       779 QTKLIKGEVFKTRGGGQSVQFTDIETLKQETPVAA 813 zebrafish
4_pfamImport  71 ETKLIKPVLLKLETGITSLLLTKLNNLKVKHYIVI 105
XP_034516649 776 ETKLIKGDVYKTRGGGQSVQFTDIETLKQESPTGR 810
XP_046449405 798 ETKLYKGDVLTTVGGGAQVVLQDVEILRHSSPTAA 832
XP_011608280 791 ETKLIKGNVFKTRGGGQAVQFVDIETLKQECPTAp 825 torafugu
XP_011605716 798 ATKLIKGDVIRTRGGGQAVQFTDIETLKQELATAp 832 torafugu
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