pfam16533: SOAR (This model is not part of the current CDD release)
STIM1 Orai1-activating region
SOAR is the Orai1-activating region of STIM1, where STIM1 are calcium sensors in the endoplasmic reticulum. As the store of calcium is depleted the calcium sensor in the ER activates Orai1, a Ca2+-release-activated Ca2+ (CRAC) channel, in the plasma membrane. The SOAR region, which runs from residues 340-443 on human STIM1, forms a dimer, and is essential for oligomerisation of the whole of STIM1.