8DDR


Conserved Protein Domain Family
TRPM_tetra
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pfam16519: TRPM_tetra (This model is not part of the current CDD release)
Tetramerisation domain of TRPM
TRPM7_tetra is a short anti-parallel coiled-coil tetramerisation domain of the transient receptor potential cation channel subfamily M member proteins 1-8. It is held together by extensive core packing and interstrand polar interactions. Transient receptor potential (TRP) channels comprise a large family of tetrameric cation-selective ion channels that respond to diverse forms of sensory input. The presence of cytoplasmic domains that direct channel assembly appears to be a feature of many voltage-gated ion channel superfamily members.
Links
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Statistics
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PSSM-Id: 522373
Aligned: 13 rows
Threshold Bit Score: 67.4072
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8DDR_A        1216 DERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERL 1271 house mouse
9_pfamImport     1 KNRIKVTAERTEEMCMMVGEVSEKVNFIQDNLSELDSQLGHLQDLSALAVDTLTFL 56  
6_pfamImport     1 IKKIRAIAERAEEMSVMVGEISEKVNCIQHSLSELDCQMGQLQDLSALAVDTLTLL 56  
3_pfamImport     1 INRIRATAERAEEMCTMVGEVSEKVIFIQDSLLDLDCQLGQLQDLSALAVDTLTLL 56  
11_pfamImport    1 VHRIKTTLEKVEEMCLQLKDVAEKVFFVKETLQSLDNQLGHLQDLSALTVDTLSVI 56  
2_pfamImport     1 EERVKVTTDRVENMYQKIEDIDKKESTQNASLQTVEFRIRKLEELSQQTVAHLGVI 56  
10_pfamImport    1 DERIKQTTDRVENMYQKIEDINHKENSQTASIQALEFRLRKLEELSEQTASTLSVI 56  
XP_002423257  1096 DERIKTTTEKVENMYQKVEDINQKENAQTTSIQSVEFRLRKVEDVAEQILNHLDVV 1151
1_pfamImport     1 EERIKMSLEKTENIQQKVDDINQKENLQNSSVQALEFRLHKIEDLMDQTLSTLGVI 56  
XP_028911360  1185 EERIRVTTERVAEMCFQMKEVHERVFYIKDSLVSLDSHLGHLQDLSALTVDTLKVI 1240
XP_029697935  1162 dERIKVTSERVENMFMRLEEVNERENTMKASLQTVDLRLAQLEEIHGRMAVALEKL 1217 torafugu
XP_017177501   520 DERIRVTSERVENMSMRLEEINERENFMKTSLQTVDLRLSQLEELSGRMVSALENL 575  house mouse
XP_046761457  1222 SERIRVTTERVEEMFLQLKEVYEKVFYIKESLLSLDSQLGHLQDMSALTVDILKVL 1277 chicken
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