Conserved Protein Domain Family
HIP1_clath_bdg
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pfam16515: HIP1_clath_bdg (This model is not part of the current CDD release)
Clathrin-binding domain of Huntingtin-interacting protein 1
HIP1_clath_bdg is the coiled-coil region of Huntington-interacting proteins 1. It carries a highly conserved HADLLRKN sequence motif at its N-terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. this binding then stimulates clathrin lattice assembly. Huntingtin-interacting protein 1 (HIP1) is an obligate binding partner for Huntungtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Hungtinton's disease. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding.
Links
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Statistics
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PSSM-Id: 522370
Aligned: 22 rows
Threshold Bit Score: 66.9755
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_031823829   450 HADLLRKNAEVAKQVTVMRQAQADLQREKKELEDTFHRANEQAQRKTQEQTEVLETLKQELAISKHEFQVLQGTLETSAQ 529 
XP_015221895   467 HAELLRKSADTVKMLSATQQTQEEVARTKQQLTFEMERIKQEAEMKLEEQKFDMEKLKRELGERKTELLRVQNTLLSNEK 546 
XP_007239764   467 HAELLRKSADTVKMLSATQQTQEEVERTKQQLAFEVERAKQESDMKLEEQKFEMDKLRRDLEEKILEIQRMKGTLQTCEK 546 
XP_003451671   468 HAELLRKSADTVKMLSVTQQTQEEVERTKQQLTFEMDRVKQEADMKMEEQRFEVERVKRELEEKMAEVTRIKATLQSSEK 547 
4_pfamImport     1 HAELLRRSADTVRMLSATQQTQEEVERTKLQLAFEVDRIKQEADMKLDEKKFEMEKLKRELEEKMAEVMRIRGTLKDSEQ 80  
13_pfamImport    1 HADLMRKNTDTVKQLTSTQHVQEELVRAKQQMAEELEKLKQENSMMLEAQKAEIVRLKQELLSGKAEITQVQSALQTKEK 80  
XP_005459699   453 HADLMKKNTETVKILSSTKQEHDDLQRAKYQLETELESLRREKTNVMNQQQMEVDRLNQELLEQRAELATLRSTLESKEK 532 
XP_003222791   459 HAELLRKNADTAKQLTVTQQSQEQVARVKEQLAFQMEQAKRESEMKLEDQILQMEQLKREMESKKDELAQLQESLGRSKQ 538 
XP_063127773   284 HAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQMEQVKRESEMKMEEQSDQLEKLKRELVAKAGELAHAQEALSRTEQ 363  Norway rat
NP_001025828   459 HAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKREAELKLEDQSMQMEQLRQELEARRDELDQAQRSLGHAKQ 538  chicken

XP_031823829   530 SEAKWTLQVEGLERERASL 548 
XP_015221895   547 AGEKLSGTLEGLQAEKEVL 565 
XP_007239764   547 ASDQINSSMTSLQVEKERL 565 
XP_003451671   548 TSEHMNSSMTALQAEKERL 566 
4_pfamImport    81 TSEQMNSSVTALQAEKERL 99  
13_pfamImport   81 SGDQLSSLLVGLQTEKEML 99  
XP_005459699   533 EGSQVSSSLTALQAEREVL 551 
XP_003222791   539 LGSDLNSQLDALQSEKDTL 557 
XP_063127773   364 SGSELSSRLDTLNAEKEAL 382  Norway rat
NP_001025828   539 AGTELSAQLETLQAEKEQL 557  chicken
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