Conserved Protein Domain Family
RhoGAP-FF1
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pfam16512: RhoGAP-FF1 (This model is not part of the current CDD release)
p190-A and -B Rho GAPs FF domain
RhoGAP-FF1 is the FF domain of the Rho GTPase activating proteins (GAPs). These are the key proteins that make the switch between the active guanosine-triphosphate-bound form of Rho guanosine triphosphatases (GTPases) and the inactive guanosine-diphosphate-bound form. Rho guanosine triphosphatases (GTPases) are a family of proteins with key roles in the regulation of actin cytoskeleton dynamics. The RhoGAP-FF1 region contains the FF domain that has been implicated in binding to the transcription factor TFII-I; and phosphorylation of Tyr308 within the first FF domain inhibits this interaction. The RhoGAPFF1 domain constitutes the first solved structure of an FF domain that lacks the first of the two highly conserved Phe residues, but the substitution of Phe by Tyr does not affect the domain fold.
Links
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Statistics
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PSSM-Id: 522369
Aligned: 21 rows
Threshold Bit Score: 104.63
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_009018707  269 DAHRVVMETKEITENAFMSLIKSHVgTDYKALWIPIHQQLQSNADFLSYIQLFGTDQAGRVFRKYLITVKEEYIKMKQKK 348 
XP_048580830  261 DAHKAQQEIVDRALHDYQALINRTV-TDFRCLWKNLKKVLELEKEFTVYKELNGSDACKRVFSKHIRKLRREFELRKLDL 339 
XP_004917008  261 EALKQQSQLIAAAKDKYEWLVSRVV-KSHNETWINQSRRMQSNIEYQDYVHLEGTDKAKKLFHQHVLRLKQEHIERRRRN 339 
XP_028921023  261 EALKQQSQQIAAAKDRYEWLVSRLV-KSHQDSWPGASRQLQAAPEFQDYVYLEGTPKAKKLFAQHTLRLRHEHVERRRRL 339 
XP_004917331  260 EAFKIHRQIVISASDKFDKLIVQTV-RDYHAVWKTVSNKLKNHSDYEDYINLEGTVKAKKTFSKHIDQLKQEHIRKRKEE 338 
XP_001336016  258 EAYKSQRQLVASVSDKFEKLIVQTV-RDYHTSWKIVSNKLKSHPDYEEYINLEGTKKARNTFSKHIEQLRQEHIKRRRED 336 
XP_023807832  259 EAFKVQRQLVASATDKFEKMILNTV-RDYHTTWKTVTNILKGQTDYEEFITLEGSRKAHNMFTKHIAQLRQEHIRKRREE 337 
XP_014350269  268 DAYKTQRQLVATAADKFEKLIGQTV-RDFHATWKTVSNKLKNHPDYEEYINLEGTKKAKNIFSKHIEQLKQEHIRKRRDE 346 
XP_046761035  261 EALKQQSQQIAAAKDKYEWLVSRVV-KSHNETWAAVSRKMQPAPEYQDYVYLEGTPKAKKLFLQHVQRLKQEHIERRRRT 339  chicken
XP_021332229  261 EALKHQSQLIASAKDRYEWLVNHIV-KNHNETWPNVSRRMQTSPEYKEYVFLEGTGKAKKLFQQHIHRLKQEHTERRRKA 339  zebrafish

XP_009018707  349 Y 349 
XP_048580830  340 Y 340 
XP_004917008  340 Y 340 
XP_028921023  340 Y 340 
XP_004917331  339 Y 339 
XP_001336016  337 Y 337 
XP_023807832  338 Y 338 
XP_014350269  347 Y 347 
XP_046761035  340 Y 340  chicken
XP_021332229  340 Y 340  zebrafish
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