pfam16493: Meis_PKNOX_N (This model is not part of the current CDD release)
TALE/MEIS homeobox family N-terminal domain
This entry represents an alpha-helical domain found at the N-terminus of members of the TALE/MEIS homeobox family. The TALE/MEIS homeobox family is involved in transcriptional regulation, often through the formation of complexes with HOX or PBX proteins. Members of the family play crucial roles in developmental processes, including patterning of the embryonic cuticle, eye field delimitation, and central nervous system formation. They are also implicated in cell fate determination, hematopoiesis, megakaryocyte lineage development, vascular patterning, and myeloid differentiation. Some family members are known to bind specific DNA motifs, thereby activating transcription of genes such as ELA1, EPHA8, and DRD1. The family's functions extend to the regulation of gene expression in response to signaling pathways, such as Wnt, FGF/MAPK, and retinoid signaling, and they are involved in lipid homeostasis and innate immunity.
Jiyao W et al.(2023). "The conserved domain database in 2023.",