4KXT,5W6V,7SWQ


Conserved Protein Domain Family
ArgoN
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pfam16486: ArgoN (This model is not part of the current CDD release)
N-terminal domain of argonaute
ArgoN is the N-terminal domain of argonaute proteins in eukaryotes. ArgoN is composed of an antiparallel four-stranded beta sheet core that has two alpha helices positioned along one face of the sheet and an extended beta strand towards its N-terminus. The core fold of the N domain most closely resembles the catalytic domain of replication-initiator protein Rep. The N domain is linked to the PAZ domain via linker 1 region, and together these three regions are designated the PAZ-containing lobe of argonaute.
Links
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Statistics
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PSSM-Id: 522350
Aligned: 254 rows
Threshold Bit Score: 31.7759
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4KXT_A         39 KPIKLLANYFEVDipkidvyhyevdikpdkcprrvn--------revveymvqhfkpqifgdrkpvyDGKKNIYTVTALP 110 human
7_pfamImport    1 ETIQLVTNHFKVSmhsnantgahfyqynvslahedghpadakdigrkvmdkvhetyhtemagmsfayDGEKSLFTIGSLP 80 
NP_001266010   28 QKIRLLTNHFKVGmnntdghffhysvainyedgnpvevk---gvgrkildkvhqtysmelagkdfayDGEKSLFTIGALP 104
XP_020877222   54 QKIPLLTNHFGVKfnkasgyffhysvaisyedgrpveak---gigrkildkvqetyqsdlgskyfayDGEKTLFTVGALP 130
25_pfamImport   1 QKIDLLTNHFGVNfttsksqhffqysvaityedgnpvea--kgigrkilakvqetyqtdlgskhfayDGDKILFTVGPLP 78 
EFH50287       25 KKIHLLTNHFRVNfsqpnnhdffhysvaityedgspvea--kgigrkilekvqqtyqtdlgfkhfayDGDKNLFTAGPLP 102
Q3E984         35 QKILLLTNHFRVNfrkpnshnffhysvtityedgsplla--kgfgrkilekvqqtcqadlgckhfayDGDKNLYTVGPLP 112 thale cress
26_pfamImport   1 VRTPLLTNHFRVNfnnanghfyhysvtityedgspmeai---gvfrkilekvqetyrtdlgskyfayDGHKNLFTIGALP 77 
29_pfamImport   1 QRIPLLTNHFKVNfnnangqffhysvaityedgrpveak---gigrkildkvqqtyktdlgskyfayDGEKTLFTVGPLP 77 
XP_033138521   45 VKTHLLTNHFRVNfnnsnghffhysvaityedgrpveak---gigrkilekvqetyrtdlgskyfayDGEKTLFTVGALP 121

4KXT_A        111 IGNER--------VDFEVTIp-------Ge-------gKDR--IFKVSIKWL--AivsWRMLHEALVSGQIPVPLESVQA 164 human
7_pfamImport   81 SKKLRftvvledaSSNRYKCtlnidspdDgsdrkrsrrPYHskTFNVEISFAa-Kf-pMDSIVRASYGQPSKHLQDAARV 158
NP_001266010  105 GNKLEfdvv-ledVSSSRTDrgspdgspSdvdrkrskkQPWskAYKVVIKYAa-Ki-pMQAIANALRGQDSEQYQEAVRV 181
XP_020877222  131 SNKLDfsv--vleDIPSSRNnag--ndtNdgdrkrsrrPNQskKFMVEISYAa-Ki-pMQAIASALQGKETENLQDALRV 204
25_pfamImport  79 NNKLDfsv---vlEDMSCTRsnt---stSdantkrlrpHNQskRFNVAISFAa-Ki-sMQAIQGALQGKETNDLQDAVRV 150
EFH50287      103 GSNLEfs-----vVLEDMSSrr----naGkrl----rlSHQskKFNVAISFAa-Ki-pMKAIANALQGKETNHFQDAIRV 167
Q3E984        113 RSSLDfs-----vVLETAPSrr----naDkrl----klPHQskKFNVAILFAppEi-pMEAIANALQGKKTKHLLDAIRV 178 thale cress
26_pfamImport  78 SNKMDflv--vleNTPSSRNntgn-aspNdadrkrsrlPHRskKFMVEISYAa-Ri-pMQAIASAIRGKETDNIQDATRV 152
29_pfamImport  78 SNKLDfsvvledaPSSRNNTgngspnesNdadrkrskrPNQskKFMVEISYAa-Ki-pMHAIAAALQGKETDSLQDAIRV 155
XP_033138521  122 SNKLDfsvvledtSSSRNNTgnaspnesNdadrkrsrrPNRskKFMVEISYAa-Ri-pMQAIASALQGKETDYLQDAIRV 199

4KXT_A        165 LDVAM 169 human
7_pfamImport  159 LDIIL 163
NP_001266010  182 LDIIL 186
XP_020877222  205 LDIIL 209
25_pfamImport 151 LDVIL 155
EFH50287      168 MDVIL 172
Q3E984        179 MDCIL 183 thale cress
26_pfamImport 153 LDVIL 157
29_pfamImport 156 LDVIL 160
XP_033138521  200 LDVIL 204
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