4DKK


Conserved Protein Domain Family
Staufen_C
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pfam16482: Staufen_C (This model is not part of the current CDD release)
Staufen C-terminal domain
This is the C-terminal domain of Staufen proteins. It consists of an N-terminal Staufen-swapping motif (SSM) comprising two alpha helices, connected by a linker region to a dsRNA-binding-like domain ('RBD'). The 'RBD' has the fold of a functional dsRNA-binding domain, but lacks the residues required to bind RNA. This domain is responsible for dimerization, the SSM from one molecule interacts with the 'RBD' of another.
Links
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Statistics
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PSSM-Id: 522347
Aligned: 6 rows
Threshold Bit Score: 165.084
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4DKK_A         5 SKATVTAMIA--RELLYGGTSPTAETiLKNNISSGHVPHG-PlTRPSEQLDYLSRVQGFQVEYKDfpKNNKNEFVSLINC 81  human
XP_014349083 537 SNTSNTATIA--RELLLNGTSPTAEA-IGLKGKTPVSPCS-A-VQPFQQLEYLARIQGFQVQYSD--RQNGKECMTYLTL 609
NP_957219    526 PSVGNTATIA--KELLLSGTSPTAEA-LVLKGKAPALACG-S-IQPSQQLEYLAHIQGFQVQYSD--RQTDKEFMTYLTL 598
EEC05302     527 GDLQASSAIA--KELLDQGVSPTAEAlRQAAPLTVA-----P-VRPKQQLLYLAEVLGFQVHFTDfpKGNKRDFLSLVTL 598
1_pfamImport   2 TKATVTAMIAmiAGKLYGGTLPTAKTiLKNNISLGHVPQGpL-THP---LSNCPRVQGFQVEYKDfpQ-NKNKFVSCINC 76 
O95793       447 AKATVTAMIA--RELLYGGTSPTAETiLKNNISSGHVPHGpL-TRPSEQLDYLSRVQGFQVEYKDfpKNNKNEFVSLINC 523 human

4DKK_A        82 SsqPPLIS-HGIGKDVESCHDMAALNILKLLSELD 115 human
XP_014349083 610 S--PVQMTfHGIGSSIEASHDQAALSALKQLSEQG 642
NP_957219    599 S--PVQMTfHGIGSSIPASHDQAALSALKQLSEQG 631
EEC05302     599 TtcPPQVS-HGAGSSLEASHDEAALAVLRTLARRG 632
1_pfamImport  77 SsqPSLIL-HGIGNNVESFHNMAALNILKLLPELD 110
O95793       524 SsqPPLIS-HGIGKDVESCHDMAALNILKLLSELD 557 human
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