4YKN,2Y3A


Conserved Protein Domain Family
PI3K_P85_iSH2

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pfam16454: PI3K_P85_iSH2 (This model is not part of the current CDD release)
Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
This domain is found between the two SH2 domains in phosphatidylinositol 3-kinase regulatory subunit P85. It forms a complex with the adaptor-binding domain of phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha.
Statistics
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PSSM-Id: 522335
Aligned: 22 rows
Threshold Bit Score: 112.777
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4YKN_A        121 YQQDQVV--KEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKR-TAIEAFNETIKIFEEQCQTQERYSKE 197  human
XP_032515255  117 HQENDGG--ENISDETLETRYKNIHKEFVLKTRDYDERSDKYMRLREEVKFKR-QALDAFKETVKVCEDHLKLQEKMQSE 193 
ADM32530      117 HQENEGG--ENISDETLATRYKEIHKKYILKTRDYNIRFSKYTRLREEVTLKR-QALEAFREAVKMCEDHIKLQEKIQAE 193 
XP_002074280  130 YEEDEYQ--PQGDLRLLSNDFRRVSQLLQQQEQMLDQKKTSFNAIREELQEKK-LHQNVFGNAEKMFRDQIKVIESFIRQ 206 
EFN87788      397 QQDDEIA--NTTDMTKVVQKFVELEKDITDTIRQYQNCSDLYGKTAYEVQLKR-QALEAFSEAIKMFEEQMKLQEKFQKE 473 
EFN63874      887 QQEDEIT--NTTDMAKVLQKFLDLEKEVSDGIRQYHNCWDLYTKTSSEVELKT-QAMEAFQEAIKMFEEQIRLQDEFRKE 963 
XP_002431096  421 QQEDEIA--SSLNIEKVAKKLAEIEAQLQDKSRTFQKLKEDFNKISKEIEVKRgPTMDAFIELTNMFKEQQELQERFKKE 498 
2_pfamImport    1 QQDEEFGtwKSLNVDVVWMRLIEVLKDILKKSISYEELSKEFQSITADILVMR-MGLQQYQEVNRMFEDQLRVHDKFLKK 79  
XP_015785711  109 SEVCEES--ESEDINALSEKLIKINKQCLIIANSYDKYHDQYNKILHDIGMYK-QAFESINETIAILEAHIKLNETLKKE 185 
XP_002051878  128 VCPFYDEaqPQGDLRVLSEQFIRCSQLLLQQEQALDQKKTAFNAIREELAERK-LQQRVFGNAENMFFRQIALIESYMIK 206 
4YKN_A        198 Yiekf-----------------------kregN-----EKEIQ-RIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYRE 248  human
XP_032515255  194 A-------------------------------Q-----PHEKN-DLIENNRQLISKVNSFKQARAQLHNILRETVESNLL 236 
ADM32530      194 A-------------------------------Q-----PHEKN-IVLENNRQLMAKLQSLKQAKAELSEILRTTLECNLV 236 
XP_002074280  207 PpvntagagggpavgsgagaasaaslssscttNnaatrQQEQE-HLQESLAQANAHLDELHSKMEKLNHYIENKKEDELL 285 
EFN87788      474 A-------------------------------Q-----PHEIS-TLTDNAELLKRRLKSLEDSKEQLDESLKQQIAYYRT 516 
EFN63874      964 A-------------------------------Q-----PHEIS-TLTDNSELLQRRLKALRDSKIQLQENLNQQTAYNRT 1006
XP_002431096  499 A-------------------------------Q-----PHEIK-SLMVNSELLKQRIKSLEESRELLKENLKQQVAYYKT 541 
2_pfamImport   80 A-------------------------------E-----RHEAD-NLVKNIEIVKKRIKLLLEGKAALEEKLFFQVDYSQT 122 
XP_015785711  186 A-------------------------------L-----SHEIK-AMEDHCRILTKRRDEMVCKRGDIECKLKTATNLSRS 228 
XP_002051878  207 Ppvnasggsggss--------paaatggsgacS-----RQDVQqHMHENLLHMKEHLKVMHAKMERLNQDIKARKEEEQL 273 
4YKN_A        249 IDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG 289  human
XP_032515255  237 LEREITKLKSEIINLYKIKDRYKKLLQRRGKTEEYLQALEE 277 
ADM32530      237 VERDLTKLKSDVVKLYNLKDRHKMWLQGRGKSDEYLKALEE 277 
XP_002074280  286 LERQINAAKPELQMLQLRKDKFIERLKTHNLTVDDMNAILE 326 
EFN87788      517 LEREMYKLKAEIGQLVRQKDRHFMWLKKNGMKQNKINQLVL 557 
EFN63874     1007 LERETCRLKSETGQLARQRDRYALWLKKNGIKQNK---DFA 1044
XP_002431096  542 LEREMLTVKREMLGLSKQKEQHMKWLLCKGVKQSQIDHFLA 582 
2_pfamImport  123 LERQMYKLKSEGAILTRQKDKSVRWLLTHGVAYEAIHRVLN 163 
XP_015785711  229 LDREMNGLKPQVTQLHRQRDILQTMLTNKSVSKEVIENILQ 269 
XP_002051878  274 LERQINASKPELQELQLRKDKHIERLKGFGLTEDDLNVLLE 314 
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