6UOX


Conserved Protein Domain Family
NPC1_N

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pfam16414: NPC1_N (This model is not part of the current CDD release)
Niemann-Pick C1 N terminus
This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Statistics
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PSSM-Id: 522318
Aligned: 128 rows
Threshold Bit Score: 200.522
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6UOX_A          25 CVWYGECG----IA-YGDKR-------YNCEYSGPPKPLPK--DGYDLVQELCPGFFF---GNVSLCCDVRQLQTLKDNL 87   human
XP_028930439    32 CSFYEECG----RNpEISSSlip--piVPCLNNSPARALEG--EHLQLLQEVCPRLDQg-pGATFACCSLKQLRSLKRSI 102 
13_pfamImport    4 CALYEECGknpeL---PGSLael--snVPCLSNTPARHVAG--QHLILLRRICPRLYNg-lNTTYACCSSKQLESLELSL 75  
XP_023494783    33 CAFYDECG----KNpELSGGlgt-lsnVSCLSNTPARQVTG--DHLTLLQHICPRLYTg-pSSTYACCSLQQLVSLEASL 104 
11_pfamImport    4 CAFYDECGknpeL---SGSLagl--adVSCLNNTRAPRLTG--DHLALLQRICPRLYAg-pDATFACCSRKQLLSLEKSL 75  
24_pfamImport    4 CAFYDECGknpeL---SGGLtsl--snVSCLSNTPAVHVTG--NHLTLLRRICPSLYAg-pNTTYACCSSKQLVSLEASM 75  
XP_003504803    32 CTFYEECGknpeL---SGGLtsl--snVSCLSNTPARHVTG--DHLTLLQSICPRLYNg-tNTTYACCSAKQLVALEKSM 103 
XP_003757816    33 CAFYDDCG----KNpELSGGllp-lpnVSCLSNTPARKLTG--DHLQLLKSICPRLYEg-pDSTFACCSPKQLIALQNSL 104 
XP_001379744    45 CAFYDDCGknpeL---SGSLipl--anVSCLSNTPAFKLSG--DHLELLNKICPELYQg-pDSTYACCSIQQLLDLQGSL 116 
XP_026690141    29 CMLYGNCGy------YEENDpthskgeLPCLDNRKAVVLDKtsAHYKSLAKTCPNLIKpdgEPTAICCDPQQLNTLERQL 102  vase tunicate
6UOX_A          88 QLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEdyvdpVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPS 167  human
XP_028930439   103 ALSKVILTRCPACAENFASLHCQNTCSPNQSLFINVTRVH--------TDSSAVLAYQSFYTRRYAEEAYSSCSEVRIPA 174 
13_pfamImport   76 AITKALLTRCPACSDNFVSLHCQNTCSPNQSLFINVTRVFqlat----gqpaAVLAYQAFYQRSFAEHAYDSCSLVRIPA 151 
XP_023494783   105 AVTKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAg----QGGSQPRAVVAYEASYQRSFAEQTYDSCSRVRVPA 180 
11_pfamImport   76 AITKALLTRCPACADNFVSLHCHNTCSPDQSAFINVTRVVvrga----gkppAVVAYEAFYRRSFAERTYDSCSRVRIPA 151 
24_pfamImport   76 SITKALLTRCPACADNFVTLHCHNTCSPDQSLFINVTRVArggp----aqlpAVVAYQAFYRRSFAEQTYDSCSRVRIPA 151 
XP_003504803   104 SITKALLTRCPACSDNFVSLHCHNTCSPDQSLFINVTRVVvqkdp---qqppAVVAYEAFYQRSFAEKAYESCSRVRIPA 180 
XP_003757816   105 KVPKVLLSRCPACVENFASLHCQNTCSSNQSLFINVTRIVp----IEGTNLSKVVAYQAFYKQSFAERTYNSCSKVQVPA 180 
XP_001379744   117 SISKTLLTRCPACAENFAAFYCHNTCSPNQSVFINVTRIAnisg----tnssKVLAYETFYTRDFAERAYNSCNKVQIPA 192 
XP_026690141   103 TASVLVFNRCPSCVENFRGLYCQITCSPNQATFMNVTEMrnt-teTEGAFTESI-----YISETYATNVHTSCKDVIFPQ 176  vase tunicate
6UOX_A         168 SNDKALGLLCGKdadA----CNATNWIEYMFNKDNgQAPFTIT-P-----VFSDFP-------------VHGMEPMNNAT 224  human
XP_028930439   175 TGGLAVGAMCGV---YgaelCNAQRWLDFQGNPSNgLAPLQVDfHl---lDPGQAP-------------GAGLQPLDTDL 235 
13_pfamImport  152 AASLAVGTMCGV---YgsalCNAQRWLNFQGDTSNgLAPLEITfHlldpsQA---P-------------GNGIQLLNSEI 212 
XP_023494783   181 AATLAVSTMCGV---YgsalCNAQRWLNFQGDTGNgLAPLDITfHl---wEPGQTP-------------GSGMQPLNGET 241 
11_pfamImport  152 AATLAVGAMCGV---YgsalCNAQRWLNYQGDTSNgLAPLDITfHlwepdQA---A-------------GSPMQPLDAEL 212 
24_pfamImport  152 AATLAVGTMCGV---YgsalCNAQRWLNFQGDTGNgLAPLEIVfHlidpgQD---M-------------GSGLQPLDATI 212 
XP_003504803   181 AASLAVGTMCGV---YgsalCNAQRWLNFQGDTGNgLAPLDITfHlmesgQA---P-------------ADGMQPLNGEI 241 
XP_003757816   181 TGSLAIGTMCGV---YgsdlCNAQRWLNFQGDTGNgVAPLEIAfHl---lQPGQLP-------------GSGIEALDAEM 241 
XP_001379744   193 TGGLAVGAMCGV---YgaklCNAQRWLNFQGDTGNgLAPLEVTfNlvdpgQV---L-------------GNGLEPLDVET 253 
XP_026690141   177 TNGKAMALVCNG---FsgddCTPQRFLDYLGSTNNgIAPLNMDfQq--------iGndtgpnsdaiqspPEGMAPLDAFA 245  vase tunicate
6UOX_A         225 KGCDeSVDEvTAPCSCQDCSIVCgp-kPQPPPPPaPWTILGLDA 267  human
XP_028930439   236 WQCHlSYGDtMEACSCQDCATACpvlpSLDPENS-GFRLGILLI 278 
13_pfamImport  213 VSCNeSQGIgSPACSCQDCATSCpdiaHPQALDA-TFRFGQMAG 255 
XP_023494783   242 AHCNeSQGDgTAACSCQDCAASCpviaQPQALDT-TFRLGRMAG 284 
11_pfamImport  213 TPCNqSQGg-AAACSCQDCAASCpaiaRPEALDA-TFRLGRL-G 253 
24_pfamImport  213 MPCNeSQGDsASACSCQDCAASCpvisRPQPLDT-TFYLGWMPG 255 
XP_003504803   242 TPCNqSQGEdLAACSCQDCAASCpvipQPPALRP-SFYMGKMPG 284 
XP_003757816   242 WNCNeTRGNdSNACSCQDCALACpaiaHPPMQDS-TFRLGRMHS 284 
XP_001379744   254 WGCNeTRGNgSNACSCQDCASSCpviaQPAMQDS-TFRLGRMHG 296 
XP_026690141   246 YKCQdAPSPtEFACSCTDCEASCpappILQPDQV-PFMIGTADG 288  vase tunicate
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