4FMN


Conserved Protein Domain Family
Mlh1_C

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pfam16413: Mlh1_C (This model is not part of the current CDD release)
DNA mismatch repair protein Mlh1 C-terminus
This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site.
Statistics
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PSSM-Id: 522317
Aligned: 153 rows
Threshold Bit Score: 136.142
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FMN_A         29 NLTSIKKLREKVDDSIH-RELTDIFANLNYVGVVDEerRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDF-----ANFGK 102  Saccharomyces...
5_pfamImport    1 EFESLEFLRRQIVNESS-LSLRNLFKTCIFVGSIDP--QTILVQFGTSLYQIDFAAVLREFFYQISIFSF-----GNYGS 72  
Q9XU10        501 HFESIEVLRKEIIANSS-QSLREMFKTSTFVGSINV--KQVLIQFGTSLYHLDFSTVLREFFYQISVFSF-----GNYGS 572  Caenorhabditi...
EGT60154      500 DFESLDIIRRQIVSTTS-LSLREMIKTSTFVGSIDC--EQVLFQFGTSLYIMNFKAVLREFFYQISIFSF-----GNFGS 571 
XP_045095682  500 EFESLEILRHQIASSAS-LSLRELIKTSTFVGSIDP--ETVLIQFGTSLYMLKFSEILREFFYQISILSF-----GNYGS 571 
Q57TS9        623 LLTSVSTIVSNIRAGTS-QTAQSLFQNLAYVGVLKG--HLFFAQSGTTLYVVDSLRLVRHVVYQRIFLRWatpslSAVPQ 699  Trypanosoma b...
Q8IIJ0        710 EISSIKKLKMICEEKEK-KELTECLKNSIYVGPVDN--MHSLIQYKEKLLLIKMPLIIKEVTYQSILNRL-----GKIPP 781  Plasmodium fa...
Q5CRJ3        548 TEIEIMNDNTEASKMEYlKSLTKNIINGIYIGQIKS--SWSIIQAKNQILLINIEQMSKIALKQSLICRL-----GYIPL 620  Cryptosporidi...
XP_002139205  543 TQRIIKNYWNNISEGIE-DDLARSLSNSIYIGLVKH--PICLVQAENELLLVNTKKMANLAIIQSIIDRL-----GRLPT 614 
XP_002259179  560 dISSIRKLKRICEEKEK-KELTECLKNSIYVGAVDN--LHSLIQYKDKLLMIKMPLIIKEITYQSILNRI-----GRIPP 631  Plasmodium kn...
4FMN_A        103 INLqstnvSDDIVLYNLLsefdeln--------------------ddaskekIISKIWDMSSMLNEY---YSIEL----- 154  Saccharomyces...
5_pfamImport   73 YRLe----EDPPAIQELLellgelsasdenya-------afevfagaekrkeAEAMLAEHAELLNDY---FAIKLewsde 138 
Q9XU10        573 YRLd----EEPPAIIEILellgelstrepnya-------afevfanvenrfaAEKLLAEHADLLHDY---FAIKLdq--- 635  Caenorhabditi...
EGT60154      572 YRLe----QEPPSILEMLeligelsenderyk-------gfgvfkqeekrveAENLLGEQAELLHDY---FAIKMewfge 637 
XP_045095682  572 YRLe----EETPLIIDMLeligelsetdenyk-------afsifrdpttreeAEFLLGEHVELLYDY---FAIKMewmcl 637 
Q57TS9        700 LSF-----EEPIHLSDLLsfalqndvqlppsq-------kradggpgsllsrLGRRLCNWRYMLQDY---FAVEI----- 759  Trypanosoma b...
Q8IIJ0        782 FEF-----DPPIPLYDLLlvavnnsysgfyen------pnyankniekvcneLEQIFYTYNEMYSDY---FSIII----- 842  Plasmodium fa...
Q5CRJ3        621 LKL-----NPPVSLGELSlfgtesvkny---------------klnendqiqLKDFINSQAYLYFDIlkvLGIDF----- 675  Cryptosporidi...
XP_002139205  615 LRF-----NPPIDLREIFslmenhynsksqfkyndnlfskytnsnlrinlekSVILLNHYSSYISSI---FGIYI----- 681 
XP_002259179  632 FKF-----DPPIPLYDLLlvamnnsqsgyfen------pdyvtkniericneLEQVFYSYEEMYADY---FSIII----- 692  Plasmodium kn...
4FMN_A        155 --V-NDGldnDLKSVklkslPLLLKG-YIPSLVKLPFFIYRLGKEVDWE--DEQECLDGILREIA-LLYIpdmvpkvdt- 226  Saccharomyces...
5_pfamImport  139 nlGeKKL---ILTGI-----PSLVHY-YVPQLEKLPFLIAELVLEVDYD--DEKSCFESICRALG-RLFSlhtgf----- 201 
Q9XU10        636 -lEnGRL---HITEI-----PSLVHY-FVPQLEKLPFLIATLVLNVDYD--DEQNTFRTICRAIG-DLFTldtnf----- 697  Caenorhabditi...
EGT60154      638 eeDqRRL---HLTEI-----PSLVHY-YVPQLEKLPFLIAALILDVDYD--DEQKCFESVSRAIG-DLFTlhkhf----- 700 
XP_045095682  638 egEkRRL---HITEI-----PSLVHH-YVPQLEKLPFLVASLILDVEYD--DEQKCFQSICRAIA-ELFTlhspf----- 700 
Q57TS9        760 --S-ADG---HLIAL-----PLSMGTsWPPPLRAVPLFIWRLAAEVPYNa-GEIECFTAIARHIAeTLYGvqlhss---- 823  Trypanosoma b...
Q8IIJ0        843 ----EDG---CIVTF-----PACCGE-YFPGQEFLPFLFLRLATQIDYS--KEINCINGICYLLA-NFYSkitllndkew 906  Plasmodium fa...
Q5CRJ3        676 --DsSNN---SFSTL-----PLFFGN-FVPNIDFLPELFEHVIFA-CWNfhIAHACKQKLLNTGSaQILNphfneen--- 740  Cryptosporidi...
XP_002139205  682 --NvKNM---QLETF-----PLCFGD-YLPNIDMLPNTLYQIISL-----------LDTFYDSIS-NLYQnilenn---- 734 
XP_002259179  693 ----EDG---CVCTF-----PACCGE-YFPGQEFLPLLFLRLATQVDYE--NELNCINGICYLIA-NFYSkvtllddkew 756  Plasmodium kn...
4FMN_A        227 --------------------------------------------sdaslsedEKAQFINRKEHISSLLE----------- 251  Saccharomyces...
5_pfamImport  202 -----------------------------------------------vtadkLVSKFST--MRWKPMVK----------- 221 
Q9XU10        698 -----------------------------------------------itldkKISAFSA--TPWKTLIK----------- 717  Caenorhabditi...
EGT60154      701 -----------------------------------------------vtdekKVSRFST--MYWKPLIK----------- 720 
XP_045095682  701 -----------------------------------------------itaekKVSAFCG--THWKPLIK----------- 720 
Q57TS9        824 ----------------------------------------------wlpnviKDGIRQDDVPPFCDAIR----------- 846  Trypanosoma b...
Q8IIJ0        907 tyqddllmiqekekeiqmllnksnkhinnsnhhnqhydetnldyilgdesvvDINKHLSVSRNINLVFE----------- 975  Plasmodium fa...
Q5CRJ3        741 ---------------------------------------------nclsdkiSEDYIIKLYELFIELIEilvdyyl-fgi 774  Cryptosporidi...
XP_002139205  735 -----------------------------------------------lkpeiLESNLDNFANSLLEIVKvislcyisgpe 767 
XP_002259179  757 tfqnellmlkekeiqmlqgqa-ttdgsgeasplanddqtyhfenilgdetviDVNRHLAASKNINLVFE----------- 824  Plasmodium kn...
4FMN_A        252 ---HVLFPCI---KRRFLAPRHILKdv--vEIANLPDLYKVFERC 288  Saccharomyces cerevisiae S288C
5_pfamImport  222 ---HILFPLV---KRKLIPPESFKQqnvikQLADAHDLYKVFERC 260 
Q9XU10        718 ---EVLMPLV---KRKFIPPEHFKQagvirQLADSHDLYKVFERC 756  Caenorhabditis elegans
EGT60154      721 ---QILMPLV---KRKFIPPEHFKEkqiikQLADSHDLYKVFERC 759 
XP_045095682  721 ---QVLMPLV---KRKFIPPEHFKSadifvQLADSHDLYKVFERC 759 
Q57TS9        847 ---FGLLPCAt-nSTFFVPPCDALVdgtvqAVVSVDELYKVFERC 887  Trypanosoma brucei
Q8IIJ0        976 ---KYFFPMIq-lNNIMKIPTTFSNngyiiELTSLNQLYKIFERC 1016 Plasmodium falciparum 3D7
Q5CRJ3        775 ednELLFQAIrnnNNLILVEDQISQni--iELSSLEKLYRVFERC 817  Cryptosporidium parvum
XP_002139205  768 cnsEHLFQAIkrnNCLVIPSSSLDStt-viHVTSLEKLYRVFERC 811 
XP_002259179  825 ---KYFFPMIq-lNTIMRVPRTFSTngyiiELTSLNQLYKIFERC 865  Plasmodium knowlesi strain H
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