Conserved Protein Domain Family
GtaA_6_Hairpin

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pfam16335: GtaA_6_Hairpin 
Glutaminase A six helical-hairpin domain
This entry represents the six helical-hairpin domain found in homologues of Glutaminase A from Aspergillus oryzae. Glutaminase catalyzes the hydrolyzis of glutamine to glutamic acid and plays a key role in nitrogen metabolism. It catalyzes the hydrolyzis not only of L-glutamine but also of D-glutamine. This domain share similarity with six-hairpin glycosidases.
Statistics
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PSSM-Id: 495762
Aligned: 79 rows
Threshold Bit Score: 363.022
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jcvi:TREAZ_2972 328 GPDYQLITNLAYRQSIAAHKLIADEK-GEALFISKECFS-------NGCAATVDISYPSTPLYLLYNPELVKGMLRPILH 399 
WP_015266520    482 GRKYADMCILAYRQAIAAHTLVEGPE-GELLFLSKENNS-------NGSINTVDVTYPSAPLFLYYNPDLMKGMLNGIFY 553  Echinicola ...
WP_015333805    484 GKEYADLCQLAYRQAIAAHKIVAGPK-GDVFFLSKENFS-------NGSIGTVDVTYPSAPMFLLYNNELAKGLLRFIFD 555  Fibrella ae...
CDD00603        485 NVHYAELLSASYRHVMAAHKLFEDND-GNLLFFSKENAS-------NGCVNTVDLTYPSAPLFLIYNPDLLKAMMTSIFK 556 
CCZ14663        493 NKEYAEILSASYRHCIAAHKLFEGPN-GNLYFFSKENNS-------GGFVNTVDLTYPESPLFLLYNPELQKAMMRSIFE 564 
3_pfamImport      1 NAHYAEILSGSYRHVLAAHKLFEDNE-GHLLYFSKENNS-------NGCVNTVDLTYPSAPLFLAYNPELQKAMMTSIFE 72  
Q8A1W2          630 GKEYAELCALAYRQSVSAFQMSEDSD-GELLYFTPQ-------------VGPVDEYYPASPLYLRYNPDLVKAMLNPFFY 695  Bacteroides...
CCY38578        343 GKEYAELCALAYRQAIAAHKLVESPD-GELMFLSKENFS-------NGSIGTVDITYPSSPLFLLYNVELVKALLNPIFH 414 
XP_004343605    341 SDAYTTSLALAYRQTTGATKFTIDPAtKEVFLFMKEISS-------DGDVSTVDVIFPAAPFFLALNPTLVTKLMLPVLK 413 
XP_004365368    343 SNSYTTLLSLVYRQVTASTEHAIDTTtQQHYVFMKTFATsstngpvNGQVNAVTTMFFASPFYLLLNPSLVPKMLLPVLK 422 
jcvi:TREAZ_2972 400 FSGL-SVWIYD--FAPHDAGRYPYVTGQVYGLknldmkntevyphfyafpansdaydpRYQMPVEECGNMIIMMAAVAKA 476 
WP_015266520    554 YSES-GRWKKP--FPAHDLGTYPIANGQTYG----------------------------EDMPVEEAGNMLLLTAAIVHQ 602  Echinicola ...
WP_015333805    556 YSES-GRWKKD--FPAHDIGTYPLANGQTYG----------------------------EDMPVEEAGNMIILTAASVKM 604  Fibrella ae...
CDD00603        557 YSRS-GRWDKP--FAAHDLGTYPIANGQVYG----------------------------ADMPLEEAGNMLTLAAEISRI 605 
CCZ14663        565 YCRS-DRWGFP--FAAHDLGIYPHANGQRYSItrpna-----------------dggfEGNMPLEESGNMVTLCAMLSML 624 
3_pfamImport     73 YSRS-GRWTKP--FAAHDLGTYPIANGQVYG----------------------------GDMPIEEAGNMLTLAAQLCIQ 121 
Q8A1W2          696 YSES-GKWGKP--FPPHDLGGYPIVNGQTIG----------------------------GDMPVEEAGNGLIMTAAIAKM 744  Bacteroides...
CCY38578        415 YSES-GRWSKP--FPAHDIGTYPLANGQTYN----------------------------GDMPVEESGNMLILTSAVCSL 463 
XP_004343605    414 YGNNeTSIPYNlaWAPHHLGTWPVCNiap---------------------------gqQEQMPIEESGNLLLMIAAAAQR 466 
XP_004365368    423 YANSeTSFPYTrsWAPSHLGQWPLCTtav---------------------------ptTYDMPVEHTANMLIMITAAAQR 475 
jcvi:TREAZ_2972 477 EGNADFSKPYLALLEKWAVYLETYGTDPGEQLCTDDFAGHLAHNCNLAAKAIMGLEAFGLILDMVGDKAKAARYHDKAKT 556 
WP_015266520    603 ENDPAYAREHWEILTVWAEYLRKSGFDPANQLSTDDFAGHLARNANLSVKAILALAAYGKMAGMLGMKSVEGDYRAEARG 682  Echinicola ...
WP_015333805    605 DGNANFAREHWPTLTKWVGFLKRDGFDPGNQLCTDDFAGHLARNANLSAKAIVGIACYGQMAAQLGDQKTADEHLTLARD 684  Fibrella ae...
CDD00603        606 EGNTAYADRYWDIITTWADYLVEHGLDPANQLCTDDFAGHWAHNANLALKAIMGVAGYAKMAEIRGNADVAKRYMDKARE 685 
CCZ14663        625 DGNTSFADQYWDTIKLWTDYLVENGQDPENQLCTDDFAGHWAHNANLSMKAIMGIAGFSEMARMKGDIETADKYMAKAKE 704 
3_pfamImport    122 DGNIDYVKPYWDILTQWTDYLVENGQDPSNQLCTDDFAGHWPHNCNLSVKAIMGVAGYALMARMKGDAATAERYMNRARQ 201 
Q8A1W2          745 EKNASYAEKHWKTLTQWAEYLLENGTDTGDQLTTDNFAGNCPHHANLSAKGVLGIAAYARLAEMLNKKEEAEKYMNAAGE 824  Bacteroides...
CCY38578        464 EGKADYALQHWETLTKWVQYLEEKGLDPEEQLCTDDFAGHFAHNTNLSIKAILGIASYSRLARQLGEESLSDRYRKVALE 543 
XP_004343605    467 NVSLDYLQPYWPLLQTWADFLVASLPYPGNELCTDDFEGPSPNNTNLSVKGILGIGAYSLLLGLNNDHVGAAKYFAIAQN 546 
XP_004365368    476 GAPLTYLQPYWPLLTTWANYLVASLPFPTSQLFVDSYGTASANNVNLAMKGAIGVGAYSLLLSLTGNTTAAAQYMNSATS 555 
jcvi:TREAZ_2972 557 FAHEWTANTA--RGDHSALVFDK-QD-GWALKYNLVWDKLFGTKLFDDSLFAKEVQWYIKTQNKYGVPLDSRREYT-KSD 631 
WP_015266520    683 MAKQWMNLAG--DRDHYTLAFER-PG-TWSQKYNLVWDEILDLKVFPEEVADSEIAYYLTKQEKYGLPLDSRKTYT-KSD 757  Echinicola ...
WP_015333805    685 LAKRWMTMDKldDGPHYALTFDKtPG-SWSQKYNIVWDKLLGLDVFPKEVIRDELAFYLKKQQPYGLPLDSRKTYT-KSD 762  Fibrella ae...
CDD00603        686 MGKQWEQMAR--EGDHYRLAYDR-EG-TWSQKYNIVWDKMWGTHIFSDKVMDREFKYYLTKQNKYGLPLDCRKDYT-KSD 760 
CCZ14663        705 MAEKWESMAN--DGDHYRLAYDR-KD-TWGQKYNMVWDKLWGLNLIPNNAMKREVAYYLRKQNAYGLPLDSRSDIS-KTD 779 
3_pfamImport    202 MAKKWEADAR--EGDHYKLAFDR-QN-TWSQKYNMIWDKLWNTNLFGDEVMQREVSYYLKQQNTYGLPLDIRKDYT-KTD 276 
Q8A1W2          825 MAKEWEMAAY--AGDHYRLAFDQ-PD-SWGMKYNLVWDRLLGLNLFPERVIQKETDFYLTKMNEFGCPLDSRHSYT-KVD 899  Bacteroides...
CCY38578        544 MSDKWIRMSE--DGDHYRLTFDK-QG-TWSQKYNLIWDKIMNMGIFPDSVVDKELRYYRTRQNQYGLPLDNRATYT-KTD 618 
XP_004343605    547 YVQTWLTAANa--tDHYNLQFGL-PS-SWSFKYNMIYDRILNLGLFPASVMQTEEAYYAKQMKAYGIPMDSRATFT-KTD 621 
XP_004365368    556 FASQILAQSFs--tDHYLREKGA-AStTWSLKYNLLFDRVLKLGLFADAVMTTEQTFYTPKMGAYGLPVDSTTSANgRVG 632 
jcvi:TREAZ_2972 632 WILWTAAFTKDVKEREALIAPIAAFLHETPDRVPFSDWYDTISAKHYYFQNRTVQGGLFMLL 693 
WP_015266520    758 WVFWTASLADSQAEFEALIGPMWKYANETANRVPVSDWHETKDAHVMNFRARSVVGGYFIKL 819  Echinicola vietnamensis
WP_015333805    763 WIIWTATMADSDRDFRALVEPIWKYANETPTRVPLSDWHETTDAKQVGFQARSVVGGYFIKL 824  Fibrella aestuarina
CDD00603        761 WIMWLAGMAPNAKTFEALMDPVYTYVNETPTRVPISDWHNTKTGRQQGFKARSVIGGYWMKV 822 
CCZ14663        780 WIMWSAAMADTDELFLRFVGPLYKYINETSSRVPISDYYNTKTGNMVGFKARSVVGGHWMKV 841 
3_pfamImport    277 WIMWSAAMANDKDTFLKFVEPIYKYIDETQSRVPISDWHETKTGMMVGFKARSVIGGYWMRL 338 
Q8A1W2          900 WTVWTASLSADRMQFRKLMLPLHKFMNETTDRTPMADLINTDGKTIVGFTGRTVVGAYFIRL 961  Bacteroides thetaiotaomicron
CCY38578        619 WIVWTASLSSDTTTFREFIKPLYRFMNETEDRIPMSDWIFTDKPHHKGFRARSVVGGYFMKM 680 
XP_004343605    622 WESYIAAMGTNd-QFLAIYNKIYLFLHNTTPRVPFTDWYETTTSAQKGFQARPVVGGLYSRE 682 
XP_004365368    633 EQGFVAATGTTa-QFTSIFDKLFLYANTTASRLPLGDYYVVGSGANVDFRAGAFVGGLYARE 693 
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