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Tetracyclin repressor-like, C-terminal domain This domain belongs to the TetR family of transcription factors. It is found in FadR, a fatty acyl-CoA dependent transcription factor that regulates genes encoding proteins involved in fatty-acid degradation and synthesis pathways. Structural and functional analysis indicate that B. subtilis FadR belongs to the TetR family of transcription factors, where it represses five fad operons involved in the fatty acid beta-oxidation cycle. FadR directly binds to upstream regions of the fadR, fadH, fadN, lcfB and fadF genes, and is deactivated by binding with long-chain acyl-CoAs in a similar manner as E. coli FadR. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",