Conserved Protein Domain Family
RSB_motif

?
pfam16294: RSB_motif (This model is not part of the current CDD release)
RNSP1-SAP18 binding (RSB) motif
The RSB motif on the Acinus protein is the core around which the ASAP complex is built. The apoptosis and splicing-associated protein complex, ASAP, is made up of three proteins, SAP18 (Sin3-associated protein of 18 kDa), RNA-binding protein S1 (RNPS1) and apoptotic chromatin inducer in the nucleus (Acinus). The ASAP complex appears to be an assembly of proteins at the interface between transcription, splicing and NMD, acting as a hub in the network of protein-interactions that regulate gene-expression.
Statistics
?
PSSM-Id: 522277
Aligned: 19 rows
Threshold Bit Score: 62.4761
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002039062  588 KDRLDSRsrdaERAGQERKRSrdr--------egrGRDRERp-dRNAHARSRSGSPASKtKKKENEPP-IRLLDDLFRKT 657 
XP_002430140  772 RHRDDRY-------ERKIEYDrekr-------ddyDDKRRRd--KDRNRRSTSAEPSRKtKKKNEEETpVKLLDDLFRKT 835 
EGT32529      419 RKRERSEtppfSRGAGFMDVKkaky-------edeDRGRRRt--DSHSDDRRRELV-------KEEPP-KKSLEELFKKT 481 
P91156        463 RKRKRSEtppfSRGAGFMDEKkar---------neeRERRR---EGPRSEERRKVV-----VEEEEAP-KKSLDQLFKKT 524  Caenorhabditi...
XP_008193653  728 IGK------------KDVRRDrsrs-------rerSRKHRRt--PSPSDDFITRKQ----RKAEDSVP-QKLMDDLFLKT 781 
XP_031778495  814 LGKEDG-----QLHVKEKERErkef-------ekkKRQRSR----SPVIEVHLPAPARKfKKKEEEPPtAKLLDDLFRKT 877 
XP_011257514  747 LGKEDG-----QQHIREKEREkkeh-------dkkRRARSR----SPALDAHLSAPARKfKKKEDDPPpAKLLDDLFRKT 810 
1_pfamImport    5 RGKLEDMngdgEKDDKRIKRKisdd-------phaTKDKKLkkdEKDLQDKRKKSK----SKTPDRIP-TKSLDELFRKT 72  
XP_005994481 1632 RGKVREY----KHEEGRRSRSr-------------sRDRRRk-eRAKSKEKKSEKK----EKAQEEPP-AKLLDDLFRKT 1688 coelacanth
XP_029695448  348 RDKVREF----ARPGEEERRSrsrdrerrrrergksKERK------------AEKK----AEKADEPP-AKLLDDLFLKT 406  torafugu
XP_002039062  658 KGTPCIYWLPLTPEAIAEKEAFRQKRIEE 686 
XP_002430140  836 KATPCIYWLPLTPEQISVKEEMRRKHMAE 864 
EGT32529      482 IAQPSIYYLPLTDEQVAEKEAKKKEKNTe 510 
P91156        525 VALPPIYYLPLTEEQIAAKEAEKSAKGKE 553  Caenorhabditis elegans
XP_008193653  782 KATPSIYWQPLSPEEISMKQQQRLIRMEE 810 
XP_031778495  878 KATPCIYWLPLTNEQIIVKEEMRRQHMAE 906 
XP_011257514  811 KATPCIYWLPLTNEQIVVKEEMRRQHMAE 839 
1_pfamImport   73 KTTPTLYWSPLSIEQIAEKEDQRRKHLAE 101 
XP_005994481 1689 KAAPCIYWLPLTDEQIVQKVAERAERAKE 1717 coelacanth
XP_029695448  407 KAAPCIYWLPLTEEQVLQKLLDRTERQKE 435  torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap