5J5C


Conserved Protein Domain Family
DCB

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pfam16213: DCB (This model is not part of the current CDD release)
Mon2/Sec7/BIG1-like, dimerization and cyclophilin-binding domain
DCB domain is found at the N-terminal of Mon2 and BIG1-like proteins from metazoa, and in fungal homologues like Sec7 and Gea1/2. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis. This domain is sufficient for targeting BIG1 to the Golgi.
Statistics
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PSSM-Id: 522254
Aligned: 21 rows
Threshold Bit Score: 148.167
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5J5C_B         29 HHSQLRKACEVALEEIKAETEKQS-PPHG------EAKAGSSTLPPVKSKT--------NFiEA-----------DKYFL 82   human
XP_020430965   15 NGLGLLTVLQTELRSISQEARSKFpAIKE------ASERGILKLKYIEEQStsietlivAL-SKs----------EDVLK 77  
XP_003284925    3 KLKSLLSVIVSDLRTISQEGRNKFqNIKD------VSERVILTIKYLEEQSttseqlmqNLkIKs----------EEIIK 66  
Q55BA7          4 NKSALLSFLEMDLRNISSEARNKLlNIKE------ASERGILYIKYLQEQSatpeillqNLkSKs----------DEILK 67   Dictyostelium...
XP_007404102    5 asSSSLALLVSDFQALASETKRKHaDVREvnttpsTSSKFSIALNLLRSTPd------qVLaSFrkkttppstyvEDIIK 78  
XP_004178094    8 QFFTLQKLLNNDLHNLVSESRRKNsEVKH------TSDKALEILKTCHSNL--------DLkRH-----------PDFII 62  
XP_003955404    7 QFSSLYKQLDTGLHSLSSEAKRRNsEVKH------ASEKSLKILKTVHDSG--------DFlRH-----------PDFVV 61  
XP_003668010    5 kfTSFRKQLDQELHSLSSESKRRNsTIKH------ASDKSIDILKTIQNIE--------ELvRH-----------PDFVT 59  
XP_009030873   12 GDKKLLDPLIADLITLSFECKRKYqPIKE------MAEACQLRVRGIGARNenv---laGLmSAs----------TEIIQ 72  
3_pfamImport    2 SGKRLLDSLQMDLRNISSESKRRHpTLKE------AAEAGIVKLRSVSNKHpdl---rlALlSEs----------PELLE 62  
5J5C_B         83 PFELACQSKCPRIVSTSLDCLQKLIAYGHLT---------GNApdsttpgkklIDRIIETICGCFQGpqTDegVQLQIIK 153  human
XP_020430965   78 PFLMSCDTKNQKMVSIAIGSILKLISQSAVS---------ITT----------LPLILSKMSMLIDIg-SEepVQLKVLQ 137 
XP_003284925   67 PFLMALETKNQKMISIAIGSILKLISHSSIS---------INS----------LPLILNKMQMLIDVg-SDesVQLKVLQ 126 
Q55BA7         68 PFLMALESKNQKMISLAIGSVLKLISHSAIS---------NSS----------IPSILSKMQLLIDVg-SDesIQLKVLQ 127  Dictyostelium...
XP_007404102   79 PIFMGCGTKNVKVVAIALGSLQRLISMDVMPpvnkwtylkSFK----------IPQIVAILTSVLPLg-VE--IQLRILQ 145 
XP_004178094   63 PLIKACSSKSAKLTTIAMQCLQRMSSVDCIP---------DSR----------ISQVLDSFIEATLLa-SD--IQLKVLQ 120 
XP_003955404   62 PFVLACSSRSAKLTTIGLQGLQNLSSTNCIP---------KDR----------LIEVLDGFIDATHLa-ME--IQLKVLQ 119 
XP_003668010   60 PLVLACSSRNAKLTSIAMQCLQGLASVPSIP---------ESR----------IPEVLDGFIEATQLa-ME--IQLKVLQ 117 
XP_009030873   73 PFIMGCDTKNPKVVQMSLTAIQRLISQKVVS---------EEA----------AKSIVISLWLLMEAr-VE---ELKLLQ 129 
3_pfamImport   63 PFCMACETKIPKMVQIALNGIQRLITYEAVS---------STA----------TVHLINCLWNLMENe-IE---ELKLLQ 119 
5J5C_B        154 ALLTAVTSQHiEIHEGTVLQAVRTCYNI--YLASKNlINQTTAKATLTQMLNVIFARM 209  human
XP_020430965  138 GLLILITTLH-DLHDDLLAQCLVLCFRL--HCSKNT-SIQKTSSATLPQITRIIFDRV 191 
XP_003284925  127 GLLVLITTMG-DIHDDTLSQCLVLCFRL--HCSKNI-SIQSTSSATLPQIIRIIFDRV 180 
Q55BA7        128 GLLVLITTVP-DIHDEELSQLLVLCFRL--HGSKNT-SIQSTSSATLPQIIRIIFDRV 181  Dictyostelium discoideum AX4
XP_007404102  146 TLPSLFTRCSlYLHDTLLADALLLCFRL--QDSRIG-VVSSTSAATLRQLVMVVFEGV 200 
XP_004178094  121 IVPIFFKTYGkYIYGPLCAKLLTCCSNLlqVPNKSP-MVIGTASATMQQLIDEIFERL 177 
XP_003955404  120 VVPIFFKTYArYIHGQVCMKLLQCCSVLlqLPQKSS-IVASTASATLQQLVDEIFERL 176 
XP_003668010  118 IVPIFFKTYAkYIVGPQCKKLLQCCSSLlqLPNKAP-VVFGTASATLQQLIDEVFERV 174 
XP_009030873  130 TAILLITTND-VVKHEVLAKALALCFRM--HFAKDS-TTTNTAAATVRQLVAAVFDRV 183 
3_pfamImport  120 TMTLLISTND-IVQGETLAKGLALCFRL--HFTKNQ-TVNNTASATIRQLVSFVFERV 173 
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