Conserved Protein Domain Family
Peptidase_M16_M

?
pfam16187: Peptidase_M16_M (This model is not part of the current CDD release)
Middle or third domain of peptidase_M16
Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolise several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Statistics
?
PSSM-Id: 522231
Aligned: 207 rows
Threshold Bit Score: 136.553
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
ESK94169      435 FRFIEKRKPDDYATRIAENMakpYPRELLLVAPSVTWN-WGdqyesgpilsggtagEEKIKEYLQG-FQIDNSRAVLMGK 512 
WP_012488743  419 FDNAPKPQPLQQAVGLTMSQf-dLPVENLLNADYVYER-YD---------------PKAIKSLLAQ-LDKRRARIWYINP 480  Cellvibrio ja...
XP_004027688  330 FDFKEKSDPLNLVVNLSKIMh-dLPIENVLQYPYLMET-FS---------------FEKIQEIVQN-FTLENLLIVHSSP 391 
A0DFS2        359 FDYLEKQNPFDFVGALASRLh-qYPITDILKAPYLMEN-FD---------------SNLINNTINQ-LKRNNLNVFLQSQ 420  Paramecium te...
A0C9C8        410 FDFLEKGDPFNYVCTLASRMq-qYPIEDVLRQPYLMEQ-YQ---------------PELIQKITNQ-LTGDRLMMFLSSQ 471  Paramecium te...
XP_004031142  371 FQYKEIEEPIDYTYILASKMq-tCDLQDILRYDALLES-FH---------------KEDMEATLND-FQLKNLRINITSP 432 
XP_004031173  372 FNYNEQMEPINYVSKIASKMq-yCKQEDILRFEAVEEEvFN---------------QQQLQQTFEQ-IKIDNILINLISQ 434 
XP_001024563  378 FNSAEQEESMDFAHSLTANMq-iYKPKDIIKAQCYFEE-YD---------------PQLINQVINS-FKHENMRIFFSSQ 439 
XP_001024628  370 FDNVDKQKIMQYILTLASKLq-yYEIEDILVQPYLFES-FD---------------KELIQKYIDS-LKTSNLRIFLQSK 431 
A0EAP0        439 FDYNEn--IIDDIQEIAHNLn-fYGFHDVLSRKYLYED-YD---------------PELIYFYLTElLDIDNLNVFLGDS 499  Paramecium te...
ESK94169      513 qqe-ldkVKRfdstiEKWQEE---PWYGTKYRVERF-PED---FVKAARcs---daTSTIPELFLPGPNQFIP------- 574 
WP_012488743  481 g----------------vETDkpiPYFDGTYALRET-RAD---EYTRWAsl---saG-Y--RFNLPPLNDLFTdkpapiv 534  Cellvibrio ja...
XP_004027688  392 lfsqeecN--------LI--E---NHYQTNYSIQNF-SQEieqIYQn---------PLNCTNIGLPPKNIFIP------- 441 
A0DFS2        421 -------QFQg----KLGNFE---KYFGTEYEISDLqFEN---LQARNQ-----------N-FHLPNLNIYLP------- 464  Paramecium te...
A0C9C8        472 -------TFSn----QLGNKE---EYFGTEYSQSKF-LED---VTSVFKna----aNNISPKLNLPPQNIYIP------- 522  Paramecium te...
XP_004031142  433 -------LLVn----QCELLE---PIYQIKYKVEDI-EDE---LIKIYQnp----qEKYIKKFDLPPQNTFIP------- 483 
XP_004031173  435 -------QFKn---eELNLEE---YYYKTKYSIQDL-EQD---IIEDFKk-----eRNQQLNLDIPQLNQFLP------- 485 
XP_001024563  440 -------TLEs----ECTQVD---PYYFCKYQQSPL-PQN---IIDLFInptynhtTCGGKQLGLPPKNDFIA------- 494 
XP_001024628  432 -------TQEs----LCNLTE---PIYGTKYSCENF-DET---TIKSFEnpd-lsfTKSQKKLDLPPPNDFVP------- 485 
A0EAP0        500 qlnhpdvQ---------Y--D---KVNRINYAFVDI-PNSviqKIQsy-------dEIEQPKFELPSIHKYQP------- 550  Paramecium te...
ESK94169      575 QNLDVDK---------------------------------KE----ID--TPLRRP--YLIWDTSVCRVWHKKD-DRFWV 612 
WP_012488743  535 ESLYL-------------------------------------------------KP--QAVVSAAGVEAYLVHP-EHYRE 562  Cellvibrio ja...
XP_004027688  442 ENFEV------------------------------------I-----KeeSVGNFP--KIIYEKENMRAYFKGDdGIFKT 478 
A0DFS2        465 NQTDLLAn--------------------------------PN--------S-QQYP--TIIYESPQSTVYFKQD-NKFNV 500  Paramecium te...
A0C9C8        523 EHTNVLPl--------------------------------QN--------GLPLFP--ELVLQNEQTDLWFKQD-DRFQV 559  Paramecium te...
XP_004031142  484 KVFHLLNle------------------------------vEN--------PEKSDI--KYIAKGTNYEFWYKKD-NYFKI 522 
XP_004031173  486 KSFDL------------------------------------------IesENQQYP--INLLKNEKLELWYKKD-NQFRI 520 
XP_001024563  495 KDLSLITq-------------------------------dYE--------NLPKYP--SVIKQDEKSIAYFKQD-HKFKV 532 
XP_001024628  486 KSMTIFGsk------------------------------nDE--------TQSKLP--VQIQD----NVWFKQD-NTFLT 520 
A0EAP0        551 NDLNMKSfckpyqsskedpyedlqnekmliqrnsemvfsnVEeclkYEhqYEELYPlpEYLFKSSIGKLWWKLD-RSYKT 629  Paramecium te...
ESK94169      613 PKAHVVID--IRSRFA--DPTPRATVLTRLFTDLITDSLAEFSYDADLAGLSYSCTSHSKG-LYIALQGYNDKMYVLVKQ 687 
WP_012488743  563 DKGALSVQ--INVDFA--KSSARQAVLAELLNEVYNKQNVTLVDRAGRASLGVNLYLTVTSsQGISIQGYTTKHEQLLTQ 638  Cellvibrio ja...
XP_004027688  479 PKGVFQLNiyYKIQNSflFTKEERILFNYIYYSLFKNFIREIQYMAQLANLVDSYLFQRRK-ITLNCQGFSDKLLDYSYE 557 
A0DFS2        501 PKTFIKMRqyLDSM----GKSIQNEVLGALWQSLLTIHLRELFYEAEVASLSPSVSLVTNG-IEYSLAGFSDSINKFLPD 575  Paramecium te...
A0C9C8        560 PKTVIQLR--INTIETgyGKLAKTEAIAKIWLALLKNHVREFNYLAEMAKIDATLQLAANG-LEFSISGFSDSISRFVIG 636  Paramecium te...
XP_004031142  523 PKISLLIK--FFHESF---FTLKNQILCEVYISIILEKNRELIYQGEMACIETILEFKN-E-INFIFESFSDNFYIFLEQ 595 
XP_004031173  521 PKVVFKLR--IKNNDCglGKNAQAQVLAELWISLFQEYTRELAYLGKTAGLETKIEFIDE--IQLEIVGFSESIQTFIQQ 596 
XP_001024563  533 PKTLAKVI--IYSNDGnvKENVENYLLYQIWMKLFQEENREFMYQAEMAKIYTKMYIKG-T-AEIEFEGFSETLPSYLNA 608 
XP_001024628  521 PKGQISLF--IYFKDCdlPHNVQNVLHSKIWELLFNHHVSELTYMAEQAYLSFRMAITPLQ-LKLDFKGFNDSLPRFTLQ 597 
A0EAP0        630 PAIFMGMK--IDKINF--QFTLRQQVLLKVFQSYTSTMISQHLDAAFQNNYNFKFTSSPNH-IIFNIYGWNDK---FFEF 701  Paramecium te...
ESK94169      688 VLNRVKn----lTVNPDRLNVMK-EQ--NKKN--WENFFLNQSYQLANY-YTSYLMS-ETAWTMEELLKE 746 
WP_012488743  639 LLQSFVa----lEINEQRFAEAV-DT--LQKN--LANRSKDHVFRQLFS-HLGRVVT-QQSYSPDEQLAA 697  Cellvibrio japonicus
XP_004027688  558 IVQKLIsf--nsQNNQEFFEFSNfERflQKKLllLQNFYIQSPHNFEDH-FCNNLLDnNT-------EEK 617 
A0DFS2        576 MLRKVLdfrv--enyRDNYDTQL-AK--LVCD--LENFSHSPPYSQARN-LSMLLLRdCGSFDPEDLLQT 637  Paramecium tetraurelia
A0C9C8        637 MFQKIIsfkp--qdyQDLYESTF-VK--ITQE--LENIKRSQPYQQVHS-LMTVVLReGSSFETQELLDQ 698  Paramecium tetraurelia
XP_004031142  596 FLTQIVnfdvlkdIQKSIFNIQV-NK--IQKK--YKNFFFKSPYEQGRN-YSEYIMNrFS-FSPEDLLEQ 658 
XP_004031173  597 YLEKTTtfnpk--eiqnkFEIHL-DK--LIKG--KINFSKKPPYEQGRI-YNLFILT-TRTFSPKELSKE 657 
XP_001024563  609 FFERLSkfdp--tpyKQDFLVEY-EK--LSKK--LQNFFCKNPYKQGKY-YNQFAIRhKGLFGPQELLEA 670 
XP_001024628  598 ILEKLVsfnp--lanQELFNNIY-EE--VAKE--TDNFFKNPPFQQIAP-YVDYLVRtGF-HSPQQKAEA 658 
A0EAP0        702 IEDSLAffi-kqQIDQSVYDQTLkT---LMNN--LNEELQTPLYQQIRNrFFFNTLI-QGYYEPQQLLQE 764  Paramecium tetraurelia
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap