Conserved Protein Domain Family
Anoct_dimer

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pfam16178: Anoct_dimer (This model is not part of the current CDD release)
Anoctamin, dimerization domain
This entry represents the dimerization domain of anoctamin family of proteins. Seven members can be divided into two subfamilies; Ca2-dependent Cl(-) channels (TMEM16A and 16B) and Ca2-dependent lipid scramblases (TMEM16C, 16D, 16F, 16G, and 16J). This domain is responsible for creating the homodimeric architecture of the chloride-channel proteins.
Statistics
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PSSM-Id: 522224
Aligned: 153 rows
Threshold Bit Score: 158.472
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
OXA52495       202 YFKDKQRRIDMMLVFEEDL------DFLKEQ------RRKTFLKNLVDEGVEIEIEHPDpTkrrlNHETHFVKVHAPWTV 269 
30_pfamImport    1 FFNDGRRMINYVLVYTENDia---fEGSQDL------QVEYFLSNLEKRGLELESVHG-------GDESVFVKVHIPIET 64  
31_pfamImport    1 YFNDKQRKIDFILVCSSNAl----dSVEHRT------NIMKYIAYLQNNGLQFETEAGM-F----FNNDFFIKVHGPNEV 65  
XP_031332664    14 YFSDGKRRIDFILVYKHSTv-----SAQEKE------YIKTYISNLENKGLHFEMSEGI-K----DDTLMFVKVHGPKKL 77  
28_pfamImport    1 YFLDGKTKVDYVIVIPKLDer--irGDRVQM------QINQFVSQMKDKGLLVERDVGK-F----YTTLVFLKIHAPHKA 67  
14_pfamImport    1 YFNDGKTKVDYVIVYPKLEeh--vrGDQMEL------HINKFTSGLKEKGLLVEKEVGK-F----YDKFVFLKIHAPHKL 67  
XP_018335154    20 CFRDKKRRIHLVIAVSAGN---------IDE------KLGVFVENLKSQGVHVEEDFGV-Y----DNEIKFIKLHLPDDK 79  
CAD5126106      48 FFRDGRRRIDFIITYEDLPnse-ddLQFKLL------QKLKFEEELQNHGIELEVEPKT-Ns--vNQTTNFIKLHVTWDG 117 
CAD5113431      16 FFRSEHKRIDYIIVYQDYPkse-edYNIRTK------QRKEFEKNLISKGLELEYDPEPdSedynRRKYKYIKIHASWKC 88  
XP_032221045    35 FFNKGGHKVDYVLVYETCQeredkdPKFAAKmadferKRDAFEAALSEQGLVIERESIT-SpqndKVKRHFVKLHVPWRT 113  starlet sea ...
OXA52495       270 LTKYAEIMNMKMPIKDnkp-sgeDfleEVTCWKQIRSKf------------KI-FDYNHQLIPAEPSFFMASFSRQKEEC 335 
30_pfamImport   65 LYYEMKQQRIHFTCI------------LPFEAFIPASKf----------------------TCMNIQYDRRIQKRNLESV 110 
31_pfamImport   66 LLRYAKAFNVPLEFQs------qR---IYIEQKNYWTFlh----------tRI-MRPDPDD---------PIFNRAKETL 116 
XP_031332664    78 LTNYAEALGVPLACT------------------SLYYQv-----------eST-TKYEIMKTD-ITNPNSITFSRALKSL 126 
28_pfamImport   68 LLRHANIYNVQLTCQn-------P---YYKYRERICNLlt----------tEL-TKPNPESEV---------YRRAEK-T 116 
14_pfamImport   68 LLRFAKVFNVELACN--------------NPYHKFWESvy----------sRC-LATHVTKLNSNSKIYS----RAPKT- 117 
XP_018335154    80 AAAFAKAYQIDCYYERrq----fW---TEQNPNSYLRKf------------FP-FHETSVVVNERNP-------MYQKST 132 
CAD5126106     118 LVRGAELIKLQKRLKf-------E---MRSDLEDFGADca----------mCPcFLPNEVITGPDDDFFSAIFTKKDMNL 177 
CAD5113431      89 LLEGAEKLALQKRLKHssnrideA---LNTNCLSCSCRnf----------tG--FPPLPEDIECEPNYFTAPFDNDDIEQ 153 
XP_032221045   114 LSSKAEELMLKAPLQEn------D---I--DLKTTGEKifghrfmdglrrlDP-FRIKDSSIPEKPKCFMAYFKERKVDK 181  starlet sea ...
OXA52495       336 FII--KDRETFFTPAQRSQIAWKIMTRVRFddgg----dekVGVQLTGIRRLLNDKTFNASFPLHEGPYN--------ED 401 
30_pfamImport  111 FGL----QPQEPTSAEKIMVIHEILNTTKFg----------eRDEDYNLDEIIKLGVLTTAYPLHDGTCTw------sNQ 170 
31_pfamImport  117 -SG---ERPTKITEIERIMIVHMLLSRAVFg----------DKCNEHGIEKLKQRGTFIAAYPLHSGQWEw------tVR 176 
XP_031332664   127 -KG---EKPSRISTMERAIVINKLLNTTQFg----------PDEFECGISKLIKKKIFIAAYPLHAGNWRw------tEE 186 
28_pfamImport  117 LSG---KRPASITTFERSQIVLKVLNNISFl----------FEDDEITFETLLDKEIFLQAYAIHDGDGDw------tDE 177 
14_pfamImport  118 LSG---ERPTEITTAERSLIVYRLLQSIKFi----------INGDEIDIKRLLRQEIFLHAYPIHDGDYLw------tDS 178 
XP_018335154   133 FEL--NKSPTSITYSEVSYVLYKLLNETHFg----------DKQFEFGVDRLLNKKIALSIYSLHEGQWQw------tVE 194 
CAD5126106     178 FDI--QNEESFFTNAERSLIAHEFLQRAKYpen------dkDDTLKHGIAGLVNRGIYKSYFPLHELPPAkikknlqfFD 249 
CAD5113431     154 FDIelENQDEFFTNAERSLIVDSVLAETAFpdyddddeestGNRMTFGIDKLVKLDIYRSCYPLHESLk--------rAE 225 
XP_032221045   182 YMGk-AEPEKMFTALDRHYVVQRICYATRFa----------EGPKGVGLKQLVYEGAYCANYPLHDGDDDvi----geSS 246  starlet sea ...
OXA52495       402 NDPNDRRLLFTEWAHFSNWYKKQPL 426 
30_pfamImport  171 GTLSDRQLLKYYWGKVSRIKNIQPL 195 
31_pfamImport  177 GPLNDRQLLARYWARLKKWYRLQPL 201 
XP_031332664   187 GHLTKLQLLAEFWARLSMWYKEQPL 211 
28_pfamImport  178 GPLTDRQLLCKYWANLRYIFREQPI 202 
14_pfamImport  179 GPLSDRQLLCKYWANLKYVFTIQPV 203 
XP_018335154   195 GGVSSRQILAKYWSNSKMCYKQQPM 219 
CAD5126106     250 GPDVDRRRLVETWARWGKMFHYQPL 274 
CAD5113431     226 SDDEDRRNLRLYWANWKRIFTFQPL 250 
XP_032221045   247 YPSNDRQRLKKDWSSMKRIFKYQPL 271  starlet sea anemone
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