7XHO,7XHN


Conserved Protein Domain Family
CENP-T_N

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pfam16171: CENP-T_N (This model is not part of the current CDD release)
Centromere kinetochore component CENP-T N-terminus
CENP-T is a family of vertebral kinetochore proteins that associates directly with CENP-W. The N-terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes. This family represents the N-terminus of CENP-T.
Statistics
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PSSM-Id: 522217
Aligned: 11 rows
Threshold Bit Score: 512.468
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7XHO_T         1 MAD-HNPDSDSTPRTLLRRVLDTADPRTPRRPRSARAGARRALLETA-SPRKLSGQTRTIARGRSHGARSVGRSAHIQAS 78  human
6_pfamImport   1 MADsYSQDSEPTTRTLLRRVLDTADTRTPQRRRSAGIGAQKSLLETP-SSRRLSSSTKTNARRRSQRARSIGRLAHVQTS 79 
5_pfamImport   1 MAD--NWDSEPTIRTVLQRVLDNADSRTPRRPRSSGAGAQRTLLTTS-SSRRLSSRTKTSAKQRSHGVRSIGRLAHIQVI 77 
Q3TJM4         1 MADlSFSDGDPTVRTLLRRVLETADSRTPMRRRSTRINAQRRRSQTP-YSNRQGSQTKTSARKQSHGARSVGRSTRVQGR 79  house mouse
Q561R1         1 MADlSSPDGDPTIRTLLRHVLDTADSHTPRRRQSTQTNPQRRRSQTP-YSKRQGSQRKTSTRKHSHGTGSVGRLARVQGH 79  Norway rat
1_pfamImport   1 MADsGSPDSEPTTRTLLRRVLDTADPSTPRRPRSARAGAQRALLETP-SSRRLSSQTKTTARRRSQRIRSIGKLAHVQAS 79 
2_pfamImport   1 MADsKSSDSEPTTRTLLRRVLDSAVPRTPLRPRSARTSAKRALLETP-SSRSLSSQRKVTARRQSHGARAIGRWAHVQAR 79 
4_pfamImport   1 ARR---ADREPTPRTLLRRVLDTADPRTPRRPRSAGAGAQRSLLETP-SSRRLSSQRKTTARWHSSGAKSVSRLPHAPTS 76 
XP_009429245   1 MAD-DNPDSDSTPRTLLRRVLDTADPRTPRRPRSARAGARRALLETA-SSRRLSGQTRTIARGRSHGARSIGRSAHIQAS 78 
EGW10111       1 MAGrYSPDPDQTPRTLLRRVLDTADSRTPRRRQSVRNNAQRSLLQIPsSSKRQSSQTKIVARRHSYITRSVVRLARVQTH 80 
7XHN_T         1 MAD-HNPDSDSTPRTLLRRVLDTADPRTPRRPRSARAGARRALLETA-SPRKLSGQTRTIARGRSHGARSVGRSAHIQAS 78  human
7XHO_T        79 GHLEEQTPRTLLKNILLTAPESSILMPESVVKPV--------PAPQAVQPSRQESSCGSLELQLPELEPPTTLAPGLLAP 150 human
6_pfamImport  80 GHLEEQTPRTLLKNILLTAPESSIMMPESVVKPV--------PTPQVVQSSRQESIRGSLELQLPELEPPTTLALGLLAP 151
5_pfamImport  78 GNLKEQTPRTLVENILITAPKSSILTPEAMVKPV--------PALQVVQPSRRESSQGSLELQLPELEPRTTLAAGLPAS 149
Q3TJM4        80 GRLEEQTPRTLLRNILLTAPESSTVMPDPVVKPA--------QVPEVARSSRRESSRGSLELHLPELEPPSTLAPGLTAP 151 house mouse
Q561R1        80 GHLEEQTPRTLLQNILLTAPESSTVMPNPVVKPA--------QVPEVARPSRRGSSRGSLELQLPELDPPSTLAPGLKAP 151 Norway rat
1_pfamImport  80 GYLEEQTPRTLLKNILLTAPESSIVMPKSVVKPG--------PAPQVVQPSSRESSRGSLELQLPELEPPTTLAPGLLAP 151
2_pfamImport  80 GHLEEQTPRTLLKNILLTAPESSIVMPESVVMPVvqpsrrstSGPQVVQPSRRESSRGSLELQLPELEPSRTLAPGLLAS 159
4_pfamImport  77 GHLEEQTPRTLLNNILLTAPESSILMPESVAKPV--------PEAQVAQPSRRKSSQGSLELQLPEPEPPAPLPQGLLAP 148
XP_009429245  79 GHLEEQTPRTLLKNILLTAPESSILMPESVVKPV--------PARQVVQPSRQESSCGSLELQLPELEPPTTLAPGLLAP 150
EGW10111      81 GHLEEQTPRTLLKNILLTAPESSIVMPDSVVKPV--------QVPEMVESSKWESSPGSLELQLPELEYPSTLAPGLPAT 152
7XHN_T        79 GHLEEQTPRTLLKNILLTAPESSILMPESVVKPV--------PAPQAVQPSRQESSCGSLELQLPELEPPTTLAPGLLAP 150 human
7XHO_T       151 GRRKQRLRLSVFQQGVDQGLSLSQ-------EPQ--GNADASSLTR-SLNLTFATPLQPQSVQRPGLARRPPARRAVDVG 220 human
6_pfamImport 152 GRRKRKLRLSVFQQGIDQGLPLSQ-------EPC--GNTSASSLTS-SLNLTFATPLQPQSVHRPGLARRPPTRRAVDVG 221
5_pfamImport 150 DRKKQRLRLSVFQQEVDQGLPHLTp-----rADR--GIPLGTLGLT-SFNLTFATPLKPQSVRRPGLARRPPRPRAIDVG 221
Q3TJM4       152 GKRKQKLRLSVFQQEVDQGLPLSQ-------EPRrsRSADVSSLAS-SFNLTFVLPGQPETVERPGLARRRPIRQLVNAG 223 house mouse
Q561R1       152 GKRKQKLRLSVFQQEVNQQLPLPQ-------EQR--GAADGSSLAS-SFNLSFVPSVQPQTVDRPGLARRRPVRRPVNIG 221 Norway rat
1_pfamImport 152 GRRKQRLRLSVFQEGMDKGLPLSQ-------ESR--GNADASSLTS-SLNLTFATPLQPQSVQRPGLARRPPTRRAVDVG 221
2_pfamImport 160 GRKKQKLRLSVFQQGVDQGLPLSQaccraltEPH--GNADASSLTStSLNLNFATPLQSQSVGRPGLARRPPTRRAVDMG 237
4_pfamImport 149 GKRKQRLRLYVFQQGVDEGLPLSH-------EPR--GNPDASSLAS-SLNLTFATPLQPQSVHRPGLARRPPTHRSVDVA 218
XP_009429245 151 GRRKQRLRLSMFQQGVDQGLSLSQ-------EPQ--GNADASSLTR-SLNLTFATPLQPQSVQRPGLARRPPARRAVDVG 220
EGW10111     153 GRSKQRLRLSVFEQEVNQRLPLSQ-------EPP--GNADASSLTS-SFNLSFVPPCQSQSVGRPGLARRRPIRRPVDVG 222
7XHN_T       151 GRRKQRLRLSVFQQGVDQGLSLSQ-------EPQ--GNADASSLTR-SLNLTFATPLQPQSVQRPGLARRPPARRAVDVG 220 human
7XHO_T       221 AFLRDLRDTSLAp---------------pNIVLEDTQPFSQPMVG-SPNVYHSLPCTPHTGAEDAEQAAGRKTQSSGPGL 284 human
6_pfamImport 222 ALLQDLQDTSLAla-------------spDTVLEDTQPFSQPLVGhSPSVYHSLPCLSYTEAKDAEKAVSHRTQRSGPKL 288
5_pfamImport 222 ALLQDLQDNSLAlappgdslktpianlpsDTVLEDTQPFSQPLVGcSPSVHRSLPNPFPTGTEDAERTTGDRTQSSGPGL 301
Q3TJM4       224 ALLQDLEDNSLAsalpgdshrtpvaalpmDVGLEDTQPFSQSLAAfSLSGKHSLPSPSRPGVEDVERVMGP--PSSGTRL 301 house mouse
Q561R1       222 AFLQNLENKSLTsalpgdshrtpvaalptDVVFEDTQPFSQPLAGcSLSVHHSLPNPSQTEVEDAERVVGPRTPSTGTRP 301 Norway rat
1_pfamImport 222 AFLQDLRDTSLAla-------------ppDTVLEDTQPFSQPLVGrSPSVHHSLPCPSHSGAEDAERAVSHRTRSTGPRL 288
2_pfamImport 238 AFLQDLRDTSMAlvspgdshrtpiatlqkDAVLEDTQPFFPPLVGrSPSTHCSLPGPSHTGAVHAERAVGRRTWS-GPGL 316
4_pfamImport 219 AFLQDLRDTNLAp---------------pNIVLEDTQPFSQPLAGcSPSMHGSQPLPSHTGAEDTERVASPRTWSSGSRL 283
XP_009429245 221 AFLRDLRDTSLAp---------------pNIVLEDTQPFSQPMVG-SPHVYHSLPCTPHTGAEDAEQAAGRKTQSSGPGL 284
EGW10111     223 VLLQDLEDNSLTtalpgdnyrtpvatlptDAVLEDTQPFSQPSVGcSLRVYHSLPSPSHSEVKGAERVVGRRTQSTGTGL 302
7XHN_T       221 AFLRDLRDTSLAp---------------pNIVLEDTQPFSQPMVG-SPNVYHSLPCTPHTGAEDAEQAAGRKTQSSGPGL 284 human
7XHO_T       285 QKNSPGKp--------aQFLAGEAEEVNA------------------------------------------------FAL 308 human
6_pfamImport 289 QNHSPVKpaqllagkskKVDALAMSFPNTssaiagedeveplqggvgen--------aeermeeslsvsevkdttgtQGS 360
5_pfamImport 302 QNHSEYWgs-------pCCSIFTLLGATA------------------------------------------------LAC 326
Q3TJM4       302 QSRMSRS----------GPAASPSPFLEP------------------------------------------------QPP 323 house mouse
Q561R1       302 QSQMSRA----------GFGASPLPFSEP------------------------------------------------QPQ 323 Norway rat
1_pfamImport 289 QNNSPGKp--------aQLLAGKAEERTEkslsmskvkea---------------------------arargsaraqEPE 333
2_pfamImport 317 QNNSEWAg--------lGFATPSLPFSEE------------------------------------------------ESE 340
4_pfamImport 284 QNSSPEKpaqflarkakEVNALALGFPNTsnsisgdaveplqdgvgeeaekkmeeeeglsmsevkettgsqgpfraeQPG 363
XP_009429245 285 QKNSPGKp--------aQFLAGEAEEGDA------------------------------------------------FAL 308
EGW10111     303 EKHMSRT----------SLGTTPLPFSKL------------------------------------------------QPQ 324
7XHN_T       285 QKNSPGKp--------aQFLAGEAEEVNA------------------------------------------------FAL 308 human
7XHO_T       309 GfLSTSsgvsgedeveplhdgveeaekkmeeegvsvsemeatgaqgpsrveEAEGhtevteaegSQGTAEADGPGASSGD 388 human
6_pfamImport 361 VrTDKS---------------------------------------------DRNE---------TSEAVEAKEPEGSSGD 386
5_pfamImport 327 FvSEVM---------------------------------------------EAEE---------SQETMETEEPEGSSED 352
Q3TJM4       324 P-AEPR---------------------------------------------EAVG---------SNEAAEPKDQEGSSGY 348 house mouse
Q561R1       324 S-PELR---------------------------------------------EAVG---------SKEAEEPKDLEGSSGD 348 Norway rat
1_pfamImport 334 GhTQVT---------------------------------------------EAEG---------SQGAIETKEPEGSSGD 359
2_pfamImport 341 GhTEVT---------------------------------------------EADG---------SAGAVEAKEPGGSSGD 366
4_pfamImport 364 GhTEVT---------------------------------------------ESEG---------FQGAVETEEPEESKGD 389
XP_009429245 309 GfLSTS---------------------------------------------SGVS---------GEDEVEPL-HGGVEEA 333
EGW10111     325 P-PEIR---------------------------------------------EAVG---------SQEAVEAKEQEGSSRD 349
7XHN_T       309 GfLSTSsgvsgedeveplhdgveeaekkmeeegvsvsemeatgaqgpsrveEAEGhtevteaegSQGTAEADGPGASSGD 388 human
7XHO_T       389 EDASGRAASP--ESASSTPESLQARRHHQ 415 human
6_pfamImport 387 ENISGRTASP--ELASSTTEFLQARQLQF 413
5_pfamImport 353 ENTSDRPGKKpsILPSETREPVSARLTPR 381
Q3TJM4       349 EETSARPASG--ELSSSTHDSLPAEQPpp 375 house mouse
Q561R1       349 EETSGMPASR--ELSSSAQDLLLAEEPHQ 375 Norway rat
1_pfamImport 360 CPTSSRRVSP--ELASSTPEFLQAKRIQG 386
2_pfamImport 367 KDTSNRTASP--QLASSGPKSLQARRLRQ 393
4_pfamImport 390 EDISGRTACP--ELASNTPAFLQTKQRHQ 416
XP_009429245 334 EKKMEEEGVS--MSEMEATGAQGPSRVEE 360
EGW10111     350 EDTPGRPASP--ELAADTYNLLQAEQPHQ 376
7XHN_T       389 EDASGRAASP--ESASSTPESLQARRHHQ 415 human
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