8SRO


Conserved Protein Domain Family
FOXP-CC
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pfam16159: FOXP-CC (This model is not part of the current CDD release)
FOXP coiled-coil domain
This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain
Links
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Statistics
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PSSM-Id: 522210
Aligned: 23 rows
Threshold Bit Score: 98.5257
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8SRO_A          5 LLANGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHL 72  house mouse
XP_069040816  208 LFVNGVCKWPGCEELFEEYSLFLQHLYSDHSPGEKSMAQWRVQKQVVLQMENQLAVEKQRLVAMQLHL 275
10_pfamImport   1 LFVNGRCRWPGCDEPFEDFPVFLKHLNHGHSCGEKAIAQWRVQQERVRHMENQLIQEKQRLQAMQLHL 68 
4_pfamImport    1 LFVSGFCRWPGCDVMSEDFPSFLKHLHSEHSHGEKSIAQWKVQQDIVQCMESQLILEKQKLIAMQLHL 68 
7_pfamImport    1 LFVSGLCRWPGCGAVSEDFPSFLKHLQSEHGRCDRSLAQWRVQQDIVQCLETQLVLEKQKLFAMQLHL 68 
XP_023197615   89 LFVSGLCRWPGCGVILENFSTFLKHLHSEHRHNDKSIAQWRVQQDIVQYMERQLVLEKQKLLAMQLHL 156
EGT55992       87 LWQHSMCAWPNCDQPCDSVMALIAHLQQEHPPCDRTNEEMRAQIEKVESLEHKLSVERNRLQGMMQHL 154
1_pfamImport    1 LWQHNMCAWPNCETACDSVVALIAHLQHAHQPSDRTTEEVRAQIEKVDSLEHKLTIEKNRLHGMTQHL 68 
XP_056665062   36 LDSSQSCWWPGCEKVFLEPGELLKHLQEDHRLDEKGKAQCLIQKEVVQNLEQKLLLEKEKLGAMQAHL 103 gray short-tailed opossum
XP_039768326  215 LLANGACRWPGCEKVFEESKEFLKHFHTDHRMDEKGRAQCLVQKEVVQSLEQQLVLEKEKLSAMQAHL 282 platypus
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