Conserved Protein Domain Family
THOC2_N

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pfam16134: THOC2_N (This model is not part of the current CDD release)
THO complex subunit 2 N-terminus
This family represents the N-terminus of THO complex subunit 2.
Statistics
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PSSM-Id: 522200
Aligned: 74 rows
Threshold Bit Score: 361.561
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EMR68761      113 TEARLSAWrQNGRQEVVDHGI-TSRSDEDVEEISTISQEFTRAVLENRLR------PTDAGECVKQILGSEIENNdvtgf 185 
XP_022466264   33 kkveteGW-SAKCESLITQLGaIEDDAERIQWFKKVLGELLMMVL-DKEFgsgglsLQNVADFIDSLGKVPPTDSkv-et 109 
XP_001646433   24 TTEVIDNW-ETKHEELCNQYLgFDGVEEKSRWLKSIFVECFRLYYQENEDhf--ltAEQISKFVTRLVEVSKD------- 93  
XP_003687075   24 SEAFINDW-SSKSLELISQYLeVTDVDEKHDWLRNFFIELFQILYLPNLPnn--vtIQLLAQLINELVQKSNDS------ 94  
CCE90618       25 DEESLNNW-PSKAGDYSSQFKaTENNEEKEKWLKDLFIELFELF--QKPElpakltLQQISSFIDDISSSTGIISsq-el 100 
6_pfamImport    2 TEEAVQNW-PQRSRTLCSEFFaLESNDEKEDWLRIVFIELFEFI--NKGEenfilkLSDIALFIEELVNNDRQAPq---- 74  
P53552         30 TEEVIRNW-PERSKTLCSDFTaLESNDEKEDWLRTLFIELFDFI--NKNDensplkLSDVASFTNELVNHERQVSq---- 102  Saccharomyces...
Q754L4         23 TDEFLKDW-ATNADRLIAEYRtLAKASEQVDFVYRVFAEGLLFT--QGALrglvgdYGPLASLLAALCEN---------- 89   Eremothecium ...
XP_003647570   23 TDEFLKDW-QGNSSKLLERYDsIEESSEKDNLIYDIFNEAMVFTN-KEFKdllnddYGMLGEFLSKLCEKN--------- 91  
XP_002552039   49 aqiedqnW-ELFTQEVINNLKsSSDQADKKNRVQSVLYEIVLLS--SESNtqrpldSEKVLQLIKDMHAVE--------- 116 
EMR68761      186 GFDARILFVDTLSIF-----LESDDttvkpqlRDFIV-----ATGLPPQLLREMMDASALQQLGL---IRDT--FHRLGI 250 
XP_022466264  110 VSIIGKLYVAITSYIpgvvpNSEAE-------TQVIEltklvTSIHGEVYKFSALTSKIN--------TKEQnvLLRHLL 174 
XP_001646433   94 SGRIGKMFIASSSTS-----NDEEV-------SKLISlmkliSSIEEEMYKYSWVSGKIM--------VKDQksILKHRL 153 
XP_003687075   95 SELIGMAFVSASSTY-----SKEDD-------NRLLLlakeiPVLYDELFKFSPISSKLM--------TKDQmvLMRHLL 154 
CCE90618      101 CSLVGKMFIAVSNQF-----ADGDD-------SKVIAlarinNLLSKEIYKFSRVSSKLM--------TSEQtiLLRHLL 160 
6_pfamImport   75 ASLVGKMFIAVSSTV-----PNIDD-------TNTISlcrliPSLHEELFKFSWVSSKLL--------NKEQttLLRHLL 134 
P53552        103 ASIVGKMFIAVSSTV-----PNIND-------LTTISlckliPSLHEELFKFSWISSKLL--------NKEQttLLRHLL 162  Saccharomyces...
Q754L4         90 SSANARILANLINCFp---rHGGDE-------ANMVEllqqlTGMDFE------FSASLVEKLLLhrwAKEQtsLYKRSL 153  Eremothecium ...
XP_003647570   92 SQANPRMLANIINYFp---rSLEDD-------SNVIAligaiRGVDFE------FSASLVEKLLThrwTKEQtsLYKRNL 155 
XP_002552039  117 GAKTARLLSSLINSF-----PEKSE--------KLVEimvslDFMESELCTYI-TDDKLLERTAKf-tVKERalFRKSLL 181 
EMR68761      251 RYATnqlYRQANYNLLREESEGYSKLAAELYR-TPCNrefDf-pLVMAAWERVKGLIGTFDLDVGRVLDIVIDVFSATML 328 
XP_022466264  175 KKNK---FELQKFNLLSESPVGFAQLTTLFVSfYSDN---SrlaKLDYYTNEMYFIMGKFSLELIKSMDIFLGISAKYLY 248 
XP_001646433  154 KKYK---YEVKKHNLFFECSVGYSQLVSLLLMaYNDN---NnlqKITFYIDEVYHISGKYSLDSMRVLDTILRVSSNFIT 227 
XP_003687075  155 KKTK---FELKKYNLLFECSSGYGNLIALLYMaFHDI---DkidKIDFYSHELSHVMGKFSLDSMRSLDLILRISSEFVT 228 
CCE90618      161 KRSK---YELKKFNLLAECPSGYSQLVMLLSSaFNDL---DntqKVAFYAKQMSHIIGKYSLDSMRSLDIILDVSSEYIT 234 
6_pfamImport  135 KKSK---YELKKYNLLAENSVGYAQLVTLLILaYHDP---DnssKVSAYLKEIYHIMGKYSLDSIRALDVILDVSSQFIT 208 
P53552        163 KKSK---YELKKYNLLVENSVGYGQLVALLILaYYDP---DnfsKVSAYLKEIYHIMGKYSLDSIRTLDVILNVSSQFIT 236  Saccharomyces...
Q754L4        154 ISEK---YHLKKYNLLFESPLGFSQICMLLHVaYADK---DrfqSADYYWRQIQFVAGKYTLDPIRVLDVILRVSSVHVH 227  Eremothecium ...
XP_003647570  156 ISEK---YHLKKYNLLFECAPGFSQICSLLHVaYSDK---DrfqSLKYYWNQMQFIAGKYTLDPIRVLDVVLRISSIYIH 229 
XP_002552039  182 DTR----YIIQKYNLLSEHPIGFSELITLLVIaYSDP---TsaeRARSYWQEACSIVGKYSLDPLRALDVILMVSSRYIT 254 
EMR68761      329 RNIRFYTRFLRISSWW----PRyqidhaekvfigglpkwallenedvsdeeleaqlaeechqrditfwdrvreahldaff 404 
XP_022466264  249 TNYSDMVAFLKATNFVrlggPD---------------------------------------------------------- 270 
XP_001646433  228 DGYTFLVEFLKASDFW----PK---------------------------------------------------------- 245 
XP_003687075  229 EDYNFILKLLQATDFW----PN---------------------------------------------------------- 246 
CCE90618      235 DHYTFFIQLLKNSDFW----PK---------------------------------------------------------- 252 
6_pfamImport  209 EDYQFLTSFLQESDFW----PS---------------------------------------------------------- 226 
P53552        237 EGYKFFIALLRKSDSW----PS---------------------------------------------------------- 254  Saccharomyces...
Q754L4        228 HHHEFLVLLLQRSDYW----PL---------------------------------------------------------- 245  Eremothecium ...
XP_003647570  230 NHYDFLLDLLKVSDYW----PH---------------------------------------------------------- 247 
XP_002552039  255 KGYPFLLEFLKESDYW----PA---------------------------------------------------------- 272 
EMR68761      405 elggrrveeadlqrftdassntktysDLNLEWIKTTKTLPPSGNRVAAQLLGFKFR-FYTSVardKSETLPANLYYLAAY 483 
XP_022466264  271 --------------------------TK---------------NLALTNLLVVNLN-----E---YDGELRESFWQICTI 301 
XP_001646433  246 --------------------------NNSLADNSNYVGLKKGGNLIASNIIQFYLN----SD---LQDEEYLKYVDMCCI 292 
XP_003687075  247 --------------------------EK-LSNSNISNSDHLSENVIVSNVIAFTINsFAMDD---PTKLDSIRYIDMCCI 296 
CCE90618      253 --------------------------NN-EADSISLEGLNHGGSMVASNVISFRIS-QKGPK---IDM----KYLDMVCI 297 
6_pfamImport  227 --------------------------NH-VADSSEYSALNEGGSMIAANIISFNLS-QCKEQ---TDKENYKRYMDMCCI 275 
P53552        255 --------------------------SH-VANNSNYSSLNEGGNMIAANIISFNLS-QYNEE---VDKENYERYMDMCCI 303  Saccharomyces...
Q754L4        246 ----------------------------QRSDPFAWETLNVGGSAVAAQLIAHKLK----------NEKFDHRYMDMVCV 287  Eremothecium ...
XP_003647570  248 ----------------------------EISDPFDWNKLNYGGNVVASRLIAYKLS----------NEKFDHKYMDMVCI 289 
XP_002552039  273 ----------------------------TEANHTSFDNLHIGGNMTASQLLSMHLN----------DTKVDVTFYDMTCL 314 
EMR68761      484 LIKIGFISLPDLYPHLWPADEQMDALKERRMEELAEK--ErndrqgGVPNALLRAGALPddDPIRP----SAkpREpi-- 555 
XP_022466264  302 LVQAGIVDADLVWHNLSPATESLEESLAKVETYLEKEstK------GTDNPLAMAAALSaeDEDk--------dANmdaa 367 
XP_001646433  293 LIINGFVNFSSIWENLKPSDSSLEEYFTEFDKELEEEslK------GSSNPLALAAALTadDDDDDdsnsFNkdSNnkmk 366 
XP_003687075  297 LIKSKFVHFSHIWIKLSPTSKEFVKQLQEYQDKLEKEsmQ------GVSNPLAMAAALSleDDEDEeangRKvdDNkltq 370 
CCE90618      298 LIKNGFVNVLSIWQNIGPDCKSLGEFFKKFENELEEEsmK------GVANPLAMAAALSfdEDDRDtn----iqKHsedk 367 
6_pfamImport  276 LIKIGFINFYSIWDNVKPEMESLQKYTQDLETELEAEstK------GIENPLAMAAALSa-ENENDed-avVvnVDdndk 347 
P53552        304 LLKNGFVNFYSIWDNVKPEMEFLQEYIQNLETELEEEstK------GVENPLAMAAALSt-ENETDednaLVvnDDvnmk 376  Saccharomyces...
Q754L4        288 LIREGFVSYLSIFDSLGPDDETLAKYVDEYYADLCKQsqE------GSLNPLAMAAALPdeDDGPPgatds--------- 352  Eremothecium ...
XP_003647570  290 LIKEGFISYISIFEALRPDEETVQTYVEEYYADLEKQssE------GVLNPLAMAAALPdeDETSApaan---------- 353 
XP_002552039  315 LVRANFVSFSSIFENLGPNEDQIQKFADQYFSDMEEDsmK------GVLNPLAMAAALVddSEESEnp------------ 376 
EMR68761      556 ----iAAKSEASktDSNAANAED-ETSLPEPK---EaHKADLVTHLLVVGAIPEALFILGRFPWLPEAYPdEIYPAINRI 627 
XP_022466264  368 --nkeTAKDTGNdaETGTLENQEsASMEtl----tSsGKIQFIRYLLIFGCWDDVYKLLRTYPKILYLDN-DIPRLIARL 440 
XP_001646433  367 asqvkPNAEDNEvdDSTNQIDNKgVDEEENTKsikK--KLFLLQRLLAHGCTVPVFYILERYPKFMFIED-TTAKLVTRV 443 
XP_003687075  371 --kspNSSEGKKtsDDHESKAQNtTNNNNIdi--tGsVHILFLERLLSIGCYDAVVQIFREHPSLMSVNK-LIPKLFARL 445 
CCE90618      368 --eskIKGRNE---SDAKMERREtQSSE--IDdilQsGKLQLLQRLLVHGCLTASFYLLRRHPTFVHIDD-SIPLAVVRA 439 
6_pfamImport  348 --dviPVTTN----GEANLKDKQkIFQEdt----lSyGKIKLLERLLVHGCVVPVMHVLKEYPKLLYVSQ-SIPKYFGRV 416 
P53552        377 --dkiSEETNADieSKGKQKTQQdi---------lLfGKIKLLERLLIHGCVIPVIHVLKQYPKVLYVSE-SLSRYLGRV 444  Saccharomyces...
Q754L4        353 -kgedKAAQAALseQKERDEQKQeRERKNRQYkvkRtGKWRLVTSCLNHGLLIPALYSIRTNEKTALSID-ILVESVLRL 430  Eremothecium ...
XP_003647570  354 -geqkSDGQVNVkkEKERQEQREeKERKNRHYrvkRtGKWRLVTSCLNHGLLFPALYSIKKNEKVALSID-ALVEACIRI 431 
XP_002552039  377 ---apADSQKESdqEEELSDEEKqARKMREQEeilGsGKMFFMQRLLAHGIFTPFFSAFGRYQRFLLTSP-ELLKLYLKL 452 
EMR68761      628 ILHSISKVYKDTL--PTEVRPttgllarpevapdqSGVSKGN-VRLVDGT----PAKILKWPHADGia----kGILYRFY 696 
XP_022466264  441 LEVMITPLYEKTPffL---GT--------------NGIRENLmITKSENGllshKPRLYTTSQTGDpfagtelNVEMQFF 503 
XP_001646433  444 FSYKLDDFYHEFCipH----L--------------HDISDPLdIPCVENGnlsvKKQLMIERETHNpfvgislQTKFKFY 505 
XP_003687075  446 FEYRINSLYENTClsQ----I--------------ENLTGALkDTVNESDlishRSKLINYELTHDpyettflNTKFKFF 507 
CCE90618      440 FEYITELIYHSTVfsP----Q--------------EVLQSSRlVTLNENGilshKPRLIEERKTHHpsapfelGTRAVFY 501 
6_pfamImport  417 FEHLLDPLYTSMTscC---ES--------------NGMTSALmITRIDNGilahKPRLIHQYKTHDpfeslelNTKYFFY 479 
P53552        445 FEYLLNPLYTSMTssG---ES--------------KDMATALmITRIDNGilahKPRLIHKYKTHEpfeslelNSSYVFY 507  Saccharomyces...
Q754L4        431 FEHMIRPLHEKAInaPSYQPT------------------PRVkMKMTHSGlpskQGRLIYECLSPNvkekyllNTRYVFY 492  Eremothecium ...
XP_003647570  432 FDYMIQPLYEQAInaPKCNAV------------------SRVtMKMSNSGlpskEPRLIHEYVSPNvserflfNVKYSFY 493 
XP_002552039  453 FDHIITPIYETTAffNSAKQS---------------------------------TAGKQNFSATHTalppfdkKNSSEFY 499 
EMR68761      697 LDEWADNVPICQTADDVFTLCSTFLNVCGVNIGRDPTLVKKLAVIGVKSY-LQDQSPE---NASRWQDILRRVLVPSLSL 772 
XP_022466264  504 FKEWSEGIPKCGTVDALFERSHEYLTVAGPKVAQSPSFVSKLCRIGIHDIeTSQLKEE---STDRWIDYVRKFLLPMTST 580 
XP_001646433  506 YSDWSKEFTKIDSIDTLISKSHKYFHYLGPYLAKEPQLISKICRIGIKSIqNNSKVEEt-nSVDIWVDYFRKFILPCIPL 584 
XP_003687075  508 YEDWKSELAIIESIEKLFEESHSFFYTIGPYLSHATILLSKLVRLGISDIkDEKDDELrvsKIDKWIDYTRKFIMPTLPL 587 
CCE90618      502 YPEWTSELSLVNSVEDLIKTSHEYFSIIGVRLAVCPKLISKLCRIAKSDIsGGNGS-----T-ETWVDYVRKFIFPSIAS 575 
6_pfamImport  480 YSEWDCAFTPFTSVDDLFENSHAYLSIIGPYLAKVPMLLSKISRIGVADIqKKQSSESqqdTVDKWIDYVRKFIFPATPL 559 
P53552        508 YSEWNSNLTPFASVNDLFENSHIYLSIIGPYLGRIPTLLSKISRIGVADIqKNHGSESlhvTIDKWIDYVRKFIFPATSL 587  Saccharomyces...
Q754L4        493 YSCWADRLPVIGDVDGLFYHSHEILGLVGSKLSASPTLISMLSSIGVHDIlSSENSEL---VTEKWINYFRKFIFPALGG 569  Eremothecium ...
XP_003647570  494 YTEWTDKLPVLHNIEDLFRYSHQILGLLGPRLSVSSSVITKLNSIAVHDIeSSNNSED---TIEMWINYFRKFIFPAIAA 570 
XP_002552039  500 FSGRMQELPQVNNVEQLIKVSHEWLSILGPHVAYDPVIVSKLCRIGLKDIeRSSRNPD---TLSIWLDFTRKFIFVSLPL 576 
EMR68761      773 GTSNVDAVTAVWELLKHYPTHVRYNIYAECYEGQISRLPALAKAFKIARLDTLATLKRLSLTNIPSSAK 841 
XP_022466264  581 EFSNSIVTSELFSLMTLFPVERRYFMYNEMITKLSQDNILVKIGFNKAARDAKSILKSLSTDTISKESR 649 
XP_001646433  585 LEVNPTITTEIYELMKLFSFEKRYFMFNEMISKLSQDNLLIKLGFTKAEKEARSTLKSLSTDNIEfeai 653 
XP_003687075  588 LENCPSVATNIYELLSMFSFEKRYFLYNEVLSKLSKDDVNVKIGFNRAAREAKRLLKVLNTDNIEQEAR 656 
CCE90618      576 LDLNPTVTNEIYGLMKLFPFERRYFMYNEMITKLSQDILPIKVGFNKTEREAKSMLKALSIDSIDEQSR 644 
6_pfamImport  560 LQNNPIATSEVYELMKLFPFEKRYFIYNEMMTKLSLENLPIKVSFNKAEREAKSILKALSIDTIAKESR 628 
P53552        588 LQNNPIATSEVYELMKFFPFEKRYFIYNEMMTKLSQDILPLKVSFNKAEREAKSILKALSIDTIAKESR 656  Saccharomyces cerevisiae...
Q754L4        570 LEEDFIANINAYNLLKLFPFEKRYFLYHEMYSKISDSDIFVRLTFNKVQRKVRGLLKSLSIDHIDDkvn 638  Eremothecium gossypii
XP_003647570  571 IEDDFVPNLSAYELMKRFPFEKRYFLYNEMYTKTSNDNVFVRLAFNKVGKRIKTLLKSLSIDDIAdkvn 639 
XP_002552039  577 LTDNLVVINEVFVLLQSFDFEKRYFLYNEMISKTSQDNVFVKAKWNESSREAKSALKSLSNDNIGEKGR 645 
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