3BPT,6XYW,4J2U


Conserved Protein Domain Family
ECH_2

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pfam16113: ECH_2 (This model is not part of the current CDD release)
Enoyl-CoA hydratase/isomerase
This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.
Statistics
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PSSM-Id: 522187
Aligned: 223 rows
Threshold Bit Score: 256.631
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3BPT_A         16 TGVITLNRPKFLNALTLNXIRQIYPQLKKWEQDPETFLIII-KGAGGKAFCAGGDIRVISEAEKAKQKIap-vFFREEYX 93   human
XP_002515579   58 VAVITLDRPKALNAMNLDMDVKYKSFLDEWESDPRVKCVLV-EGSSPRAFCAGGDVKAITSKNQLSHMIe---VFTAEYS 133 
XP_002672081  936 TRCLQINRPRESNRITSEVARDLLHQFKVMDTNPIINLITL-SGIGNGFLSAGYDFRELQNLMDKGDYEtvysLVRDTHK 1014
XP_020428888  192 YARAFLNNRKTLNAIDISTIDLLEEFVKDKIKDDTITSFSIhTSTPGVIHSAGTDFVTLFEKRNTELPEq---YFRKLYK 268 
XP_003290840  166 YKRAMLNNREKLNVLDLSTLTSIEHFIKTQVANDIVGSYSIhTTTPGAIQSSGIDFVNLYESNQNRKYIs--dYFKKISK 243 
XP_004350242  178 FSRALLNDRKTLNSLSDTTLRLIDEYLKEVIINERISCFSLhTSTPGLIQSAGTDFVAMFEKRNTEYPQe---YLKKLYK 254 
Q8I523        190 ICEIILNRPEKLNAINKDMINALLNIIKSLDNDERCFMVII-RSTNSNCFSSGSDVKYVVENKEQgi-----qHLKQLYL 263  Plasmodium fa...
XP_002680102   73 CLCITLNRPKSFNALSLSMIRSLRRILEQALSDTKVHFVIL-QSASDKAFCAGGDIKDLRRGFEYaq-----qFFTEEFS 146 
XP_004351918   53 CLKIILNREKALNSLTLEMINHLLNLLKKYENDKRVTFVLV-VGAGDRAYCSGGDLLEFSSSVEM-Sh----rLSNTEYK 126 
Q55GN0         49 CKRIILNRSEALNSLTMEMLKFLSEKLKEFNNDDNCKFVII-NSSTEKSFCSGGDIKEFSQLSRSSAGVn--eFIRVEYA 125  Dictyostelium...
3BPT_A         94 LNNAVGSCQK--PYVALIHGITXGGGVGLSVHGQFRVATEKC-LFAXPETAIGLFPDVGGGYFLPR-L-QG-KLGYFLAL 167  human
XP_002515579  134 LICKISDYKK--PYISFMDGITMGFGLGLSGHGRYRVVTERT-VLAMPENGIGLFPDVGFSYIAAHsPgEG-SVGAYLGL 209 
XP_002672081 1015 LAYYAANCET--PTMSVINGLMLGPGTSLGTSANYVIATPGS-LFSAADSAYGYFPDCGVTMLLSRvNqKHeGLGTFLGL 1091
XP_020428888  269 FFYLLAASPK--PHVSILDGLAVGSGAAFTANSAVRVATENS-IFSVPDCAIGFFPDAGMARFLGK-L-PG-SLGRYLAM 342 
XP_003290840  244 VFYLMSVAPK--PQLSIIDGLTVGAGLGFTANSGFRVGSENS-IVTISDCALGFFPNAGNVRLLNR-L-PD-GIGLYLAL 317 
XP_004350242  255 AMYLLAITPK--PQINILDGLAVGSGAALTANSGIRVVTENA-VMSFPEAALGYFPDCGSMRLLAR-M-DG-FLGKYLAL 328 
Q8I523        264 YINYISQMKK--NLLCIWNGYVMGGGLGISIYSKYKVINKNA-IFAMPENKIGFFPDIGCCYFFRK-Y-FGrNIGLHLGL 338  Plasmodium fa...
XP_002680102  147 LNYYIHEFCKvkPIVSMLNGITMGGGVGISIYTNLRVANRKRfQFAMPEVFIGIYPDIGASFFLTR-AcSSiGIARYIGL 225 
XP_004351918  127 LDYLIHTYSK--PYVSIVNGIVMGGGVGISIHGSHCIVTERA-LWAMPECFIGYFPDVGTNYQMSR---LG-AIGLYLDL 199 
Q55GN0        126 MDHLIHTFNK--PILSFVNGIVMGGGVGLSIHSSHRIIGDNV-QWAMPENRIGYFPDVGTSYFLSR---LG-SIGLYLAM 198  Dictyostelium...
3BPT_A        168 TGFRLKG-RDVYRAGIATHFVDSEKL--AXLE----EDLLALKSpS--KENIASVLENYHTESKIdr---dkS-FIL--- 231  human
XP_002515579  210 TGKRISTpSDALFVGLGTHFVPSGNL--GSVK----EALFSMTFsQdpNDDIKALLAKYSNEPES-------E-AEL--- 272 
XP_002672081 1092 TGAQVKS-SDLVNCGIATSFGMESMS--QYIA----ERLLEVQTg----ANQDDIHNCIVESTESdvp-alsFaFEL--- 1156
XP_020428888  343 TGGRLRG-SDIMESGIGNFYIRTNQI--QYIE----EWLGRVPIn-----RSDRLFANLDIHTENwdn-kqsI-QKThye 408 
XP_003290840  318 TGRRIRG-TELHEAGITDFFVLTEDI--QGFD----RNLSHCFPk-----NHNRLFESIVLSTTEprs-ylnG-KKThlt 383 
XP_004350242  329 TGRRLRA-GELIQTGVGNFYMRTAHI--PLIE----DSLCQLPPn-----RPDRMFLHLDTHSDSfdd---lvsQPThyt 393 
Q8I523        339 TSLRLNE-VDLINFNVCNNYIENVDTfmDNL-----NNIKATNQe-----DFNKKLNNLLTNKYVskmsynkSnNPVltd 407  Plasmodium fa...
XP_002680102  226 TGAKLGA-TDSLFSKLVTNVIDNEEVf-YELRrdlfEKFIPTENe----SNLEKQLEKFIQIYEKkgn-tvlN-STLgqv 297 
XP_004351918  200 TGTRIKY-RDLVGLGIASHHVPSDML--DRLV----RDLTENTVdT--TRQLDFIINLYRKQVGYrlh-niePsTMVewl 269 
Q55GN0        199 VGVKINS-KDLINVKLATHYIPNELF--ERTL----EELCNDDDiEg-YRQIEFILNKYRKTLYPdk------------e 258  Dictyostelium...
3BPT_A        232 Eeh----xdKINSCFSAN--T-VEEIIENLQ-----------Qdg--------ssFALEQL-KVIN-KXSPTSLKITLRQ 283  human
XP_002515579  273 Kll----lpQIISTFSAS--NsVKEITEELKkh--------qQsadt----kvaeWASDAL-QGLG-KGAPFSLCLTQKY 332 
XP_002672081 1157 Y--------KIKEHF-SNkkS-VEEIIQSLKntitdstktkpEr----------dWAANIL-ENMN-QLSPLSLKVTFRA 1214
XP_020428888  409 Qyk-----eAIDRCF--SkaS-VEEIMDALRae--------tQhp---------aWAKRCL-DNMN-RMSPLSLKLTLVF 461 
XP_003290840  384 Thq-----dAIKRCF-DNktT-IEEVLQALEne--------tEfa---------eWAERCI-RNIR-RSSPISIKLTMRL 437 
XP_004350242  394 Tyr-----eAIDRCF--SkdT-VEEIIEALHke--------rQhs---------dWAKRCI-QNMN-KSSPLGLKLTNAL 446 
Q8I523        408 Eli-----nNINTYY-SSanT-LEDLITKLKkdn-------------------ndFCKKLL-SDIY-SNCYFSCMFWFSY 459  Plasmodium fa...
XP_002680102  298 d----rfrrVIDYCF-GEaqS-VKEIISNLKwyk-----ehhPcrsq----sdneFIDSIL-ELFSkRASPTSLVVTFEA 361 
XP_004351918  270 Vqn-----qCLERCF-GNhiKsVQEVLDNLEn----------EiknnngdekvrkWAEQTL-TKIT-GSRPLSICACFKA 331 
Q55GN0        259 SshlvlyqsIINRCFNNKefKsVKEILNQLKveie----nvdNknnk----deieWASKTLsILLD-QLCPTSVCVSFEI 329  Dictyostelium...
3BPT_A        284 LXEGSSKt---------LQEVLTXEYRLSQACXr-GHDFHEGVRAVLIDKDQSPkWKPADLKEVTE-EDLNNHF 346  human
XP_002515579  333 FSKVASAygkpnselstLNGVMKTEYRIALRSSl-RNDFAEGVRAVLVDKDQKPkWNPPSLEDIDQ-NEVESLF 404 
XP_002672081 1215 IQECDQGl--------gLDETYQRDYRIASRLIk-SKDFKQGVNSVLTGIE--PvWEFESVEKVPD-SVVDSLF 1276
XP_020428888  462 MDYALQPnplld-qplsLKEHFEMEYRITSSLLeeGSDFWEGIRANLVYK-RAPqWKYKTLADVTD-EVIEHHL 532 
XP_003290840  438 FNETPTDg--------kGKDYYERDYNISMALTrdHSDLWEGIQSLLIQN-REPmWSYKRVEDVPD-SLIDEII 501 
XP_004350242  447 YRHVAEAket-----isLRDLLSLEYKIANCLFeeGSDLWEGVRSNLVYG-RAPnYRYKTLSDVTD-SVIEDHF 513 
Q8I523        460 YLYNYEKs---------LEEVLNNDFKITQYFLfhKNSFERGVTEVLVKKNKNFqWSKDEETNNADfEDIDDIL 524  Plasmodium falcipar...
XP_002680102  362 LERGRKAs--------sLKQVLDLDKLLCTKLVg-QHDFVEGVRAVLVDKDQKPkFKPATLDELNVhQVIKEIF 426 
XP_004351918  332 FRDSLNLs---------IDDVLKMDNRVGTHLTqiEEDGREGIKAALFDKTYKPqWIPPTIQQVDP-NIVDSLF 395 
Q55GN0        330 IKRALQMn---------IDQIFQMEVRVGTRLGn-RQDLTQGVFKTLIDKTHKPiYSPSSIYDINQ-SFIDSFF 392  Dictyostelium disco...
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