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Domain of unknown function (DUF4825) This domain forms the N-terminal, extracellular domain of some homologs of Staph BlaR1 proteases, where it replaces the penicillin-binding domain of BlaR1. It is also found in many uncharacterised proteins in a broad range of bacteria. Its association with BlaR1 homologues suggests it may be involved in substrate-, possibly antibiotic-binding, but this prediction has not been verified experimentally. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",