Conserved Protein Domain Family
RMI1_C
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pfam16099: RMI1_C (This model is not part of the current CDD release)
Recq-mediated genome instability protein 1, C-terminal OB-fold
RMI1_C is a C-terminal oligo-nucleotide binding domain of Recq-mediated genome instability proteins. This domain interacts with RMI2-OB folds to make up the RMI core complex. The RMI core interface is crucial for BLM, Bloom syndrome, dissolvasome assembly and may have additional cellular roles as a docking hub for other proteins.
Links
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Statistics
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PSSM-Id: 522183
Aligned: 20 rows
Threshold Bit Score: 147.031
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_012703032 613 EKPYTYICSMFSdwgtQQDTKAYIqGKIKGLITSVKRFQYRRRT----T-YELYVYIDDGSFISEAFVDHNIVENMLGLS 687
EFX85674     432 ERPFTYLSSHLRkr-aSNVKCQPEsICVKGFVSTITGKLVATKSetgvSqWQLSAVINDGSDGLKVDFSPQVLEELIGHS 510
XP_032519096 307 ASPFVYIKQIIDl---NQSDRINKvFKVKAQILHLLKRPSFTKD----K-WMVECRITDGTGCLNVEVNSCLFSTIISHT 378
XP_002424943 400 NKPFVYLKHIKQ----IKYLNHPCiFTIKAMILTLKKKITLEND----K-FSLQAIITDGSECLDVTFTSNILENILNYS 470
XP_009112086 468 ETPFTYLAEMSQnwavMKDTMPFVqGRIKCFLTGVKRFQFKQQS----T-FELICYVDDGSLICEILLHNDVVQRRIGHS 542
XP_024374553 534 EEPFTYLAFLKErlsaGPGYNAAV-GKIKCVLTGVKDFKFKDSE----E-FALIVHVDDGSLVTEALIHHEVVQKMVGFS 607
XP_002112356 364 ENPILYLIDIENdl-rKNSVTFPFtFHIKAYFSTLLSPLNSRNK------WHVKARINDGTSYLDVDVSDQVLSEIIGFS 436
XP_048577339 527 SLPFTYLKTVEQh----lPFQEDItIRIKAYVSTLVNHSQTPGT----G-WCVTVKVNDGTAAMDMDLGAEVLTELLQMP 597
3_pfamImport   1 SPPFTYLCLLENl--mSKPLLHTMeIHVKAFIVTLLGKLTSSNG----V-WSVSATISDGTGYLDVELSNEVLTGLLGFS 73 
1_pfamImport   1 SPPFTYLCLLEEm--tSKPQPHTReIRVKAFIVTLVGKLSGNNG----L-WRIRATISDGTGYLDVELSDGVLTGLLGFS 73 

XP_012703032 688 PGev---tAALAGEFE-FASASEVK----ETLRGFQSFLINFEGMMLIEFNKD------------------------SSI 735
EFX85674     511 PAal---kSMMAVVGD-DNKRRGL-----EVLEEAKQKLIRLNCLLHIRWPAApddpdcasnvmssrsrqvgipatsHKL 581
XP_032519096 379 PQema--elSLQRQRD-PATKDRIDrdfvKYLSEAKRKLDSEYSIMELNMSPT--------------------------- 428
XP_002424943 471 PCel---qAMMKEKEQnSAIGCKIK----EIFKKAQEKFISLNCLMKIKFFPN------------------------ENP 519
XP_009112086 543 SMev---tAALSSSAP-TKENAMMK----EKLKGFQLFLADFEGMMVVEMNRT------------------------SQY 590
XP_024374553 608 PKev---nRALASS-N-PQDVREMK----SNMKRFQAFLKKFEGLAYVQYKQI------------------------LDL 654
XP_002112356 437 AEk----fNKLKLVSD-QSERKLMQ----QGLKNCQQTLSQINCVMEIILNRS-------------------------AV 482
XP_048577339 598 VEsfqnlmQEAKKSPD-TELRRSLQ----QHTEQFQRNLSMVTCLMDVSFVCT------------------------RPR 648
3_pfamImport  74 VA------EKGALKRD-PSRRGELD----AGMRRCQEELVDMCCIMTVIVQPE------------------------GRK 118
1_pfamImport  74 VA------GKASLKRD-PARRGELD----GGMRRCQEELVDMCCVMTIAFEPD------------------------GGR 118

XP_012703032 736 PIIRELdEGCSSSNAWLLLrRL 757
EFX85674     582 PVVYRL-EDIERRHLEMLq-LL 601
XP_032519096 429 PVITQF-IPFTEQHVMLLQkRL 449
XP_002424943 520 PIVLHL-EDLTPSHLNQLKnRL 540
XP_009112086 591 PVAIEMnQGCSSTDARLLFeRI 612
XP_024374553 655 PVISHMeEGVKEGDLTALLaRV 676
XP_002112356 483 PLLIQL-KQSTIYNMKNLItRV 503
XP_048577339 649 PVLIRL-RQPSRDDVKMLMsRI 669
3_pfamImport 119 AVVTKV-DPVSEKILQELEqRI 139
1_pfamImport 119 AVVTRA-EPVSEKVFQELQqRL 139
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