Conserved Protein Domain Family
PAC4

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pfam16093: PAC4 (This model is not part of the current CDD release)
Proteasome assembly chaperone 4
PAC4 or proteasome assembly chaperone 4 protein promotes assembly of the 20S proteasome. It interacts with PSMG3. It associates with alpha subunits of the 20S proteasome. At the very C-terminal is a crucial HbYX or hydrophobic-tyrosine-X sequence motif that, in proteasome activators, opens the 20S proteasome entry pore.
Statistics
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PSSM-Id: 522179
Aligned: 105 rows
Threshold Bit Score: 31.3836
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002184110  50 ITFSkkAATIwFGWGSLQSSKTsgpggnagygatpvgakslcvgtapnlsmGPLVVAMPRPRYkg-sLSISaepsTSKLI 128
XP_002175316  33 VVFLypSDAV-FIWASNKASAPf----------------------------GSMSLAMPSLNPar-rGEIV----SSTLT 78 
Q9P7J0        23 VIKLnpSSSI-FVWGSNVSTCPa----------------------------GDLALSMPGk------SDVV----TTKLT 63  Schizosaccharom...
XP_007875087  27 LILL--RPSTsLIFILNFLEKPl---------------------------fGSLSLSIWTKDKgassTSLR----TTNIH 73 
XP_012652696  20 FTLL--QEQI-ILVVTDRELNL-----------------------------TNIHMAMQTKYEdf--------ptATCIK 59 
P0C8Z5        35 FYIFksQDSPiFIWVSDSPTF------------------------------STLSVSMKIPIE----KSPV----TSHLL 76  Dictyostelium d...
XP_003284795  35 FYIFqnPNSPlFIWVSDQPNL------------------------------NTLSVSMKIPME----KLPV----TSELI 76 
Q8IBL7        49 IINF--KETM-FISVTDDNNQM-----------------------------NDLQVSYPIKYEda--------dnTICLV 88  Plasmodium falc...
XP_001612789  52 ILDF--KDTM-FISVTDERNQL-----------------------------TDLQASYPLKYAda--------dnTACLV 91  malaria parasit...
XP_001913774  19 MIIL--EKEI-IVVIQYKNSNEl----------------------------NGLSLSQKTVEQlp---------sTTQLY 58  Entamoeba histo...
XP_002184110 129 GYDDEGDemVARQMSSRLSQRLGIAIFVSCSF 160
XP_002175316  79 GIGSVDE--SSNRLSRILSARFRRQVFATTEL 108
Q9P7J0        64 GAGSIDD--LSTQMSRILSKKFQAQVYTSINL 93  Schizosaccharomyces pombe 972h-
XP_007875087  74 ----S----ISQQLSCLLAKRFARQCYVATpl 97 
XP_012652696  60 DDQGRQDeqYIQTLARSLCKKNKINVCLSYNL 91 
P0C8Z5        77 ESNSITSndSSNSLSQRIVIKFKVQTFLSYSI 108 Dictyostelium discoideum
XP_003284795  77 DSSFGISkdSSMSLAQRIVIKFKVQTFLSINI 108
Q8IBL7        89 GEPHS----YGNDIARLLGMKFKMPFFVSVNV 116 Plasmodium falciparum 3D7
XP_001612789  92 GEPHS----HGNDVARLLGIKFKIPFYVSVNV 119 malaria parasite P. vivax
XP_001913774  59 GDV-LDS--ESQSLSQLFSMKLKKRVTVSCNV 87  Entamoeba histolytica HM-1:IMSS
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