Phage_holin_8_1 is a family of two transmembrane mycobacteriophage holins, small hydrophobic proteins that effect lysis of host mycobacterial cells in conjunction with a mycobacteria-specific lysin, lysB. The product of lysB gene targets the mycobacteria outer membrane, the last barrier to bacteriophage release.
Jiyao W et al.(2023). "The conserved domain database in 2023.",