Conserved Protein Domain Family
Phage_holin_2_3
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pfam16080: Phage_holin_2_3 
Bacteriophage holin family HP1
Phage_holin_2_3 is a family of small hydrophobic phage proteins called holins with one transmembrane domain. Holins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion 1,2].
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Statistics
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PSSM-Id: 495571
Aligned: 7 rows
Threshold Bit Score: 74.8246
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0WF59        45 EKYTSGSSYGWGAFTVMLGSLSLNEWAIVVGIACTVGTFTINWHYKRKEFQLREKA 100 Yersinia pestis
3_pfamImport   1 DKYSSPTAYAWGLITSAFGILSLDQWAIVAGIICTVGTFLVNWYYKRKEFQLKAGE 56 
Q7N1Q6         4 DKYTSPTAYTWGTFTAMLGALSLNDWAIIIGIICTVGTFGVNWYYKHREL---SRN 56  Photorhabdus laumondii subsp. laumondii
2_pfamImport   1 DKYSGPAAYTWGLITSVLGVLSLDQWAVLIGIVCTIGTFFINWYYRRKEFQIKAGD 56 
1_pfamImport   1 EKYATPTAYLSSLMATVLGFFTLEQWVAVTGIVCTIGTFLINVYYRKKEYKLKARH 56 
P51727         3 SKIDSAIPFIGSLTALISGY-SLHEWASLFGILFGAVSVWIAYRKYKEDVQARKDE 57  Haemophilus phage HP1c1
Q2S7H4         3 DKAASAAAYASSAVATLFGL-SLSQVVALGGLLIAAATFVMNWYYKQKHLDLAREQ 57  Hahella chejuensis KCTC 2396
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