Conserved Protein Domain Family
Phage_holin_5_2
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pfam16079: Phage_holin_5_2 
Phage holin family Hol44, in holin superfamily V
Phage_holin_V_2 is a family of small hydrophobic proteins with three transmembrane domains of the Hol44 family. These proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion. Full activity of the endolysin Lys44 from oenophage fOg44 requires sudden ion-nonspecific dissipation of the proton motive force, undertaken by the fOg44 holin during phage-infection.
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Statistics
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PSSM-Id: 495570
Aligned: 39 rows
Threshold Bit Score: 45.3123
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CDA61341      22 LVPCLYALGSIIKRSIRIDD---TLIPGVLCVVGIFLSalvsvasceptnwiqwvILVAV------SIGQGYVLAAAAIC 92 
3_pfamImport   1 ITVICYLGGMACKTTEKVKD---EVIPVVCGVTGGILGvagmyli---pefpagdVIN--------AAAIGIVSGLASTG 66 
WP_022346937  11 ITMICYLAGMGMKASEKVKN---EVIPVVCGCAGAALGvagmfvm---pdfpaqdVIN--------AAAVGIASGLAATG 76  Sellimonas inte...
CDB26386      11 ITVIAYAAGQAMKAWG-RGE---RWIPTVCAVLGGILGavglyvm---pgfpandVIT--------AAAIGMVSGLAATG 75 
WP_022410313  12 ITIICYLAAEIVKVTS-LDN---KWIPVICGISGGILGiaalfwm---pdfpvqdVLS--------AAAVGIVSGLAATG 76  Ruminococcus sp.
CDB29296      11 ITVICYLIGQIIKATG-LDN---KWIPCIVGTAGAALGavgmyim---pdfpagdALT--------AVAVGIVSGLAATG 75 
CDB30951      12 ITVICYLMGLIVKNLP-LNN---KWIPSLAGLLGGILGlvgwrfm---pdfpagdVLT--------ALAVGIVSGLAATG 76 
5_pfamImport   1 IVGICLCVGYVIKKW--IKDvdnKYIPTVCALLGVLLA-----------------IWINGwtispaIILSGLFSGLASTG 61 
WP_022072338  14 IIGVCLCIGYILKKW--VKDvdnKYIPTILAVIGVLLN-----------------IWITKdln-veIILSGMLSGLTSTG 73  Intestinibacter...
Q832Y1        12 VVLGCLAVGFVIKNTNILKDkynQFIPLIVFILGILIS-----------------WWIQGkit-peNTIYGALSGLASTG 73  Enterococcus fa...

CDA61341      93 LNQLIKQH 100
3_pfamImport  67 VHQVIKQV 74 
WP_022346937  77 INQAVKQL 84  Sellimonas intestinalis
CDB26386      76 AHQAVKQL 83 
WP_022410313  77 ANQIFKQF 84  Ruminococcus sp.
CDB29296      76 VDQLGKQL 83 
CDB30951      77 VHEAGcql 84 
5_pfamImport  62 LHQLFKQY 69 
WP_022072338  74 LHQVFKSf 81  Intestinibacter bartlettii
Q832Y1        74 LHQSFKNF 81  Enterococcus faecalis
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