8DMT,8DMU


Conserved Protein Domain Family
MavL-like

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pfam16062: MavL-like (This model is not part of the current CDD release)
ADP-ribosylhydrolase MavL-like
This entry represents a class of MavL-like macrodomain enzymes whose representative members show unique selectivity for mono-ADP-ribosylated arginine residue in synthetic substrates, which are distantly related to MavL from Legionella pneumophila. They are (ADP-ribosyl)hydrolases that share a mode of ADP-ribose interaction distinct from previously characterised macrodomains.
Statistics
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PSSM-Id: 522165
Aligned: 19 rows
Threshold Bit Score: 697.514
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8DMT_A        42 NVIKLSAEFPLEFGVNSVKVYRQSPSRL-ARINEEVASAYPLIHERTLGLYLQYLEHKCRWGNAVEKPIYRNLSLCGFVQ 120 fruit fly
1_pfamImport   2 KFQQKSEEFPIAFGTNTCRVKSQPAERH-GQICKQIASAYPVIHERTLALYLDFLQHKKIHGNAIEQRVYQNLSVCGLVQ 80 
3_pfamImport   2 DIINRSKNFSIPFPIESVRLDKLKKHRPiDRLKRNISGTYPIIHERILMLMTHFLLYKREFGSSIEKAFYKDMTIPELID 81 
XP_002075542  68 KFKEVSQNFPIKFGIDTCRVKSQPASRY-EVIQEQIASAYPVIHERTLLLYLNFLEHKKKFGNSKELPIYKDLSLTDFVQ 146
EDW00170      53 KFLTASEKFPIEFGTSSCRVKSQPVERR-QMIRKQIASAYPIIHELTLLLYMNFLEHKQKYGTAQELSVFGNISITEFVQ 131
XP_002009518  65 AFMSISDRFPIPFGTDAGRVKSQPVERR-PHIRQQIASAYPIIHEQVLFLYMNFLEHKLKFGNPKELSVYKNLTLPEFVQ 143
XP_015024182  62 KFMAVSDSFPIEFGTNSSRVKSQPLERR-PFIRQQIASAYPIIHELTLFLYLNFLEHKQKFGNAQELHVYRSLSLVEFVQ 140
XP_975524     34 TVLEKSDNFVLKFPVDSNRCKTLRTNVDnDTLERNINSAYPVLHANILQFYAQFILHKRKNGNTIEKALYNDMNLLQFVD 113
EFA04874      47 QIIEKSSQFPIEFPLESVRCCQLQNHTAvKTLEKNINSAYPVIHEHALYLCAVFLLHQGKYGEKKE--FYKEMSLLQFID 124
XP_001966178  58 KFKGVSENFPHKFPIDSCRVKSQPAARE-DAIRKQIASSYPVIHESTLQLYIKFLKHKLKFGSKTERQLYKNMTLTAFVQ 136
8DMT_A       121 RLLVKRCASFFARNDKYLLVSGESGASGFEAVGTREEKAPLVLANVLSYDDIKLSALLSVSSRTEFVNEGERTNCGHVDL 200 fruit fly
1_pfamImport  81 RLLEKRCVFFLGPSDSYMLMSGDCDYGGFEQIGTLEEKVPLILQNCLSYDEIKLSALLSTSTHTEFINDGARRNFGHVEQ 160
3_pfamImport  82 RLLLKRAVSFMGELDSYLLLSGESGEDGWENVGTLQQRPPLLLENVLSYDEMKLSAFLFVSGPTECINDGSRHNSGVVKD 161
XP_002075542 147 RLLSKRCVYFFGGGDSYLLLDGQKGHGGIEQIGTEDQKPPLILQNVLSYDEIKLAALLYASTHSEFINNGSRSNAGIVQP 226
EDW00170     132 RLLSKRCVYFFDASDSYLLLDGSRGHGGFEQIGSSSERAPLLLRNVLSYDEIKLSALLYVSTHSEFINDGSRFNNGRVEE 211
XP_002009518 144 RLLEKRCVYFVGMLDDFMLLDGTHGYGGFEQTGTMNESAPLELKNVLSYDEIKLSALLYASTHSEFINDGSRTNAGRVEQ 223
XP_015024182 141 RLLSKRCVYFFGSSDSFMLLVGSRGAGGFEQIGTSTERAPLVLENVLGYDEIKLSALLYVSTHSEFINDGSRSNAGKVEL 220
XP_975524    114 RLLSKRAATFIGKQDSYTLLNGKKGRGKWETIGTLAEKKPLVLKDCLSYEEVKLSAFLSVSSFTHFVNLGDRKNMAKYET 193
EFA04874     125 RLLNKRAVVFMGPVDHYLLLNKTSGSGRWETIGTSSETPPLVLENCLSYDEIKLSALLSVSSFSYFINNGDRNNMGYFEE 204
XP_001966178 137 RLVAKRCVWFYGDSDDHCTMEGQQGIGGFEKVGTGEELPGLTLNSVLSYDEIKLAALLYFTTHSEFINNGSKGNAGMVPL 216
8DMT_A       201 NTktLERHGVIVGMIGARLSRRNLMEFQDIVIARQQNTRERGYGmalDEPAt--------------tRDEDYRRLWREFY 266 fruit fly
1_pfamImport 161 DKskIEREGVIIGMVGSRFQRNNKMEWEDILITREQNTPQNGYGl-vDNPT----------------RESDYRRIWRQFY 223
3_pfamImport 162 DD--IEQEAIIIGAIGPRFERTNRMDYEDIVISSTQNSEERGYGe-hVTPTtclhvlrhtytrdaslAKHAWRQLWAELY 238
XP_002075542 227 DKstIETEGVIIGMIGARFERDAVMDCEDVLITPTQNTAAHGYGs-mENGT----------------RATDYRLLWRNFY 289
EDW00170     212 SKskIEIEGVIMGLIGARFERSNVMEWEDIMITPEQNKASRGYGa-sDNESk--------------gRLQDYRRIWRDFY 276
XP_002009518 224 DKsrIETNGIIMGLIGSRFGRSNVMECEDILITREQNTANRGYGy-sGSAEn---------------RVQDYRRLWRQFY 287
XP_015024182 221 DKskIETDGVIMGLIGARFERNNVMECEDILITPEQNTADRGYGt-nGSDN----------------RAQDYRRIWRQFY 283
XP_975524    194 DRsgIQDEGIIMGIIGPRLVKNEVMEYQELVITESQNTKTKGYGq-tETPT--------------------IHHLFAKLY 252
EFA04874     205 NRsrVEENGVIIGVIGPRLEKSRVMEYREVVICKEQNTSCYGYGp-sEEPT--------------------LQQEFLKFY 263
XP_001966178 217 DKstIEPEGVIVGIIGARFERPNVMEFQDIKITKDQNTLARGYG---DQNAt--------------tGQADLRRIWREFY 279
8DMT_A       267 -ATRDLIHGQ--AV---IDNQRFGPSKNKm--dVFDNLVMKRRYAISFDMLLLEAEARAkrVKKLAYIHVVGFGLGVWKA 338 fruit fly
1_pfamImport 224 nEPKDFLYDE--IE---KDYKRFLDIKKNstiyRFDTLVMKKRFAILFDTLLLEAQGRAmrADKSAYIHVVGFGLGVWLI 298
3_pfamImport 239 -QVHSYTYEElsARlagAASDRYVKLPRGg--aWFDNEVYYKRICILAETVLLEAEGRA--RGRSVFLNVVGCGLGVWKI 313
XP_002075542 290 gEPKDFVNDQ--VI---VDGKRFIQLARYe---KFDAVVMHKRYAITFDTLLLEAQARAkkADKPAYIHLVGYGLGVWKI 361
EDW00170     277 mEPMDFCFDDdvVA---SDNKRFINLGRNt---YFDKVVMGKRFAISFDTLLVEAEARAvkAGKPAYVHVVGIGLGVWKA 350
XP_002009518 288 eEPKDFRYND--VQ---ADGKRFIQLKHDi---KFDKQVMGKRFAISFDTLLLEAEARAasAGKPAYIHVVGIGLGVWKV 359
XP_015024182 284 eEPKDYCYND--VQ---ADGKRFIELDSKl---LFDKLLMSKRYAISFDTLLLEAEARAagAGKPAYIHVVGIGLGVWKV 355
XP_975524    253 hE--QCLECKeiLEkkkTNPNRYTTLRNDe---LLDNVLYHKRLVFTMDTLFTEANQRAleKNTTAYIHVVGIGLGVWKK 327
EFA04874     264 gSV-NGTYDKv-LEqigSHPEQYLELGRGk---YFDRLMYEKRLALSIDTLLIEANDRAkqENKMAYVHVVGLGLGVWKI 338
XP_001966178 280 gEPKDFIFDH--FQghlAEPQRFESVNGG----YFDHQVMRKRYRNTFETLLLEAQDRAvrAGKLAYVHVVPIGLGVWKA 353
8DMT_A       339 AEQQERIFMETFEQRMRTLGNR--LNNVGLVHFSWFS--------------ITHCGGLSNGSLIEIPGHPKDGIRVLISK 402 fruit fly
1_pfamImport 299 HDKQEKIFFNSFEERLLALGDQ--LNHVDVVHFSYFT--------------LSKVGKLYDGAFIPFKNHPKRGIKICISK 362
3_pfamImport 314 SPHQTDVYVLTFLERIRAMLDEeaLDHITDVNFAYIRasdnvtalftktneIENSTSTVKSLFVANKKHPKGGVSVQLED 393
XP_002075542 362 SDEQERIFFEAFEERLLALIEMdlLSHIGVVHFSWFH--------------LKKVGGLYNGAVIPQKSH--SGIKIFISV 425
EDW00170     351 APQQEEIFLETFEQRLRALSER--LTHIGVVHFSWFH--------------LDKWGGLYDGASIAEPKHPLGGIKVRIAV 414
XP_002009518 360 SDQQEEIFLATFEQRLRALSAK--LTHIGVVHFSWFH--------------LDKWGGLFDGACIEEPAHPQGGIQVRISV 423
XP_015024182 356 TPHQEEIFFETFEQRLRALSPR--LTHIGVVHFSWFH--------------LDKWGGIFDGACITEPQHPQGGIKVHISV 419
XP_975524    328 HPCQNKLFMDSCGQRILNLGKQ--LHNVSDICFAYIQ--------------HNACLSYKHGDVIPIEGHPLKGIRVHICK 391
EFA04874     339 THQQNKIFMDTFAQRLELLGDE--LKHISDVRFAYIH--------------ETSAGKYSNGDKI-------KGITLHMID 395
XP_001966178 354 ANHQELTFFEAFQESLDGLGER--LHHVGVVHFSWFH--------------LDRVGSLYDGALLRFPQHPQGGIKIKISN 417
8DMT_A       403 RNPARKLSdpehAGMLLVVSYAWDGNALPGNEFWMKMLQSTGDSSTACSTLVAELHNPYINTKfCNGGNLHIASPEhGVL 482 fruit fly
1_pfamImport 363 RNPHENLKd---NTMLSVVSYAWDSNALPGNEFWSGTLHTSSDPAAACSTLITELLNPHINVDyLNGNNLHIASVRyGLI 439
3_pfamImport 394 REPASRLHgr-hRGKLLVLIYPWDGNAHPGNEFWLGSLTGSGDPAAACSTQVAELHNAHVNPR-VAAANTRVAAHA-AVL 470
XP_002075542 426 RNPGDKLM----ENMLPVVTYAWDGNALPGNEFWANMLVGTGDPAAACSTLISELQNPHINLKyMSGSNLHIASLRhGLL 501
EDW00170     415 RNPADKLA----ENMLPIVTYAWDGNALPGNEFWAKSLSGSGDPAAACSTLISELQNAHINKDyMCGNNLHIATLEhGVL 490
XP_002009518 424 RNPADKLK----EPMLPIVTYAWDGNALPGNEFWSKSLDSSSDPAAACSTLIAELLNAHINKDyMSGNNLHIASMQhGVL 499
XP_015024182 420 RNPADKLT----ENMLPIVTYAWDGNALPGNEYWAKVLVGTGDPAAACSTLIAELQNPHINADyMNGNNLHIASMQhGVL 495
XP_975524    392 REPHAKLTgr-dEGKLLVVSYAWDGNALPGNEFWIGKLGSSGDSAAASSTQITELHNPFINPN-VSSGNLRVVKDG-KVV 468
EFA04874     396 KNPQEKLAgd-dEGKLLVVSYPWDGNALPGNEFWMGSLNRSGDTAAASSSQVAELHNWHINAK-ASARNLRIATFK-GLY 472
XP_001966178 418 REAHSKLP----EDMLLVVTYAWDGNALPGNEFWDGVLVSTSDPAAACSTLITELQNPHINREyMNASNLHIASLEhGLV 493
8DMT_A       483 HIAEYAK 489 fruit fly
1_pfamImport 440 HITEYAQ 446
3_pfamImport 471 PLRDCAE 477
XP_002075542 502 HIGEFAQ 508
EDW00170     491 HIADYAE 497
XP_002009518 500 HISDYAE 506
XP_015024182 496 HVADYAK 502
XP_975524    469 GLEEYAA 475
EFA04874     473 TFKEYQE 479
XP_001966178 494 HVGDYAR 500
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