Conserved Protein Domain Family
DUF4776

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pfam16003: DUF4776 
Domain of unknown function (DUF4776)
This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 444 and 485 amino acids in length. There is a conserved TLR sequence motif.
Statistics
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PSSM-Id: 406413
Aligned: 23 rows
Threshold Bit Score: 479.99
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAPP:GF16202-PA  333 PYKPPTLCQLCQSDISWLPKVSACPYCGYKTFEDIPpsEEEYDLtATAQQLLRDCLRKEQCKY--SSSEEDADELPSVRK 410 
XP_002073431         402 CVNTSRLCHVCKEDVSWLPKIAACPHCGYKPVPLFN--EKPYDEnATADDLLHICLEQQQSEGalSSDSVH--------- 470 
XP_002037320         365 HISNTRSCVLCGEDVSWLPKVAACPCCGYKPVPEFK--ERPYDEqATAQQILLDHLENPVENL---SFDMGS-------- 431 
WGS:AAPP:GF16203-PA  460 HISDIRACILCGEDVSWMPKIAACPYCGYKPVPDFK--EKPYDEeATAEKILFDHLDNQ------EDFDMGS-------- 523 
XP_001998885         358 GVKPERSCLMCHADVSWLPQIAACPHCGYKPLPIFT--EKEYDEsATAKDIIVDFFQQKSSES----------------- 418 
XP_002056156         252 GMKRGHECPMCHEDVSWLPKIAACPHCGYKPLPQFE--EKDYDEtATAKDILDDFFQHIGSES--KSLDLGS-------- 319 
XP_001990148         350 GMKRGRDCPMCKEDVSWLPQIAACPHCGYKPLPIFE--EKVYNEdATANDILVDFFENLGPDF----------------- 410 
EDV93211             318 KYTPPQICPVCQANITWLPRVSACPYCGYKHYEMEPdsEQPFDEtATAAEIVNNHFLNTRGEQkrSSSPL---------- 387 
WGS:AANI:GJ10378-PB  329 KYTPPLLCPVCHANITWLPKVAACPYCGYKRFEMDKpsEEPFDEsATAAEVLRNHMLRARLGS--EENSQRKHN--SYDS 404 
WGS:AAPU:GI23385-PA  329 KYTPPLLCSVCHANITWLPKFAACPYCGYKRCDLEQpsEEPFDEtATAADVLRDHMLHTRVSS--ESSQRSRFTCSNVDP 406 
WGS:AAPP:GF16202-PA  411 lgnqEDPNLPKSCGCMG-GKPCTRCRIRKLCDNFF-KDGEC-----AQAQAQTlvsgvqgeaspvtkVEmvpKKTAsSTS 483 
XP_002073431         471 ------------------GHPMHEVNSSEALQNLL-RNYEHlkqsiKRAENGEqkkphat-tssskkGP--------TAP 522 
XP_002037320         432 ---------VEGCSAD--EEHGVPEPTSEAFEAIV-KDYQLlrrsiRESNTKAtqs--------atkNP-----TAqEGP 486 
WGS:AAPP:GF16203-PA  524 ---------VEGCPAG--KVNVENDRTSEAFEAVV-RDYQLlkrsiRESSRMKtcqp-------aveKP---TRPDpVEE 581 
XP_001998885         419 -------KISNTNTCR---DFGSESKTEEAFESIV-SDYKSlkqsiKKCKSIQ---------------P----CNKtSSK 468 
XP_002056156         320 ---------SSGCSKTC-NNQASDVKTEEAFETIV-HDYKSlkqsiKKCKSAQpcts-------sskRS---------QK 372 
XP_001990148         411 -------DSVSGCPNAGeNQQPSDMKTEEAFEAIV-QDYTAlkhsiKKCHSAQpcas-------aakPP---------PK 466 
EDV93211             388 ----PVSLTSKECTCKQvQRLCTRCRVQELCSTT------------------KlqsklqpksetvkkAPs-------TTS 438 
WGS:AANI:GJ10378-PB  405 -----IPKSSKDCTCRS-SRVCTRCRIQELCDQMLsKSSTTkvksqPQSQSQEqvrt-------lkkTAs-------TPS 464 
WGS:AAPU:GI23385-PA  407 as-cSATKITKTCTCKG-GRVCTRCRIQQLCDNM------------VDTKPKSpesksparplspkkTPs-------TPS 465 
WGS:AAPP:GF16202-PA  484 QRRKQLITIFTEMRNMYSRKKGASeedalAEKQKKDCdaaCHNTK-SAKARRKARRSLAKALK--E--IDQAYPKPPKTn 558 
XP_002073431         523 AGQQNMAAVFTELKNMFKLKDgd-----aQAKIQEICqeaQQFSS-KTHQKKGSK-------------IRDQSETSVQKk 583 
XP_002037320         487 PQPQDLAKVFTELRDLFNVKAad-----eNQKIQDICaeaCVLAK-SHKKSKKRPPSPERTKAgkAepVEDACETPRKTk 560 
WGS:AAPP:GF16203-PA  582 HKPQNLAKVFAELKDLFKAKTaee---akNQKIQDICndaCHLARlRVKKSRSQRNADRKKAGevAgaEEDPCTDPKPLk 658 
XP_001998885         469 KLPTDLVSIFAEMQKLFEVGEdds---dkKLKIKQICdeaCKLAK-ASKKHRKYSNK-----------MSDPCAEPKKTk 533 
XP_002056156         373 KQQTNLVSIFTEMKKLFDDGCdea---dkNAKIKEICedaCKLAK-VTKNRRISNSNSK---------MSEPCGAPKVRk 439 
XP_001990148         467 KSATDLFTIFTELKKICGGADada---dkKNKIKEICqeaCKLAK-VSKKRIGSKSPSK---------ISDCCAELKRRh 533 
EDV93211             439 QRCKELVKIFTEMRNFYSDKKldn--kamTDKLLKDCdkeCRKGA-K-KKRHRHTCVMKKALK--D--LEKIYPSK-KPk 509 
WGS:AANI:GJ10378-PB  465 QRRNQLVKIFTDMHDAYSDKKTPKq---lTEKLLKDCeaiASKAK-K-KGRRRQSTAMRCALK--D--LKTTYSLK-KRk 534 
WGS:AAPU:GI23385-PA  466 QHREHLLKIFSDMQKVVGGKPsak---evADNVLKQCaeiTRKGK----KGRQRSASIKKLLR--E--MEECVPTKRKKk 534 
WGS:AAPP:GF16202-PA  559 irk---kkpRPRSkyytflkpkprapnpRIGHVDCITDSKytgycKVPCHMGWMWTKCEM-ARYKSWRPGAIAKPIRQMM 634 
XP_002073431         584 kqrrqrkkpNFKSkvyamip--psgrcsKNNHELNFDGPT------VPAHMGWLWTSNPL-AKKRGWRPGSIRRSTRELM 654 
XP_002037320         561 krrp-kvkhpYKSryysmyr----pterpkeNVAIPDAGK-----KVPSHMGWLWTAHPL-ANKPGWRPGAIRRSIRGLM 629 
WGS:AAPP:GF16203-PA  659 krky-ktkrpYKSryysmykprerpprpTSVPEDI----------QVPGHMGWLWTAHPL-ASQPGWRPGAIRRSIRDLM 726 
XP_001998885         534 rrka-qpkfnVKSkvyapm---dklahpRLGHTNCFDDGR-----MVPGHMGWLWTDNPL-AKLPGWRPGAIRRSIRELM 603 
XP_002056156         440 rrkm-ahklnVKSrvyapm---eplthpRQGHVHCHDDER-----KVPAHMGWLWTHNPL-AQRPGWRPGAIRRSIRELM 509 
XP_001990148         534 kqkk-ahgspWNSrlygpv---etlnhpRKGHAHCYEYES-----KVPAHMGWLWTHNPL-AQHPGWRPGAIRRSIRVLM 603 
EDV93211             510 aksqkkkkrRVKSkrytflvrkdnlrpeVKTHHSCARELG-----RVPCHMGWLWTASEL-GRHRCWKPGAIKKPIREIM 583 
WGS:AANI:GJ10378-PB  535 pkcvkkakrRTKSkrytflvrkdnsrqpS-THHTCSRGSG-----RVPCHMGWMWTESEL-ARHRCWKPGAIKKSIRQLM 607 
WGS:AAPU:GI23385-PA  535 skcvtrkskRRKSkrytflvrkdtirqpN-THHTCSQGSG-----RVPCHMGWMWTKSELaAHHKSWKPGAIKKSIRELM 608 
WGS:AAPP:GF16202-PA  635 AYFLKDYPVDSLclsr--yhyhRRKCEPKDP---EEELIQHPTLHISRKGDEYIITLRPLkdpkslavcANPYANMKPVV 709 
XP_002073431         655 RYFLRDFPMDTIpvsrymsyykQKQPPPSDIkekAEELVQKPTLYIEKKNDEYIITLHPLkspgilehsANPYVNMKPVQ 734 
XP_002037320         630 SYFLKDFPVDNIpvskymsyykHKMLPQSPPgekAEDLVQVPTLHIEKKNDVYTITLRPLkdaktlarsANPYVKMKPVQ 709 
WGS:AAPP:GF16203-PA  727 SYFLADYPIDSIpvskymsyykNKKPPKTSSakkEEDMTQVPTLHIEKKNDIFTITLRPLkdaatlaksANPYVNMKPVQ 806 
XP_001998885         604 GYFLKDYPVDSIpiskymsyhkQKPKPSHEMaekPEDLVQLPTLHIEKKNDEYLITLRPLkdpdtlkraANPYANMKPVQ 683 
XP_002056156         510 GYFLKDFPVDSIpiskymsyhkHKKLAPHDReqkPEDLVQVPTLHIEKKNDEYLITLRPLkdpdtlkraANPYANMKPVQ 589 
XP_001990148         604 GYFLKDFPVDSMpiskyksyhnQKPAKPDNHsekPEDLVQVPTLHIEKKNDEYIITLRPLkdaaslkraANPYAKMKPVQ 683 
EDV93211             584 AYFLRDYPADRVvqsr--fhyrRQLNQ--NAadnKEPLIQHPTLHITKHRDEYVVTLRPLkepktlakaANPYENMKPVV 659 
WGS:AANI:GJ10378-PB  608 AYFLRDYPADKIgnsr--fhyrRRRQSP-DQpveEEPLIQHPTLHITKKYDEYTITLRPLkdakslavdANPYANMKPVV 684 
WGS:AAPU:GI23385-PA  609 AYFLKDYPADKIvnsr--fhyrTRKE-P-DKcavEEPLIQHPTLHIVKKHDEYTITLRPLkdaktlavaANPYANMKPVV 684 
WGS:AAPP:GF16202-PA  710 FRITKDPMAAALREMRVALQEKGFAPCSCGRPVACCFCRSHVDKKRIQYEVEKLCHQRGWEDNSDTFVYSpnsDDDESEN 789 
XP_002073431         735 FRIVKNPLLKEIRDLKRCLKGMGFKKCTCHRPVIACFCRSFIEKKQLIDELQKECEQREMESVENALVLS---DTSDSEA 811 
XP_002037320         710 FRIVKNPLLKEIRDLKRCLKGMGFSKCSCHKPLMACYCRSFVDKKRLLYHVRRECERRKIDSCEDELVLT---DTSDSED 786 
WGS:AAPP:GF16203-PA  807 FRIVKNPFIKELRDLKRCLKGIGFSSCTCHKPVMQCYCRSFVDKKRLIYCLRKECEQRKMDSCEDELVLS---ETSDSEA 883 
XP_001998885         684 FRIVKNPLLKKVRELKRCLKNMGFSKCKCHRPVMQCYCRSFIDKKQLVDELQRQCAKRELHNCENELVLS---DTTDSEA 760 
XP_002056156         590 FRIVKNPLLKQVREMKRCLKNMGFSKCKCHRPVMQCFCRSFIDKKQLVDEVQRQCHMRNMPHCENELVLS---DTTDSEA 666 
XP_001990148         684 FRIVKNPQLKQVREMKRCLKKMGFSKCTCHRPVMRCYCRSFVDKKLLVDEVQRQCREREMVNCENELVLS---DTTDSEA 760 
EDV93211             660 FRICKDPIAMGKRNIKLALKERGYPVCTCKQTVSKCHCRSHIDKKIFAQDVKMLSEEQGWTDIGDTFTYSd-lSDSDSDD 738 
WGS:AANI:GJ10378-PB  685 FRIIKDPIATGMRNIKISLKEKGYPVCSCHQPVASCFCRSHVDQKIVAQEVKLLSEDRGWRDVSDIFVYSd-lSESDSDN 763 
WGS:AAPU:GI23385-PA  685 FRISKDPIATGKRNIKLGLNDRGYDVCTCHQPVSRCFCRSHIDQKLLVEDVKILSAEQGWQDVSDTFVYSd-lSESDSDN 763 
WGS:AAPP:GF16202-PA  790 EYEFGVTPPAGVIKPERIRKP--DIAHAETQYMETDWAMPNMFPHPASMLVQYGACTM 845 
XP_002073431         812 EFEFGVTPPAGLIHPERLKKTthHIINAATQYDENDWITPSMFPHPPNRFMQYGACVV 869 
XP_002037320         787 EFDFGVTPPAGLMRPERLKSS--HVKHTETQYNESDWVNPSLYPHMPDATVQYESCVM 842 
WGS:AAPP:GF16203-PA  884 EFEFGVTPPAGLMHPERLKSS--HVKSVETQYDEADWAQPSSFPHPATPLAQYCACVM 939 
XP_001998885         761 EFDFGVTPPAGLMHPERLKVS--HRTNAETQYNENDWALPTMYPHPPNAYVQYGGCVI 816 
XP_002056156         667 EFDFGVTPPAGLMHPERLKTV--DVTNTETQYNENDWAMPTMYPHPPNPNVQYGGCVV 722 
XP_001990148         761 EFDFGVTPPAGLMKPERLKTT--DVTHQESQYNENDWAMPTMYPHPPNANVQYGGCVM 816 
EDV93211             739 ELEFGVTPPAGIVKPERLRKP--DRVNCETQYNENDWAMPTMYPHPASALVQYGGCVT 794 
WGS:AANI:GJ10378-PB  764 ELEFGVTPPAGVVKPERRRKP--DRVNCETQYNENDWAMPTQYPHPASALVQYGGCVI 819 
WGS:AAPU:GI23385-PA  764 ELEFGVTPPAGIVKPERCNRP--DRVNCETQYNENDWAMPTMYPHPPNAQVQYGGCVI 819 
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