Conserved Protein Domain Family
CARMIL_C

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pfam16000: CARMIL_C (This model is not part of the current CDD release)
CARMIL C-terminus
This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).
Statistics
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PSSM-Id: 522132
Aligned: 23 rows
Threshold Bit Score: 186.886
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023200702  783 AEGLCPHVMKRSG----------LRQELLKAAAGRMTIPCSFITNTLLEQSGVDIINKISEVKLGVASILSDHIVDEILE 852 
XP_001987365   26 GYSKCPN------------------EEQEQCETEIGV-VQPADK---------------NEIEQSLAAAISDRATDEVLE 71  
XP_002431321  763 VEEECPNIASYEE----------VTNDIRKACNEKIYIPLEFVESCIMDQAGTDIMNKTNELNLAAAAHVSDKITDEVIN 832 
4_pfamImport    1 ANEQCPTILSQTVirgdesepiaVQDDLRNTCKEKNQINNEFIHTTVTEQAGADIVNRVNELNLAVAAHISDRITDEVIE 80  
7_pfamImport    1 TRSLCPQILQGSG----------WREQLEGALVGSRGFPE-----LLPEQLLQNAFTRLRDMRLSVTGTLAESIVAQALA 65  
XP_002753698  778 TQELCPVAMRVAE----------GHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTNSIVDEILQ 847 
XP_064416196  884 TQELCPNAARSAE----------GHQKMFSSISDQVTIPRNFVRSVLLEQAGVDIQNKLNEVKLTVVSYLTNSIVDEILQ 953  coelacanth
NP_001303955  783 ARSLCPQMLQGSS----------WREQLEGVLAGSRGLPE-----LLPEQLLQDAFTRLRDMRLSITGTLAESIVAQALA 847  human
XP_036753522  709 TRSLCPQMLQGPR----------WREQLEEVLVGSRGLPE-----LLPEHLLQDAFTRLRDMRLSVTGTLAESIVAQALA 773  Chinese pangolin
XP_015134656  779 AHNLCPPMVQKSG----------ARDQLVNAMSERIHLQEHLSLSAVLDQMVTDVFSKLNEIKLSITAAVADCIVDAVLG 848  chicken
XP_023200702  853 SLSRSQHTLA--DHLIRKDH-PLLHQEPQsEAEVLDETVLHPENHdHDQKRdrd--------kkHGLND----------- 910 
XP_001987365   72 ALTR-YRRGL--GISESPSV-LL-DEPQTpDIVRSRSSHEA-----EGLI--------------IRPGGrgsil------ 121 
XP_002431321  833 QLSKNYKTLV--RR----------KRSSTpDVLRSGSRLSSNEDSeSCSFVd-----------tVSQMS----------- 878 
4_pfamImport   81 SLSRSYKTLI--GDCDSR------TRSSTpDVLRPSAGSMS-----SGSVIgvtsasgvsitlpPGRSSlvseeetpetc 147 
7_pfamImport   66 ALSAARDRLV--ESLAQQAA-VA-MPSTLpTLDGGEPISLGPG-------------------------E----------- 105 
XP_002753698  848 ELYHSHKSLA--RHLTQL-R-TLSDPPGG-PGQGQDLSSRGRGRN-HDHEE-------------TTDDE----------- 897 
XP_064416196  954 ELYLSHKKLS--RHMTQI-R-KLAEQEAGiMGILQDK----PGTNrQREAEd------------MTDDE----------- 1002 coelacanth
NP_001303955  848 GLSAARDQLVesLAQ----QaTVTMPPALpAPDGGEPSLLEPGe------------------------------------ 887  human
XP_036753522  774 GLSAARDRLV--ESLAQQAT-VA-VPPAIpAL-AGEHSPLGPG-------------------------E----------- 812  Chinese pangolin
XP_015134656  849 DLMAAQCKLA--ESLPTHGP-DLLEPAEDdAAAPARGRNPS------ELTE-------------RGFAT----------- 895  chicken
XP_023200702  911 -----------VESCM-----MTP--KSKRKSILVRM--LRPVS------------VAFE----M-EFDLDKALE--EV- 950 
XP_001987365  122 -------pklgQESPT-----ATPhlPTKRRSV-ARK--VRPQS------------V-------VeNLSLSHIPD--LL- 164 
XP_002431321  879 -----------DQSPL-----ATPhlSSKKKSLHGRK--LRPKS------------VVDS----VeGLSADHIPD--LL- 921 
4_pfamImport  148 slansigpcvnDQSPM-----ATPhlSNKRKSLHGRK--LRPKS------------VVDS----VeGLSADDIPD--LL- 201 
7_pfamImport  106 -----------LESFVfpeekEEE--DMEKERKKEKD--DSPSGkwpepshgfhlvSSIH----SaAE--EPEPE--LA- 161 
XP_002753698  898 -----------LGTNI-----DTM--AIKKQKR-CRK--IRPVS------------AFIS----GsPQDMESQLG--NLg 938 
XP_064416196 1003 -----------LSTSI-----DTI--AIRRQTVHSRK--IRPVS------------TFIS----MsELDLDRQTL--ES- 1043 coelacanth
NP_001303955  888 -----------LEGLF-------F--PEEKEEEKEKD--DSPPQkwpelshglhlvPFIH----SaAEEAEPEPE--LA- 938  human
XP_036753522  813 -----------LENLF-----FPEe-EKEKEEDEQEQkgDSPPQkwp------essHHLHlvasThSPAEGPEPEpeLA- 868  Chinese pangolin
XP_015134656  896 -----------EEYKM----------ALRRKNKHFRS--IRPTL------------TVRS----LsELELPAAGK--AR- 933  chicken
XP_023200702  951 --P-IHVED-------PPLPspppqvsdrmsysedlplPPTPSDG------------KSv-CLGELPQLEHKTLESCTKS 1007
XP_001987365  165 --E-SPSSHrsssqlsTRAAavalga-------sgataSSSVHMSdsmaaiddggvdECcdSITELPSA-SFQLQHLVKG 233 
XP_002431321  922 --P------------------------------------TIPKSAe-----------ESldSVAELP---TQQLQHLVKG 949 
4_pfamImport  202 --P----SLp----------------------------kSQAEETehs-------ltESldSVSELPNTVGQQLQHLVKS 240 
7_pfamImport  162 ----APGEDaepqagpSARG------------------SPSPAAPgppag---------alprMDLPPA-GQPLRHPTRA 209 
XP_002753698  939 ipP-GWFSG------------------------------LGGSQPta---------sGSweGLSELPT-HGYKLRHQTQG 977 
XP_064416196 1044 --PsGLLSS------------------------------STSSQYshs-------rsTSfeALIDLPT-EGTKLDHQTRV 1083 coelacanth
NP_001303955  939 ----APGEDaepqagpSARG------------------SPSPAAPgppag---------plprMDLPL-AGQPLRHPTRA 986  human
XP_036753522  869 ----APGEDaepqagpSARG------------------SPSPAAPgpl-------agPL--PRMDLPP-AGQPLRHPTRA 916  Chinese pangolin
XP_015134656  934 --P-APAKDaep---------------------------sagAHPgtp-------paQA---LMDLPT-AGERLEHCTKA 972  chicken
XP_023200702 1008 RPKLKK--RTKPSRTS---RQAtg--sSVPHDAEQNNMM-EKLDEGLDDFFSKRVV-K--LSfrLPS------IRSPSTP 1070
XP_001987365  234 RPKRAK--TRAPTRPL---VN--------AECAAFAGRD---IGDGLEHFFRPGSV--------TPTtltplvSPTSEEC 289 
XP_002431321  950 RPKRAK--TRQPTRPM---LKTsdiveKAED-----------LDSGLDTFFRPGSV--------TPTtp--lvSPTSDES 1003
4_pfamImport  241 RPRRTK--TRAPTRPM---LRP-------DQP--IDGLA---LGEGLDVFFRP--T--------TPTtp--liSPTSDDS 291 
7_pfamImport  210 RPRPRR--QYHHRPPP---GGPq---vPPALPQEGNGLS-ARVDEGVEEFFSKRLIqQdrLW-----------APEEDPA 269 
XP_002753698  978 RPRPPR--TTPPGPSR---PSM-----SAPGTRQENGMA-TRLDEGLEDFFSRRVM-D--ESssYPR------TLRTMRP 1037
XP_064416196 1084 RPRPRRnnRQPPSKPPpaqVTD------PLRQEDKNGSR---IDEGVEEFFKKKVIpDanH----PQ------TPRSRTE 1144 coelacanth
NP_001303955  987 RPRPRR--QHHHRPPP---GGPq---vPPALPQEGNGLS-ARVDEGVEEFFSKRLI-Q--QD--RLW------APEEDPA 1046 human
XP_036753522  917 RPRPRR--QHHHRPPP---GGPq---vPPALPQEGNGLS-ARVDEGVEEFFSKRLI-Q--QD--HLW------APEEDPA 976  Chinese pangolin
XP_015134656  973 RPRPNR--R--HKQPP---SKPt---vQPVAHENSEDRSiTRVDEGLEDFFTKRLI-A--EEl-PPT------VLESGPG 1032 chicken
XP_023200702 1071 T------PEA---SDKKRESRKSGFFNLIKSRTSRS 1097
XP_001987365  290 S------SLSfvdSPTMSRDGNG---HMTSEETTPI 316 
XP_002431321 1004 EktfpcqSPTynkNETKSQKLSPLLKPFTAPRSRSN 1039
4_pfamImport  292 S------LHTfp-------tDGSPNLSLTSHKSIPP 314 
7_pfamImport  270 T------EGGtapVPRTLRKKLGTLFAFKKPRSTRG 299 
XP_002753698 1038 G------LSEp-pLPPLQKKRRRGLFHFRRPRSFKG 1066
XP_064416196 1145 S------SSGeppPQKKRKGQKRSLFNFRKNRGTKL 1174 coelacanth
NP_001303955 1047 T------EGGatpVPRTLRKKLGTLFAFKKPRSTRG 1076 human
XP_036753522  977 T------DGGttpVPRTLRKKLGTLFAFKKPRSTRG 1006 Chinese pangolin
XP_015134656 1033 S------APLassSSRTLKKKIGNFFAFKKPKSSRs 1062 chicken
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