Conserved Protein Domain Family
G_path_suppress

?
pfam15991: G_path_suppress 
G-protein pathway suppressor
This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Statistics
?
PSSM-Id: 495500
Aligned: 10 rows
Threshold Bit Score: 116.2
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q7SZ61         5 LERPKLSNAMARALHKHIMRERERKRQEEEEvdKMMEQKLKEEEERKRKkemEERMSLEETKEQIMKMGVKLQGLQEEKH 84  zebrafish
XP_002403798   5 IERPKMSLQMWAALKAHIMRERERKKQEQEA--DEAIERLRREQELKRK---QDAMTLEEIKDQVSQSEKKLKELKDEKH 79 
XP_009016171  44 IVRPKMTKSTYEALKKYILKDREKKKQEQEQ--DKEQERLKKEREMKKKkeeEDNLTLEQTKEQILQLEAKLASLKQEKH 121
XP_007483264   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdKMMEQKMKEEQERRKKkemEERMSLEETKEQILKLQEKLLALQEEKH 84 
XP_005997970   5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdKMMEQKMKEEQERRRKkemEERMSLEETKEQIHKLDGKLSALQEEKH 84 
XP_049539937  18 AAKTEKEEQLWNALKRHIMRERERKKQELQA--EVEEERLRREREEREK---QDVMTLGETKEQILILEKNLEELRNEKQ 92 
Q7JQT8        16 AAKAERAEKLRGALKGFIVADRQRRQEEFEA--QCEEQRLRREREEVER---QNQVALDDTRGQITRLDEQLADLHSQKH 90  fruit fly
XP_002004692  17 AA-AERAEKLRGSLKGFILAERQRRQEEYER--QCEELRLRREQEARER---ENNLSLEDTRGQISRLDEQLADLHQKKH 90 
1_pfamImport   1 AAKAERAEKLRGALRKFIVADRQRRQGEYDA--YCEQMRVRREEEERER---ENQQALEETRDEITKLDEQLADLHSQKH 75 
Q13227         5 LERPKLSNAMARALHRHIMMERERKRQEEEEvdKMMEQKMKEEQERRKKkemEERMSLEETKEQILKLEEKLLALQEEKH 84  human
Q7SZ61        85 QLFLQLKKVLH-EEEKRRR---KE-QSDMTTLTSA-----------------------TYQANmpIHPSQHILSMQAGQV 136 zebrafish
XP_002403798  80 QLFMQLKKVLH-EDDTRRRaliKE-ANEMAAAAQAaanqayashhqalnavgvnppqpLYIQN--LSRTPVLYKMSPQPP 155
XP_009016171 122 ELFSQLKKVLHqENDLRQRnqlKEqQNEQANLqqqmltg-------------lgvnaqFFMQQqqQQQRQKYLSISsqh- 187
XP_007483264  85 QLFLQLKKVLH-EEEKRRR---KE-QSDLTTLTSA-----------------------TYQQGlaVHTGTHLLSMQGSPG 136
XP_005997970  85 QLFLQLKKVLH-EEEKRRR---KE-QSDMTTLNA------------------------GYQPGmtVHSSQHLINMQGSPV 135
XP_049539937  93 QLFLQLKKVLN-EDDNRKRq-mKE---EMMAIQNIpq--------------------qIFLPQ---------RSIC--PP 136
Q7JQT8        91 QLTVQLKKVLN-EDETRKKl-aKE-N-ELFAIQQAaas------------------spVFLPP---------LRLQ-HQH 138 fruit fly
XP_002004692  91 ELLVQLKKVLN-DDETRKKq-aKE-N-ELFAMQQEaaata--------------araqVFLPP---------GRL----H 139
1_pfamImport  76 QLLVQLKKVLN-EDETRKKq-aKE-N-ELFAMQQAaatv----------------atsVFLPT---------LRL---QH 123
Q13227        85 QLFLQLKKVLH-EEEKRRR---KE-QSDLTTLTSA-----------------------AYQQSltVHTGTHLLSMQGSPG 136 human
Q7SZ61       137 SHGRpa--------vLLG-ERSKQLFQSPVIparHFQSQPGFSAGGSEHGQysgaqpghspygvtqtqhtspFASSQPVP 207 zebrafish
XP_002403798 156 QGTTmn-------qqHPNcLKRTRSPSPPQS---IPHSQTTYQPQFAYKAQ---------------------VTAFGPKL 204
XP_009016171 188 ------------appTQTsLKRPRSPSPSTT--------PSHYPHFAGSGS----------------------------- 218
XP_007483264 137 GHSRpg--------tLMSaDRAKQMFGPQVLttrHFVGSTA-FAGTSEHGQfqgspgga-----ygaqppphYGPTQP-- 200
XP_005997970 136 GHSRpg--------pLLG-ERSKQMFAAPVItgrPYPGQPGFTPGTPEHSQyqssqsghga--yhvgqsqhaFGGGQPVS 204
XP_049539937 137 HQQHlihk----gnpQVNvAKRTHSPSSPQHl-qGYYKQPNLN-NQIYHSPqkmdegr-------rsgevarAVLWNKS- 202
Q7JQT8       139 HTlmqkl----psggQPG--KRGRSPSPPSQq-qAYYKSAA---SYAQqkhddyr-----------raadyarLSWNKTA 197 fruit fly
XP_002004692 140 HQLPllqkqppppgsQSTtVKRGRSPSPPSQqhqAYYKSPA---NYATQQPqkhddfr--------rgtdyakMSWNKST 208
1_pfamImport 124 HQqlakp----ppgnQSG--KRGRSPSPPNh---AYYKSTA---SFAQqkhddyr-----------raadyarLSWNKTT 180
Q13227       137 GHNRpg--------tLMAaDRAKQMFGPQVLttrHYVGSAAAFAGTPEHGQfqgspggay----gtaqppphYGPTQP-- 202 human
Q7SZ61       208 ANYASSSQL----------------------RGASAFQT------MQYLPHQQ-QGYAVHShf-tsQPGY---IPSAGIP 254 zebrafish
XP_002403798 205 VPYPTVSSG----------------------QTPVYYTA------HHIVPANDaAAAAAAA-----ATIY---GAGYATS 248
XP_009016171 219 -SYPNSGSGggsvgviglgqgytgkgdgpaiKQGSSYTTvllpqnHQPPPPNLiSQSPSQQ-----QHSYiqqQQQQIQQ 292
XP_007483264 201 -GYSPSQQL----------------------RAPSAFPA------VQYLSQPQpQSYAVHGhyqppQTGFl--QPGNALS 249
XP_005997970 205 MSYTGSQQL----------------------RGTPTFPT------MQYLSSQQ-SGYAVHGpf-agQQGF--------IP 246
XP_049539937 203 -QYCPPVG---------------------------FYPSnpp------snPP----QPDVRqp--qQILYp-yQSNLTIP 241
Q7JQT8       198 AQYPGTGTV--------------------------FYQTva--------pPPTtQHQADARl----QSIY-----NYNLP 234 fruit fly
XP_002004692 209 AQYPSTGTL--------------------------FYQTst--------aPATtQHQADARl----QSIY-----NYGLP 245
1_pfamImport 181 AQYPSTGTL--------------------------FYQTta--------aPPTtQQQADARl----PAIY-----NYALP 217
Q13227       203 -AYSPSQQL----------------------RAPSAFPA------VQYLSQPQpQPYAVHGhfqptQTGFl--QPGGALS 251 human
Q7SZ61       255 LQKQle-----------------haNQQSGFTDSSPLRPm-HPQALHVSAASLlsTPPIA 296 zebrafish
XP_002403798 249 FTTA---------------------APPQPHPTESTLKQ--HVVAPPSSQGYA--ASHLP 283
XP_009016171 293 QQRQ---------------------QAPSPYQIPSNQKYhqSSSSSSPASGYFpsSNHFS 331
XP_007483264 250 LQKQle-----------------haNQQSGFSDSSSLRPm-HPQALH-PTPGLlaTPQLP 290
XP_005997970 247 LQKQle-----------------haNQQSGFTDSSTLRPmqHPQALH-PNPGLlaASQIP 288
XP_049539937 242 MRQYvdipptqqhqqqhqqhqqqhlHQSGLLKQSEPPHMvqSSKAIMGQ-AAQpnIYHIs 300
Q7JQT8       235 LRQAyhv------------------dlPSATVSKPPDSQ--SPKAPSQSQPMQ--VLHIn 272 fruit fly
XP_002004692 246 LRPPyhv---------------elqPGPSATVSKAPGSQspSPKA----QPMQ--VLHIn 284
1_pfamImport 218 LRQAyhv------------------elPSATVSKASDTQ--SPKA----QPMQ--VLHIn 251
Q13227       252 LQKQmehanqqtgfsdssslrpmhpqalhpapgllaspqlpvqmqpagksgfaatsqpgp 311 human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap