Conserved Protein Domain Family
Cadherin_tail
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pfam15974: Cadherin_tail 
Cadherin C-terminal cytoplasmic tail, catenin-binding region
Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.
Links
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Statistics
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PSSM-Id: 435046
Aligned: 4 rows
Threshold Bit Score: 188.305
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004912839 834 KHPHPDWRYSASLRAA--MQGAVHMEGAAVLRGGAGGLEQQWPTVSSATPEPEGGEVSPPVGAGVNCNSWTFKYGPGNPK 911 
XP_006632080 824 KPPNTDWRFSQGQRPGp-SGAPQRPEEAGPWPNPPTEAEQLQALMAAANEVSEATNTLGASTLGPGTMGLSTRYSPQFTL 902 
Q9Y5H9       798 RQPNPDWRYSASLRAG--MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPK 875  human
XP_029702907 442 KMPSADWRYSASLRAGgvMQSSVHMEESSVMQGAQGVLVQNWPTASSAA-DAEGGEVSPPMGAGVDSNSWHFRYGPGGPG 520  torafugu

XP_004912839 912 QP----VPQippdFPENFIIPGSPAIISIRQDQPSAQ-NQKNFITFGK---------KEETKKKKKKKKGNK 969 
XP_006632080 903 QH----VPD----YRQNIYIPGSTATLTGNNPQAQTQ-AQVQVQALPQpqpaaveapKPAQTPANKKKSGKK 965 
Q9Y5H9       876 QS----GPGe---LPDKFIIPGSPAIISIRQEPTNSQiDKSDFITFGK---------KEETKKKKKKKKGNK 931  human
XP_029702907 521 APpqhlKPGev--pPEAFIIPGSPAIISIRQNQGGED-DKSDFITFGK---------KEEAKKKKKKKKEKK 580  torafugu
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