Conserved Protein Domain Family
Piezo_TM25-28

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pfam15917: Piezo_TM25-28 (This model is not part of the current CDD release)
Piezo TM25-28
Piezo is a family of proteins that form mechanosensitive non-specific cation channels whose conductance is higher for Li+, intermediate for Na+ and lowest for Li+. Divalent ions except for Mn2+ permeate the channel but more slowly than monovalent ions and can reduce K+ currents. These channels have a homotrimeric three-blade propeller-shaped structure that use a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Each protomer consists of 38 TM helices (referred to THUs) that form unusual non-planar blades, and an extracellular cap-like structure (pfam12166). This entry represents TM25-28, found in the central region of these proteins, following pfam24871 and associated with pfam12166 at the C-terminal.
Statistics
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PSSM-Id: 522099
Aligned: 19 rows
Threshold Bit Score: 482.247
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002933721  1124 EAPKDRP-NPVPNFINCQSYLDMVKVAVFRYLFWFVLTVVFITGATRISVFGLGYLMSCFYLLLSGTTLLQKPMKAKLVL 1202
2_pfamImport     1 DPRALSQyTPVSNFLHCRSYLDMVKVFVFSYFFWLVLCLIFITGTTRINIFCLGYLMACFYFMLFGGSLLLQPVRHILRL 80  
13_pfamImport    1 DPMDLNEySPVPSFIHCRSYLDLSKVIVFRYHFWFVLCLIFMTGTTRINIFCVGYLAACFYFMLFGGSLQLKPVKDILIL 80  
XP_064414487  1158 DPIKGKEeNPVPNFMNCRCYLDMVKVVVFRYQFWFVLAVVFVTGATRTSIFGLCYLLACFYLLLFGTALLQKPAESRLAL 1237 coelacanth
XP_056679622  1267 DAASFSQhNPVPDFIHCRSYLDMYKVVIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRY 1346 gray short-t...
XP_064420242  1037 DSTFLNQfVSVPNFINCRSYLDMAKMVAFRYLFWFVLSLIFVTGTTRINIFCPGYLMACFYFMLFGGSLLLRPVRHILRL 1116 coelacanth
XP_028926177  1117 IPEDLSQfSPVPNFIYCRSYLDMAKVIVFSYLFWFVLGVVFLSGTARVNIFCFGYIVAFFYFMLHGSSLLLKPVKFILHK 1196 platypus
XP_029689272  1227 DPCSFNQfIPVNNFLHCRCYLDMVKVFVFSYFFWLVLCLIFITGTTRISIFCLGYLVACFYFMLFGGSVLMQPVRYILRL 1306 torafugu
XP_036736598  1258 DAASFSQhNPVPDFIHCRSYLDMSKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRY 1337 Chinese pang...
XP_029687576  1285 DAASFSVhNPVPDFIHCRSYLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKKILHY 1364 torafugu
XP_002933721  1203 WDCLILYNITVILSKNMLSLLSCVFVQQM-QTNFCWVIQLFSLVCTVKGYYNpqd-mdKDRDCSLPVEEAGIIWDSICFL 1280
2_pfamImport    81 WDWLIGYTCLVIATKNLLSLGSCAYLDSL-LKNGCWFIQTFSMFCTIKGYNVp----pPSDECELPKSEAGIVWDAICFI 155 
13_pfamImport   81 WDYLIAYTALVITMKNLLAIGACAYLNKL-QRNHCWLIHTFGMFCTVSGYNIgklyppDDEICELPEKDAGIGWDVICFM 159 
XP_064414487  1238 WDCLILYNIAVIISKNMLSLLSCVFVKQM-QNKFCWVIQLFSLVCTVKGYYNpke-mnKDEDCSLPVEEAGIIWDSVCFF 1315 coelacanth
XP_056679622  1347 WDWLIAYNVFVITMKNILSIGACGYIESL-VRNSCWLIQAFSLACTVKGY-Kmp--ldHK-DCKLPSGEAGIIWDSICFA 1421 gray short-t...
XP_064420242  1117 WDYLIAYTVLVIAVKGALSIGACVYLDKL-LKNNCWLIQTFSMVCTINGYDLpv---pEDGKCELPEDEAGIVWDAICFT 1192 coelacanth
XP_028926177  1197 WDYLIAYNVLVIALKNLLSVGACAYLEKL-LSSHCWLVHSFSMFCTVKGYSLai---pDDENCELPEKEAGIFWDVICFS 1272 platypus
XP_029689272  1307 WDWLIGYTCFVITMKNLLSLGSCAYLDSL-VKNSCWLIQAFSMFCTIKDYDVp----dPDEDCELPEGEAGIVWDAICFT 1381 torafugu
XP_036736598  1338 WDWLIAYNIFVITMKNILSIGACGYIEKL-VQNSCWLIQAFSLACTVKGYKMp----dDDSSCKLPSGEAGIIWDSICFA 1412 Chinese pang...
XP_029687576  1365 WDFLIAYNIFVITMKNILSILACGYINSLmVNH-CWLIQLFSLACTIKGYNInnm-qtSEQICDLPRNEAGIIWDSICFA 1442 torafugu
XP_002933721  1281 FLLLQRRVFLSCYFRHVVLDLRASSLQTSRGFELFMASIRKNVFFHQESERRSLNQLRKQMERIRAKQERYHEG------ 1354
2_pfamImport   156 FLLAQRRVFLSYYFLYVVSDLCASKILASRGAELFEAKVKKQVAARLEQEKKSVEMLKKQMEKIKSKQRRFEGG------ 229 
13_pfamImport  160 FLLVQRRIFTSYYYLYIVADLKAAKILASRGAELFKVKLKKTVDLRIEEERKSMETMKRQMDLMKPKQKRVNGL------ 233 
XP_064414487  1316 FLLLQRRVFLSFYFLHVTADLKASALQASRGFQLFKASMMKNMNLHQDVEQKSIVQLKRQMERIRSKQQKHREV------ 1389 coelacanth
XP_056679622  1422 FLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARMEEEKKSMDQLKRQMDRIKARQQKYKKG------ 1495 gray short-t...
XP_064420242  1193 FLLAQRRVFMSYYFLHIVDDLKASKILASRGAELIEAKVKKGITARLEEETKSIRNMKKQMEQIKLKQKKFQDV------ 1266 coelacanth
XP_028926177  1273 FLLIQRRIFTSYYHLYVVAEQRATRILASRGAEMFELKLQKSIVIQEEKERKSKLATTKQMDKIKTKQKKIESA------ 1346 platypus
XP_029689272  1382 VLLAQRRVFLSYYFLYVVSDLKSSKILASRGAELFEAKVKKLVAARLELEQKSVETLKKQMEKIKSKQKSRPSA------ 1455 torafugu
XP_036736598  1413 FLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGkermls 1492 Chinese pang...
XP_029687576  1443 FLLLQRRVFMSYYFLHVVADIRASQILASRGAELFQATIVKAVRARLEEERKSVEQLKRQMERIKVRQQKFKRG------ 1516 torafugu
XP_002933721  1355 ----RRQTDSSQv-----KEGE----------------------P--------------GSKKGSSRQKIHWSRPWLDHA 1389
2_pfamImport   230 ----EGAPAVQGd-----ADVD----------------------Ptqeed----rdsqgGSEKGDKRDRKKWWRPWVTHS 274 
13_pfamImport  234 ----DKRTSE----------TE----------------------Tvqeser--ekdsedGGSKKENEGKKTWWQPWVTHT 275 
XP_064414487  1390 ----R-------------APKD----------------------Phgsaeh---epierDGSRRPLRHKKKWWRPWLDHA 1427 coelacanth
XP_056679622  1496 ----KERMLSLTqesgegQSLQ----------------------Rvseed-----dereADKQKAKGKKKQWWRPWVDHA 1544 gray short-t...
XP_064420242  1267 ----KSSA------------------------------------PtqelmtedsdialkNTEKDE--------------P 1292 coelacanth
XP_028926177  1347 ----KQDSMSPgd----lEVKT----------------------Pspqktea-egqphdDSGLQETGDQKKWWQPWVHHP 1395 platypus
XP_029689272  1456 ----VDTPAL----------------------------------Pvcpe------qetlNDEEKAKRDAGKWWKPWVSQP 1491 torafugu
XP_036736598  1493 ltqeSGEGQDIQ-------KLSeeddereadkqkakgkkkqwwrP-------------------------------WVDH 1534 Chinese pang...
XP_029687576  1517 ----KekmlsiaqesgdgQTLI----------------------Qpedd------ddddD-------------------- 1544 torafugu
XP_002933721  1390 S-VLHSGDYFLFESDS-EEDEESl----LEQDQRPPKQSAFQ---------------------------------LAYQA 1430
2_pfamImport   275 S-MVRSGSYYLFESDS-EEEEEEpe--gKEEEAPAKKKTAFQ---------------------------------LAYEA 317 
13_pfamImport  276 S-MIRGGSYCLFETDS-EDEEEEervaeKNEEEALKKKTAFQ---------------------------------LAYEA 320 
XP_064414487  1428 A-VLHSGDYXLFESDS-EEDEEa-----VGEEQKPLKQSAFQ---------------------------------LAYQA 1467 coelacanth
XP_056679622  1545 S-MVRSGDYYLFETDSeEEEEEE-----EKKEEEPPRKSAFQraigkfasailalpksviklpktilqyliraakFVYQA 1618 gray short-t...
XP_064420242  1293 PqVIRSGSYYLFETDS-EDEVED-----EEKEKPLKKKTAFQ---------------------------------LAYEA 1333 coelacanth
XP_028926177  1396 S-MVQEGSYSLFETDS-EEEEDEeeekeEKEEEFPKPKTAFQ---------------------------------LAYDA 1440 platypus
XP_029689272  1492 G-VENNCGYHLFESDS-EEEEEEat-ekKEEDEPTKKKSAFY---------------------------------LAYNA 1535 torafugu
XP_036736598  1535 AsMVRSGDYYLFETDS-EEeeeeelkred------------------------------------eepprrsafqFVYQA 1577 Chinese pang...
XP_029687576  1545 --VVRSGDYYLFETDS-EEEEEDe----EKKDDDSPKKSAFQ---------------------------------FLYHA 1584 torafugu
XP_002933721  1431 WVTSAKSALKERKSR 1445
2_pfamImport   318 WVTSSKAALKGREKE 332 
13_pfamImport  321 WIMSSKSALKMREQD 335 
XP_064414487  1468 WVINAKSALRERRDH 1482 coelacanth
XP_056679622  1619 WITDPKTALRQRRKE 1633 gray short-tailed opossum
XP_064420242  1334 WTTSSRSALKVRHKE 1348 coelacanth
XP_028926177  1441 WTNNSKTALKLRKQD 1455 platypus
XP_029689272  1536 WATSSRkalkdlkke 1550 torafugu
XP_036736598  1578 WITDPKTALRQRRKE 1592 Chinese pangolin
XP_029687576  1585 WITDPKAALRARGre 1599 torafugu
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