8FGW


Conserved Protein Domain Family
Beta-prop_WDR19_2nd
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pfam15911: Beta-prop_WDR19_2nd (This model is not part of the current CDD release)
WDR19 second beta-propeller
This entry represents the second beta-propeller of human WDR19 (also known as IFT144) and its orthologue from C.elegans, DYF2. WDR19 is a component of the IFT-A complex which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), being involved in cilia function and/or assembly. IFT-A polymerises interacts with IFT-B, and uses an array of beta-propeller and TPR domains to create 'carriages' of the IFT train that engage TULP adaptor proteins. Proteins in this entry are part of the core of the complex which is important for TULP3 localization to the cilia. The core of the complex is formed by the beta-propeller domains of its components (WDR19, IFT140 and IFT122).
Links
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Statistics
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PSSM-Id: 522095
Aligned: 11 rows
Threshold Bit Score: 378.24
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8FGW_C        361 IAYLTSLLEVTVA-NPVEGELp---ITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGEN------AVKKLKDMEYLGTV 430  human
XP_002499978  283 CAYLTSLLEVTVA-DISLNKL----RAVAIDQEPVFLALGHQHVAAGMNNQAWFYRVGPPeegleyPPERVNQREYMGSV 357 
XP_002400651  359 YAYLTSLYEVTVA-SVTEPELq---MTVKVDIEPGFIALGPFHLVVGMNNRAWFYALGDK------SMLPLQDKEYLGTV 428 
XP_002117569  360 LAYLTSLLEVTVLpNFHEEENs---LKIDIEVEPSFIALGPYHLAVGMNNRVWFYYFEES------GPQKLNEKDYLGTV 430 
XP_011473231  362 LAYLTSLLEITVS-NQVEGEKp---VTIEVEVEPTFIAVGPYHVAVGMNNRAWFYALDDQk----pGFNLLKDTEYLGTI 433 
XP_046437980  365 IAVLTSLKEVTVY-DVALNTI----CNVQCELEPVFLACGPKAIVLGLNNHVWLYSAv--------NGHLQRKLQYAGSV 431 
EGI69286      257 IALLTSLMEVAVH-LYTLDKDkpspQIINTIIEPAILAVGPIHLAVGLNNRALFWDLSIShydq-----ihfERDYLATI 330 
XP_004995006  366 VAYLSSLQELTVL----PDEGa--pIKIKLPIEPATVAVDEFYAACGMNNTAWFFLLDDGrae----eidTEPRTYTGSI 435 
XP_009020224  363 VAHLTSLREITLE-NPADGGQs---RTYMVEVEPSFIGLGANHLAVGMNNTVLFYGFKKN------ALVKVEEKEYLSSI 432 
XP_002949176  375 VLYLTSLLEMTVL-DVTKRQTv---ARIELETEPAFCGLGPQHAAMGMNNQVAFYNVEGK------AGKVVQRRDYLGTI 444 
XP_011610886  361 LAYLTSLLEVTVF-NQVEEENp---VVIEVEVEPTFIALGPYHVAVGMNNRAWFYALNEQe----pGFIQLKNIEYLGTI 432  torafugu

8FGW_C        431 ASICLHSDYAAALFEGKVQLH--LIESeildaqe---eretrlfP-AVDD----KCRILCHALTSDFLIYGTDTGVVQYF 500  human
XP_002499978  358 DEVSMNDTLAAVRSEGRVNVH--VIEHnd--------------dPtESMDfqlpAADITSAAMTRDFLVYGTASGNIVYY 421 
XP_002400651  429 KSMKLNGDYAAALFDGKVQMQ--LIETeqsdmee----resklfP-DSSQg---QAKITCHSVTEEFLMYGTDAGTIEFF 498 
XP_002117569  431 STIRLNSDYAAAMLKNKIQLH--LIETdesglgh---dretklfP-EEDD----KTVITCYDLTKNFLIYGSDAGNIQYF 500 
XP_011473231  434 VSMHLNSDYAAALFEGKVQLH--MIESrhqeer-----kqmklfP-DDVK----KSRILCHALTSDFLYYGTDMGNVVCV 501 
XP_046437980  432 ESICLNETHVAALVDGKVHLQ--LIEeasfssdggnglmdsgvfPlRESS----TAKIGSHALAKDCLVYVTSVGDLVYF 505 
EGI69286      331 DSIRLNETYVSALFDGKLQLH--SIKSdqalins---gkdtkmfP-DSNSs---HSRITCHALCSDFLVYGNDMGHIIYF 401 
XP_004995006  436 KSIKLCGQYAAVHCGKKVHLH--LVEShpeddmp----nsekmfPaKSSD------VIDGVALTKNFLIYSTTEGAVYYF 503 
XP_009020224  433 QSIKLNDKYVSAHSDGKLVLS--LVSSffsidqq------qqqqqqQQQQq---QAKITSHHLTTDFLIYTTDKGTINYF 501 
XP_002949176  445 SAIKLNETQAAVLTGGHVVVHpiVVESgrapde------hdvviP-GPGQ----PANITCVALTPTFVITGSRTGTLSYY 513 
XP_011610886  433 ASMCLNVDYAAALFEGKVQLH--MIEGkdqdek-----rqmklfP-GDTR----KGRILCHALTADFLYYGTDSGDVECV 500  torafugu

8FGW_C        501 YIEDWQFVNDYRH-----PVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVN--DATYEIPDFSPTIKGVLWEnwPMDKGVF 573  human
XP_002499978  422 YLPGKTAVSEYRHevegvECGIVKVYPNQLGTRCAFIGFDGVAMVYNPVS--NQSYPMPEVGSTVQAILWD--VHDPNTV 497 
XP_002400651  499 FLEDWTIVNRYRH-----TNGIRQIHPDSSGTRLVVVDNKSEGFIYNPVN--DHIVVIESFPTTTKGIFWDqyVENHGCF 571 
XP_002117569  501 YIEDWKFVNEYRH-----GIGIRKVCCNPSETILIYIDDKNDGFIYNPIN--DATVDIPDFSPTVKGVLWEswPSDKGVF 573 
XP_011473231  502 LVEDWETLSTYSH-----PVGVRKVFPDANGTHVVFIDDENSGFLLSPANvtASCFELPNFSPTITGVLWDtwHADRGVF 576 
XP_046437980  506 SLSERKPVSEYRH-----AVGWKKIYHDTSGTLLAAVDIKNHGYLYSPVK--EILLRIPDFPVHHRGLLWEsaSRISHVF 578 
EGI69286      402 CLETFHQCTEFIH-----NNGIKELYLDANGVQLCFIDNKLDAYVFDPIN--EAAIAVPDCPDNIDDILWD-----QNIF 469 
XP_004995006  504 SLEDWQFVNEYKH-----PCGLSGLTADSSGTRVAFIDAKGDGIIYSPVD--DTTLTLPNFPSRPKGFVWDv-ACEEKVF 575 
XP_009020224  502 HLADWCPILEYHH-----ICHVTKSQPDVSGGRVVLVDEKGDCALYHAFF--DSILPIHDTPQKVAGVLWDewSHDKNIF 574 
XP_002949176  514 LSPDVTPVNEYRHd----DGGITRLFPQATGARLVFEDDKGCLHLFNPVN--DHVVPIPNFSGRADVVMWD--TSDINVL 585 
XP_011610886  501 LVEDWDTVSSYRH-----SVGVRKVFPDQNGTWLVFIDNKNSGFLLCPAKgtKFFLELPDFSPTITGVLWDtwRDDKGVF 575  torafugu

8FGW_C        574 IAYDDDKVYTYVFHKDTIQGAKVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTH 635  human
XP_002499978  498 VVATGAEFQVYTFADVTINGSMVEAVGSHPQMPGAFPVLFSLGKVTCQVPGGRIHTELLSTH 559 
XP_002400651  572 VAFDDHNISMYVYTPETVAGATVEPVRTISVPSGQNPLLLHCGSLTCQTQSGKTAVLLVSSQ 633 
XP_002117569  574 CTYDDQNVYTYIYWSDSIFGPECKLIGKTKLPFNQVPFLLYDGEVICQTQNGKTARVVLTTH 635 
XP_011473231  577 VAYDNDKVYTYAFHKTTVYGPRVVLVGSAALLFSQKPLLLYNGELTCQTSSGRTSELALSTH 638 
XP_046437980  579 VAWSDEKLDVFVYHAERLTGSCIIRLCSSPLASGHTPLLLQGPDLLLLTASSKLTTLFIPEL 640 
EGI69286      470 e------------------rTKIIKINTTKLPSDSVPLLMYSGEVTLSTMGSKLIQLTLTSH 513 
XP_004995006  576 IVYDEENIYTYVEHSEHIDGAHCEFVGLTKLQYGLVPIRLDDGRVTCLTPSGKTTAVTLSTH 637 
XP_009020224  575 IIYDRDSIHTYCHLRETLKGPQVILAGTTKLPYNHQPILLLAGNLTLLTPSGSTTDLYLSSH 636 
XP_002949176  586 VIADGSALHTYLYIPVSLNGPQVQFIGKQPLGATHTPLTVCNGVVGCRLKNGAMDNVILESH 647 
XP_011610886  576 VAYDDDKVYTYAVHKTTIYGPQVVLVGSSPLLFSQKPLLLYNGELTCQTASGKTNDIPLSTH 637  torafugu
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