Conserved Protein Domain Family
HMMR_N

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pfam15905: HMMR_N (This model is not part of the current CDD release)
Hyaluronan mediated motility receptor N-terminal
HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Statistics
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PSSM-Id: 522091
Aligned: 10 rows
Threshold Bit Score: 191.167
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005053959  20 CTPLQGSHSAKPSDGVGSLLSSEACQGVRKQK-----SVANLSSEKSAPTPVTARRLTSLGSTPang-ivKTKKDLml-- 91  
XP_008111416  17 CAPPPGSYDVKTSDASKGPISFEKSERFRVQTgd-veTQPNRSHMKPPPSPANGRKVTLQKSKKpnssgmKVEKDLtv-- 93  
Q00547        17 CAPSPGAYDVKTSEATKGPVSFQKSQRFKNQRe----SQQNLNIDKDTTLLASAKKAKKSVSKK------DSQKND---- 82   house mouse
4_pfamImport   3 CAPSPGAYDVKMSEALKGPVSFQKSERFKKKKd----SQQNSNVDKDATLLASERKVKTLELKK------ESQKND---- 68  
6_pfamImport   3 CAPPPGSYEIKTGD-LKGAASFDKSDRFKPPKaa-amPPPPPSPSRNTLVSPVRRTLSLDVLKD------SLSFDS---- 70  
XP_003390449  14 TIPPVGAYDV-STDAKRIGGTFEKGSRFRq-------SSPSSDRSGDSSTTSASSKYSSSSLKRp-----KQQTKPask- 79  
XP_064422998  17 CAPPPGSYDVKPTEGLRGPVSFEKSQRFKKQKgk--eNQQLVGNEKELSS--------------------STQKSLsnss 74   coelacanth
XP_057347468  17 CAPSPGAYDVKTSDVLRGPVSFQKSQRFKKQKe----SQQNLNVDKDTTLPALARKFKTLGLKK------ESQKND---- 82   Chinese pangolin
XP_007474038  17 RVPSPGAYDVKTSEIPKGPVSFEKSQRFRRHQaafmeNQEGINNGKDRLTTTTAKNTKPLELKT------KSQKNV---- 86   gray short-tai...
XP_028906864  17 CAPPPGSYDVKSSEVLKGPVSFEKSQRFRKQKatfvgSQQSLNSDKDAASPPTARKHKILESQK------KAQKDS---- 86   platypus
XP_005053959  92 --------------mKEKKKQK-------ALEKE-IRALVRERGEQDKKLKALDEDLVKIEAKLSA----AVQEKTSLSA 145 
XP_008111416  94 --------------lKDMKKQK-------ELEKE-IRLLTGERSQQDKRLQALEEDLAKAEAKLCA----VVREKTSLLE 147 
Q00547        83 ------------------KDVK-------RLEKE-IRALLQERGTQDKRIQDMESELEKTEAKLNA----AVREKTSLSA 132  house mouse
4_pfamImport  69 ------------------KDLK-------VLEKEhTKEQIQGNTLREKLINNIDCRLGACSSVISAlatcALAEKKKNSS 123 
6_pfamImport  71 --------------------------------SQ-IRSLVQQRGEQDRRLLSLEEELKKVEAKLLA----AIRERTGLTA 113 
XP_003390449  80 -------------ttNSSSDHHslpgniaELEQQ-IRKLVLENTELNKQVSQGKQEAVRLDGKLQT----LTKDKLELQA 141 
XP_064422998  75 vssssnqsekdtvflEENNKQK-------MLEKE-IRRLVLEQGEQDKRMQAIEEQHRKKEAKLTA----ALREKTALSA 142  coelacanth
XP_057347468  83 ------------------KDLK-------TLEKE-IRVLVLERGAQNKRIQELEAELEKMEAKLNA----AVREKTSLSA 132  Chinese pangolin
XP_007474038  87 ---------------KELKKLK-------IQEKE-IRALVQERGIQNKHLQDLEAEFEKMEAKLNI----AVREKTSLLA 139  gray short-tai...
XP_028906864  87 ---------------KDLKRVK-------MLEKE-IRDLVKERGMQDKRHRDLEAELEKTEVKLNA----AVREKTSLSA 139  platypus
XP_005053959 146 NVACLKKQLLEITRSNELLKSKLSEDGV-QKKMSSLCMELMKLRNMRDAKeK---------------------------- 196 
XP_008111416 148 NVASLKKQLLDLSRTNELLKTKCFEDGT-QKKMSTLMVEVMKLRHRLTAK-R---------------------------- 197 
Q00547       133 SNASLEKRLTELTRANELLKAKFSEDGH-QKNMRALSLELMKLRNKRETKmR---------------------------- 183  house mouse
4_pfamImport 124 SKQSVAAVLVE----GCFFYQKFSENGN-QKNLKILSLELMKLRNKRETKmK---------------------------- 170 
6_pfamImport 114 SVTTLERQRAELKKVNEFLKNKVSADTT-KKRINSLTMELMEARNTLDVKnQ---------------------------- 164 
XP_003390449 142 AIAVLERENRDLVRGKDILQAKAAATPD-NKRLQT---ELTQTHKELEATqK---------------------------- 189 
XP_064422998 143 TVASLEKQLSDSKRVNELLKTKFSEEST-KKKMNALCAELMEAKNQVYSKdKdlgikmktkeekherekqlavsnveeqy 221  coelacanth
XP_057347468 133 TNASLEKQLIELTRTNELLKSKFYEDSN-QKNMRILSLELMKLRNKRETKmR---------------------------- 183  Chinese pangolin
XP_007474038 140 NIASLEKQLIELTRANEILKIKFSEDGNhQKKISLLSLELMKLKNKMETKkK---------------------------- 191  gray short-tai...
XP_028906864 140 NIASLEKQLMELTRANEFLKLKFSDDGT-QKKMSSLSMEVMKLRSKMEAKtK---------------------------- 190  platypus
XP_005053959 197 -TALAKQEDMEMKLQEVQRNLEHSKGKVAQLQQKLSATEREk---VEEKSDT-EKLLEYITELSSVAETA-EKYKLEVTQ 270 
XP_008111416 198 -VTFVRQRDMESKPNATQEPMEHSKEKVAQLEEQLMEMYKQ----AEEKYDS-LKLLEYITELGNVAEQVgDKYNLDIAY 271 
Q00547       184 -SMMVKQEGMELKLQATQKDLTESKGKIVQLEGKLVSIEKEk---IDEKCET-EKLLEYIQEISCASDQV-EKCKVDIAQ 257  house mouse
4_pfamImport 171 -NVTAKQEGMEVKLQVTQKNLEESQERIAQLE-KLVSTEKDk---IDEKSET-EKLLAYIEEISCASDQV-EKYKLDIAQ 243 
6_pfamImport 165 -EFSVLQINTEGQIKVLETDLQAARATLAALKDRNKDLEDLh---QVTKSQN-EELENENARLHAVIREL----REEIRV 235 
XP_003390449 190 -EV----QKLTGQLQSTQKHL---KAEVSNLKEKN----------NEQKAHV-QQQVAEIKRIQNEREQL----SLDLQK 246 
XP_064422998 222 kAAMAKQEQLEKDLQEAQTNLNQSVMEVAQLQDKLSVTEQEkcrlMEEKEQTvKKLTECTTELSQLTEKV-EMYKKKSDL 300  coelacanth
XP_057347468 184 -SMMAKEDSMEAKLQVTQKNLEESQGKIAQLEGKLFCLEKEk---INEKSET-EKLLEYIEEISCASDQV-EKYKLDISQ 257  Chinese pangolin
XP_007474038 192 -NVVDKQEGMEIKLYSAQKNFHHFQGNLSQLEEKIVTSEKEn---IEEKLEI-ENLLKYITEISCTSDQM-EKYKLDIVQ 265  gray short-tai...
XP_028906864 191 -SAAAKQEDMEMKLQLAQRNLQQTQGIVAQIEEKLLSTEKEi---VEEKSDT-GRLLDYIEQLSCLGER--EKYKEDIFY 263  platypus
XP_005053959 271 MEETLSKKDQEIEILRNTLKAKEEESCKLMKDLNERCQLLQ------QEKEKELSEAEGQFLSRNAEIEDLKKKIDLVEQ 344 
XP_008111416 272 LEEIIEAKNKNIETLQSALQQKETMLSTQVEEMNEKCKMAE------EQKEKMLTEYEVKKQTMNVEMECLKEQLNLEKQ 345 
Q00547       258 LEEDLKEKDREILSLKQSLEENIT-FSKQIEDLTVKCQLLE------TERDNLVSKDRERAETLSAEMQILTERLALERQ 330  house mouse
4_pfamImport 244 LEENLKEKNDEILSLQQSLEENIV-LSKQVEDLSAQCQLLE------KEIENLVNRNRELDENLNAEIQNLKEKFILEKE 316 
6_pfamImport 236 VQGYLDAANDENQELRLKIQEKTQ--YTVAGSQVEKLKQLE------SELE-----------RRVSELETTQDALRQKEE 296 
XP_003390449 247 SKELAATQASHLESVQSELSASKQHLEATTNERDELVKELEtlkvklSSTEEKLREEETKSQGYLKELGEMEETVTSKSN 326 
XP_064422998 301 AKELLEQKERDLVTLKTDLKAKEVELSEQIKFLDEKCKVIE------HEKEQVETEYREKESTLKAELDMLKHTINQQEQ 374  coelacanth
XP_057347468 258 LEENMKEKNHEVLSLQQALEENIALFSKQVEDLNAKCQLLE------KENEDLVNKDREKDDSLNSEIQNLKEKIILEKQ 331  Chinese pangolin
XP_007474038 266 LEETLNQRNQEILVLKQSLDENVDVLSKNIKDLNTRCDTLE------KEKEELVRQGKEQEQNLSTEILSLKERLTLEKQ 339  gray short-tai...
XP_028906864 264 LEEIFKEKNNELSILKNSLEEKDCALSRKIKELTSACQLLE------EENGRLIAEHKEQEHNLNVSLQSLKEKLQL-EQ 336  platypus
XP_005053959 345 EhqklLQK 352 
XP_008111416 346 E----QQK 349 
Q00547       331 EyeklQQK 338  house mouse
4_pfamImport 317 EyeklQQK 324 
6_pfamImport 297 EvcklQQD 304 
XP_003390449 327 EiqemNKK 334 
XP_064422998 375 GetelQQK 382  coelacanth
XP_057347468 332 EreklQEK 339  Chinese pangolin
XP_007474038 340 EneklAQR 347  gray short-tailed opossum
XP_028906864 337 EhqklQQE 344  platypus
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