Conserved Protein Domain Family
LIP1
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pfam15904: LIP1 (This model is not part of the current CDD release)
LKB1 serine/threonine kinase interacting protein 1
LIP1 is a protein found in eukaryotes. It represents the N-terminus of a leucine-rich-repeat protein that is implicated in Peutz-Jeghers syndrome. LIP1 interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases.
Links
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Statistics
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PSSM-Id: 522090
Aligned: 6 rows
Threshold Bit Score: 126.08
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001962711    1 MDPQK-ITELANLLRQN--GDKILSSEFTLTLSGSLLRALNDSFTLIADTEvSHDQGFQVVKPINAKSSVFPDLQLLHDF 77  
3_pfamImport    1 SGGSTlVHSLASLLRNNdeGDSVLDGTSTLSLMASSLQHLTRLFEQYLLSR-THQHGFLALPSHPADTASLLQVQFLFDM 79  
XP_011482066    6 SGQSSlVHSLATLLRNN--GDVVLDGSSTLTLPAASLQQLTRLFEQHLLPR-SHQHGFLALPSHPADTVSLLELQFLFDI 82  
Q5F479          7 AAAEPlVSGLARLLQDT--GDLVLDGSSTLTLLTPTLQHLTRVFEQHLGSR-NQHRGFVALPSHPAETTAILQAQFLFDM 83   chicken
XP_056707007    5 tqKAMmLQSLAQLLQDS--GDLILDGTSTLTLFTSTLHYLTQIFEQHLIPR-NQNHGFIALSSHPTETSAILQAQFLFDV 81   tarantolino
XP_029696317    6 SSQCPlVHSLAKLLRND--GDLVLDGSSTLTLTASSLQQLTRMFEQYLLPR-SKQHGFLALPSHPADTASLLQLQFLFDV 82   torafugu

XP_001962711   78 VQKTTLLKLTHFP 90  
3_pfamImport   80 LQKTISLKKNNLK 92  
XP_011482066   83 LQKTVSLKLINPP 95  
Q5F479         84 LQKTHSLKLIHVP 96   chicken
XP_056707007   82 LQKTLSLKLIHVP 94   tarantolino
XP_029696317   83 LQKTISLKLINPP 95   torafugu
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