Conserved Protein Domain Family
PL48

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pfam15903: PL48 (This model is not part of the current CDD release)
Filopodia upregulated, FAM65
PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
Statistics
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PSSM-Id: 522089
Aligned: 13 rows
Threshold Bit Score: 588.998
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004074425   49 IIRSQSFAGFST-LQErrSRCNSFMGNSAVPKKPq--sKPKKPHlsghKGGSSSREPQPKRLEEVYNALKQGLDEYLEVH 125 
1_pfamImport    1 VRRSRSFAGFGT-PLS--RHARVSSVRSSVRSRGfs-gKSPRMP----HSSRSPVASQPEQVERVFQTLRRGLKEYLEGH 72  
Q4FZU8         17 VSRSQSFAGVLG-SQErgPRNFTVFSPPGPQRKPlvlsRVSRMFsv---ahPAPKVPQPERLDLVYAALKRGLTAYLEVH 92   Norway rat
Q1LXK2         16 ITRSQSFAGVNS-YDKs-YRSLSVFSTPGCVRKTp--sRASRMFtlstKS-PPPKVPQPERLDEVYEALKRGLQSYLQVH 90   zebrafish
XP_023811301   31 ITRSQSFTGVNS-QDKl-YRNLAVFSTPGLSRKPs---RASRMFtmstKSNAPPKVPQPERLDEIYEALKKGLQSYLHLC 105 
XP_008113820   16 INRSCSFAGFSN-AHN--RKLTKSISKGSTRSKTs--lKSAKMYps-lQKGTVIWDPKPQQVKRIFEALKKGLNDYLEMK 89  
Q96MK2         19 VGRSASFAGFSS-AQS--RRIAKSINRNSVRSRMp--aKSSKMYgt-lRKGSVCADPKPQQVKKIFEALKRGLKEYLCVQ 92   human
XP_016279347   16 MGRSSSFAGFSS-MQR--RNIVKSLNRNSMRSKVp--mKSSKIYat-lRRGTPCLDPKPQQVKKIFEALKKGLKEYLCAQ 89  
XP_003447742   16 IHRSRSFTGFSS--LT--GRQRTSSVRNSLRVKAmtgnKASRAPvsprRSSGAIWSLQPEQVDRVFQALRKGLKDYLEGH 91  
XP_005166324   35 VQRSRSFTGVNT--LG--GRRRLSSARSSLRSKAvt-gKSPRIPsn-sRAGSSVWGQQPEQVDRIFQALRKGLKDYLESH 108 
XP_009300972   16 VQRSRSFTGVNT--LG--GRRRLSSARSSLRSKAvt-gKSPRIPsnsrAGSSv-WGQQPEQVDRIFQALRKGLKDYLESH 89   zebrafish
XP_029697349   31 ITRSQSFTGVNSnDKLpy-rSLAVFSSPGLNRKPs---RASRMFtmsvKPNPPPKVPQPERLDEVYQSLKKGLQSYLQVH 106  torafugu
A9ZLX4         16 IIRSQSFAGFSG-LQErrSRCNSFIENTSALKKPq--aKVKKMHnlghKNSTTPKEPQPKRVEEVYRALKNGLDEYLEVH 92   Japanese quail
XP_004074425  126 QTELDKLMCLMKDMKRNSRLGVLYDLDKQIKSIERYMRRLEFHISKVDELYEAFCIQSRLRDGASRMKQAF-SSSPSTKG 204 
1_pfamImport   73 QAELDFLTAQQRDSKRISRLAFLYDLEKEIRALERYIRRLEFHISKVEELHEAYAIQWRLCTGAANMKRAF-ALSPSTRA 151 
Q4FZU8         93 QQEQEKLQRQIKESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKIDELYEAYCVQRRLRDGAYNMVRAYsTGSPGSRE 172  Norway rat
Q1LXK2         91 QMELDGLNRQMKESKRNSRLGFLYELDKQVKVIERFMRRLEFHLSKIDELYEAYCMQRRLRDGADKMVKAY-TASPGSRE 169  zebrafish
XP_023811301  106 QKDLDGINRQIKKSKRNSRLGFLYEQDKQVKVMERFIRRLEFHLSKVEEHHETYCLVRRLRDGADKMIKAY-TASPGSKE 184 
XP_008113820   90 QAELDYLLECHKDTRRNSRLAFYYDLDKQIRYVERYIRKLEFHISKVEELYEAYSIQCRLRDGASNMKHAF-SLSPSTKA 168 
Q96MK2         93 QAELDHLSGRHKDTRRNSRLAFYYDLDKQTRCVERHIRKMEFHISKVDELYEDYCIQCRLRDGASSMQRAF-ARCPPSRA 171  human
XP_016279347   90 QAELDYLSGRHKDTRRNSRLAFYYDLDKQTRSVERHIRKMEFHISKVEELYEGYCIQWRLRDGASNMQQAF-SLSPLTKA 168 
XP_003447742   92 QAEMDFLSSQQRETKRNSRLAFLYDLEKEIRSLERYIRRLEFQISKVEELYETYCIQWRLCQGAVNMKRAF-SLSPSTRA 170 
XP_005166324  109 QTELDFLSSQQRDTKRNSRLAFFYDLEKEIRALERYIRRLEFQISKVEELYESYCIQWRLCQGALNMKRAF-SLSPSSRQ 187 
XP_009300972   90 QTELDFLSSQQRDTKRNSRLAFFYDLEKEIRALERYIRRLEFQISKVEELYESYCIQWRLCQGALNMKRAF-SLSPSSRQ 168  zebrafish
XP_029697349  107 QMDLDNLSRQMKESKRNSRLGFLYELDKQVKVTERFIRRLEFHLSKVEELYETYCLQRRLRDGANKMVKAX-TSSPGSKE 185  torafugu
A9ZLX4         93 QTELDKLTAQLKDMRRNSRLGVLYDLDKQIKAVERYMRRLEFHISKVDELYEAYCIQRRLCDGASKMKQAF-AMSPTSKA 171  Japanese quail
XP_004074425  205 TKESIAEVNRRYKEYTENMSTFEVELENLLGEFHIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGRIEVNSRQSWDGD 284 
1_pfamImport  152 SRESLLQLGRSQRQCLEDMFMMEGELELLLGELHIKMKGLIGFARLCPGDQYEVLIRLGRQRWKLKGKIEADDRQSWDEE 231 
Q4FZU8        173 ARDSLAEATRGHREYTESMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSE 252  Norway rat
Q1LXK2        170 ARESLSEANKSFKEYTENMCMLESELENQLGEFHIKMKGLAGFARLCAGDQYEIFMKYGRQRWKLRGRIEINGKQVWDSE 249  zebrafish
XP_023811301  185 AKESLAEANKSYKEYTERMCVLENELESQLGEFHIRMKGLAGFARLCTGDQYEVLLKYGRQRWKLRGQMEMNDKQVWDGE 264 
XP_008113820  169 SRESLVELYKNLQDCTEDMCLIEGTLEVHLGEFHLKMKGLVGYARLCPGDQYEVFVRLGRQKWKLRGKILTDDSQTWDEE 248 
Q96MK2        172 ARESLQELGRSLHECAEDMWLIEGALEVHLGEFHIRMKGLVGYARLCPGDHYEVLMRLGRQRWKLKGRIESDDSQTWDEE 251  human
XP_016279347  169 SRESLVELYRNLQECTEDMCLIEGALEVHLGEFHVKMKGLVGYARICPGDQYEVFIRLGRQRWKLKGKIETDNSQTWDEE 248 
XP_003447742  171 SRESLLELNRNHRHSLQDMSTMEGELEILLGELHIKMKGLIGFARLCPGDQYEVLVRLGRQRWKIRGRIESDDSQSWDEE 250 
XP_005166324  188 SRESLLELNRNHRHSLEDMSAMEAELEILLGELHIKMKGLIGFARLCPGDQYEVLIRLGRQRWRIRGRIQTDDRQMWDEE 267 
XP_009300972  169 SRESLLELNRNHRHSLEDMSAMEAELEILLGELHIKMKGLIGFARLCPGDQYEVLIRLGRQRWRIRGRIQTDDRQMWDEE 248  zebrafish
XP_029697349  186 AKESLQKLTEDIRSYASNMCVLENDLESHLGEFHIRMKGLAGFARLCAGDQYEIFMKYGRQRWKLRGRIEINAKQVWDSE 265  torafugu
A9ZLX4        172 ARESLTEINRSYKEYTENMCTIEAELENLLGEFCIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGKIEVNGKQSWDGE 251  Japanese quail
XP_004074425  285 EMIFMPLISDLINIKVTELKGLAThMLVGSVICETKELFTAMPQVVAVDVNDLGTIKLNLEVTW---YPFDVEDLTLSSG 361 
1_pfamImport  232 EMVFLPHIQENFEIKVTEVKGLGS-VLVGVVTCESLDFFQARPHIMVVDITELGTIKLQMEVMWdpsSPFDSGETRPMST 310 
Q4FZU8        253 ETVFLPLLTEFLSIKVTELKGLANhVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIW---SPFDKDDQPSAAS 329  Norway rat
Q1LXK2        250 EMVFLPLITEFLSIKVTELKSLANhVVVGSVSCETKDLFAALPQTVAVDINDLGTIKLSLEVTW---NPFDKDDQSSSAS 326  zebrafish
XP_023811301  265 KMLFVPLIGEFLSVKVTELKSLANhVVVGNVSCDMKDLFAPLPQMVAVDINDLGTIKLSLEVNW---NPFDTEEPGGPIS 341 
XP_008113820  249 EKVFIPNLHEKFEIKVTELRGLST-LLVGVVTCDSIDFFTTRPQIIVVDITELGTIKLQLEVLW---NPFDNESVILSPG 324 
Q96MK2        252 EKAFIPTLHENLDIKVTELRGLGS-LAVGAVTCDIADFFTTRPQVIVVDITELGTIKLQLEVQW---NPFDTESFLVSPS 327  human
XP_016279347  249 EKVFIPILHEHFEIKVIELRGLST-LLVGTVTCQLEDFFTTRPQIIVVDITELGTIKLQLEVIW---NPFDTESFLVSPG 324 
XP_003447742  251 EMVFLPHIHHNFEIKVTEAKGLSW-LLVGTVTCASADFFVARPQVMLVDITELGTIKLQLEVTW---NPFDGTEKLRPLS 326 
XP_005166324  268 EMVFLPHIHGNFEIKVTEVKGLSS-ILVGMVTCRSADFFTARPQMMVVDITELGTIKLQLEVVW---NPFDSTEVRPLTA 343 
XP_009300972  249 EMVFLPHIHGNFEIKVTEVKGLSS-ILVGMVTCRSADFFTARPQMMVVDITELGTIKLQLEVVW---NPFDSTEVRPLTA 324  zebrafish
XP_029697349  266 EMVFLPLVSEFLSIKVTELKSLAShVVVGSVSCETKDLFAALPQMVAVDINDLGTIKLSLEVTW---NPFDKDEQVSTAS 342  torafugu
A9ZLX4        252 EMVFLPLIVGLISIKVTEVKGLAThILVGSVTCETKDLFAARPQVVAVDINDLGTIKLNLEITW---YPFDVEDLTPSTG 328  Japanese quail
XP_004074425  362 NLSKATALQRRVSV-YSQGTPETPTFQDNSFFMQPYP 397 
1_pfamImport  311 STSKLSVPSRKGSL-YSWTPPSTPSFTEKYFISVARR 346 
Q4FZU8        330 TVNKASTVTKRFST-YSQSPPDTPSLREQAFYNMLRR 365  Norway rat
Q1LXK2        327 TVNKAPTVNKRFST-YNQSPPDTPSLREQAFYNMLRR 362  zebrafish
XP_023811301  342 PMIKPTHDSSRFSIhVNPLPPDATSPPEQRFPKLIPN 378 
XP_008113820  325 STAKFSVGSRKNSI-YSWTPPNTPSFREKYYLSVLQP 360 
Q96MK2        328 PTGKFSMGSRKGSL-YNWTPPSTPSFRERYYLSVLQQ 363  human
XP_016279347  325 -ISKFSVGSRKGSL-YNWTPPSTPSFREKYYLSLFQQ 359 
XP_003447742  327 -GNKQSVSSRKSSV-YSWTAPSTPSFTEKYFISMVRE 361 
XP_005166324  344 SASRQSIHSRKGSV-YSWTPPNTPSFTEKYFLSMMRQ 379 
XP_009300972  325 SASRQSIHSRKGSV-YSWTPPNTPSFTEKYFLSMMRQ 360  zebrafish
XP_029697349  343 SVSRAPTVSKRFSTiFNQSPPDTPSLREQAFYNLLRH 379  torafugu
A9ZLX4        329 NVSKASALQRRMSM-YSQGTPETPTFKDHSFFRWLHP 364  Japanese quail
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