6X4H,3WSX,6FFY


Conserved Protein Domain Family
Sortilin-Vps10

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pfam15902: Sortilin-Vps10 (This model is not part of the current CDD release)
Sortilin, neurotensin receptor 3,
Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.
Statistics
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PSSM-Id: 522088
Aligned: 130 rows
Threshold Bit Score: 283.323
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6X4H_A          57 SKLYRSEDYGKNFKDITdLINNT-F-IRtefgmAIGPENSGKVVLTaevsggSR-----G-----GRIFRSSDFAKNFVQ 124  human
XP_002114766   164 TNFYRSEDNGATFARSWf-FEKI-L-IQrwdynYESPNQ---LVMI------DAr---nS-----RRIYVSRDIGKTFTT 223 
XP_002114767   151 SHFYRSTNNGAQFVKSN-FFNGK-V-VRs---wTLNGLDRLKVIF-------RDar--nP-----RTIYTTSDAGKTIST 210 
XP_003384736    95 CNVYISTDYGGTFSKINtRLQST-GpLHlytniIISPEDYRTIIIP------Hl----sQ-----GAMYISTNEGQSFTL 158 
Q9EPR5         179 SSLWRSSDFGTTYTKLTlQPGVT-T-VIdn--fYICPANKRKIILV------SSslgdrE-----QSLFLSTDEGATFQK 243  house mouse
XP_002662899   140 SSLWRSSDYGSTYTKLNlMPGTT-I-IVtn--fYICPTNKKKVILV------SSsinerD-----QMLFISTDEGASFQR 204 
25_pfamImport    1 SSLWRSADYGSTYSKV--GLGGA-V-VLts--fFICPTNKKKVVLL------GSssderD-----QLLFISTDEGSSFQR 63  
XP_040034458   249 SSLWRSSDYGSTYSKLNdKVGSR-T-VLsy--lYVCPTNKQKIMML------SDpe--vE-----SAVLISSDEGASFEK 311 
6FFY_A          65 SSLWRSSDFGTTYTKLTlQPGVTtV-IDn---fYICPANKRKIILV------SS-----SlgdreQSLFLSTDEGATFQK 129  house mouse
Q9UPU3         228 SSLWRSTDYGTTYEKLNdKVGLK-T-VLsy--lYVNPTNKRKIMLL------SDpe--mE-----SSILISSDEGATYQK 290  human
6X4H_A         125 TDLPFHPLTQ---MMYSP--QNSDYLLAL-S-TENGLWVSKNFGGKWEEIHKAVC--L---AKWG------SDNTIFFTT 186  human
XP_002114766   224 RTLDFSPAvl--rFRTDA--NIGNYVTAYdS-YTKKLYVSRDISVKWNLIDDRVR--N---FHWSta---kSGSNIYKVY 290 
XP_002114767   211 VNLPFTASt----LSYSRvaSISGYVAGY-DfTKKALYVSSNMGATWKSVATNVT--R---YSWAf------GGDDPYRI 274 
XP_003384736   159 RSFSPSTINpr-tLKFHP--TKESWFLAH-DpTTRTLYVSQNLGTSFIEISKNVN--StheYLWGnmpydaDPSTIYYNV 232 
Q9EPR5         244 YPVPFLVEm----LLFHP--KEEDKVLAY-T-KDSKLYVSSDLGKKWTLLQERVT--Kd-hVFWAv------SGVDDDPN 306  house mouse
XP_002662899   205 QPVSFTVDs----LLFHP--SEEDKLLAY-S-KEAKLYISTDLGHKWTLLQERVT--Kd-rVFWAvtg-vdVDPDLVHME 272 
25_pfamImport   64 QSVSFIPDt----LMFHP--QDQDKLLAH-C-RQGRLFVSLDLGRRWTLLQERVS--Kd-rVYWSv------PGLDLNPD 126 
XP_040034458   312 HPINFNILs----LLFHP--AQENWILAY-S-HDSKLYSSMDFGKKWQLIHDNVMpgR---FYWAvmg-ldRESDVVHIE 379 
6FFY_A         130 YPVPF----LvetLLFHP--KEEDKVLAY-T-KDSKLYVSSDLGKKWTLLQERVT--Kd-hVFWAvsg-vdDDPNLVHVE 197  house mouse
Q9UPU3         291 YRLTFYIq----sLLFHP--KQEDWVLAY-S-LDQKLYSSMDFGRRWQLMHERITpnR---FYWSvag-ldKEADLVHME 358  human
6X4H_A         187 YANGSc--KA-----DLGALELWRTSDLGKSF--KTI---G-----VK-IY--S-----FGLGGRFLFASVMA--DKDTT 239  human
XP_002114766   291 YEYL----NA-----DGFSTRIRYCNTLTMEK--GDL---D------PqMT--DaapgnLLVVGKFVMTLVND--VNTSR 346 
XP_002114767   275 YYEYTd---Y-----NRTTIRYIKTNTMAAGIfdTKM---G-----PVvPF--N-----LIVSNNYIFTLKSGsaRNSTA 331 
XP_003384736   233 DSPTDltsEV-----HLYVQKFPYTPASRTEF--DSH---F------GvHD--D-----FLMIDRYIFAQKTV--NQRA- 286 
Q9EPR5         307 LVHVEa--QD-----LSGGYRYYTCLIYNCSA--QPH---IapfsgPIdRG--S-----LTVQDEYIFLKATS--TNRT- 364  house mouse
XP_002662899   273 MQDISg--GY-----LYVTCLIQNCSDKMVTA--QFL---G-----KIdHN--S-----LSVQDEYIFVKVTT--GNRT- 325 
25_pfamImport  127 LVHMEi--QDsrgghQYVTCLVQNCSDTLVSS--RFP---G------PiDR--G-----SLCRDDYVFVKVTV--GTR-- 182 
XP_040034458   380 TRIAKg--RA-----QYVKCRAQRCTEGNRLY--LFP---G-----HVdTN--S-----LVVQDEYVFTQVTK--SGRA- 432 
6FFY_A         198 AQDLS------------GGYRYYTCLIYNCSA--QPHiapF-----SGpIDrgS-----LTVQDEYIFLKATS--TNRT- 250  house mouse
Q9UPU3         359 VRTTDg--YA-----HYLTCRIQECAETTRSG--PFA---R-----SIdIS--S-----LVVQDEYIFIQVTT--SGRA- 411  human
6X4H_A         240 RRIHVSTDqGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDrH-LYTtt----- 313  human
XP_002114766   347 PLLYVSQN-DNPFRIAHFPSSLAKRRFHVIISGSDEIIIAINHQS--NLTNLYISDESGTYFTLAIK-N-IYAasdl-ly 420 
XP_002114767   332 DLLYVSYKr-SPFRVANFPVTILNRGFLILETVDNEVVMAVNHKS--NLTNLYISDQSGAFFSRTIT-NiLTApdsswrr 407 
XP_003384736   287 -TLYVSYDr-KPFQMAHLPSELPHQNYYVASLDAKQALVIVQHTNG--QFNLYLSEEMGIYYSLSLP-DiVYGn------ 355 
Q9EPR5         365 -KYYVSYRr-SDFVLMKLPKYALPKDLQIISTDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYSLVLE-N-VRSsr----- 435  house mouse
XP_002662899   326 -KYYVSYRr-NEFVQMRFPKYSLPKDVQIVSTDENQVFLALQEWYQTDTYNLYQSDPQGVYYSIVLE-N-VRStk----- 396 
25_pfamImport  183 TRHFVSYRrG-QFVQMRFPKYSLPKDVQVVSTNEDQVFLALQEWYQSDTYNLYQSDPAGVHYALVLE-D-VRSth----- 254 
XP_040034458   433 -SYFVSYMr-ESFKRMKLPKYCLPKDMHIISTDEKQVFAAVQEWNQNNTYSLYISDSPGVYFTLSLE-D-LRTgrg---- 504 
6FFY_A         251 -KYYVSYR-RSDFVLMKLPKYALPKDLQIISTDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYSLVLE-N-VRSsr----- 321  house mouse
Q9UPU3         412 -SYYVSYRr-EAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAME-N-IKSsrg---- 483  human
6X4H_A         314 -gGe----tDFTNVTSLRGV-YITSVLSE-------DNS------IQTMITFDQGGRWTHLRKPENse-cdATAKNKNEC 373  human
XP_002114766   421 rlGys--flGFASIASMPGT-YIVSQVKRpaqgllsRPS------LVSLISFNKGGTWHPIIPPKKdr-fgNPINCRAPC 490 
XP_002114767   408 glAy----vGFYRIASLPGS-YMVSQVVG-------KAPigffppSVTKISYNKGGSWHTIKAPSTdrfgkATNCQLPAC 475 
XP_003384736   356 --Gv----lDLEIVDSMNGTtYICNQNIP-------NSA------VRTLISFDAGGNWEMLRPPTAdttgnRLECILPSC 416 
Q9EPR5         436 -qAeenvviDILEVRGVKGV-FLANQ-KV-------DGK------VTTVITYNKGRDWDYLRPPSTdmngkPTNCQPPDC 499  house mouse
XP_002662899   397 -qPeenvliDILEVRGVKGV-FLANQ-KV-------DGK------VMTLITYNKGRDWEALAPPATdmngkPVSCKQPDC 460 
25_pfamImport  255 -qPednvllDVLEVRGIKGV-FLANQ-KI-------DGK------VRTVITYNKGRDWTPLAPPPAdlngrLVACRPPDC 318 
XP_040034458   505 pgGnl--lvDFYKVEGINGM-YLANKLLD--------GH------VKTFITYNKGQTWALLPAPATdvagnNLHCILPFC 567 
6FFY_A         322 -qAeenvviDILEVRGVKGV-FLANQk--------vDGK------VTTVITYNKGRDWDYLRPPSTdmngkPTNCQPPDC 385  house mouse
Q9UPU3         484 lmGni--iiELYEVAGIKGI-FLANK-KV-------DDQ------VKTYITYNKGRDWRLLQAPDVdlrgsPVHCLLPFC 546  human
6X4H_A         374 SLHIHASYSIsqklNv-PMAPLSEPnAVGIVIA-HGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVA 451  human
XP_002114766   491 SLHLDVLTGDfl----pEAALYSSStAPGLIMG-IGNYGKELTSVdRAIYISYDGGATWVQSAHYYRIYTALNHGSIILA 565 
XP_002114767   476 SLHINFFTGVai-lN---RGVYTSNaAPGLVLG-FGSYGKVFSRAnATLYISNDGGFSWAQSSPTSNIFTALDHGSVILT 550 
XP_003384736   417 SLHLHMSSsq--ywRt---GVYSTAsAPGIIIA-HGVTGAKLNDSnVNLFISRDGGVSWNMTLKSSWGVSVLDYGGLIIA 490 
Q9EPR5         500 YLHLHLRWADnpyvSg---TVHTKDtAPGLIMG-AGNLGSQLVEYkEEMYITSDCGHTWRQVFEEEHHVLYLDHGGVIAA 575  house mouse
XP_002662899   461 HLHLHLRWADnpyvSg---TVHTKDsAPGLIMG-AGNLGSQLVEFkEEMYITADCGKTWRQVFEEEHHILYLDHGGVIVA 536 
25_pfamImport  319 HLHLHLRWADnpyvSg---TVHTKDsAPGLIMGaAGNLGSKLVEYkEEMYVSSDCGRSWRQVFEEEHHILYLDHGGVIVA 395 
XP_040034458   568 SLHLHLEMSEnpytSg---PITSKKsVPGIIVA-TGNTGTELSSTnLGMFITSDAGNSWRQIFDEEHNVWFLDNGGALLA 643 
6FFY_A         386 YLHLHLRWADn---PyvSGTVHTKDtAPGLIMG-AGNLGSQLVEYKeEMYITSDCGHTWRQVFEEEHHVLYLDHGGVIAA 461  house mouse
Q9UPU3         547 SLHLHLQLSEnpysSg---RISSKEtAPGLVVA-TGNIGPELSYTdIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVA 622  human
6X4H_A         452 IEH----SSrPINVIKFSTDEGQCWQTYTFTrDPIYFTGL 487  human
XP_002114766   566 SGRg---LQrNTVNVSYSCNSGQTFTDIQVAnLTLNTLHL 602 
XP_002114767   551 AQRg---TQrNQTFISYSCNGGKTFTNVKIAdQTMTLLTI 587 
XP_003384736   491 AQDyhqfQQtPSRRLAYSCNEGRSWSYFQFSqTNTVVFGV 530 
Q9EPR5         576 IKD----TSiPLKILKFSVDEGHTWSTHNFTsTSVFVDGL 611  house mouse
XP_002662899   537 IKD----TSiPLKILKFSIDEGRTWSIHNFTsTSVFVDGL 572 
25_pfamImport  396 IKD----TSiPLKILKFSVDEGHSWTVHNFTsTPVFVDGL 431 
XP_040034458   644 VLH----AAtPIRHLWISLDEGKKWDRHSFSlAPLYVDGV 679 
6FFY_A         462 IKD----TSiPLKILKFSVDEGHTWSTHNFTsTSVFVDGL 497  house mouse
Q9UPU3         623 MKH----TPlPVRHLWVSFDEGHSWDKYGFTsVPLFVDGA 658  human
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