Conserved Protein Domain Family
DUF4735

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pfam15882: DUF4735 (This model is not part of the current CDD release)
Domain of unknown function (DUF4735)
This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific.
Statistics
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PSSM-Id: 522075
Aligned: 24 rows
Threshold Bit Score: 228.373
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_032240389  57 DGVYGLRVAEGSLKKIL-EEFkgGKVFLSRRDFNSIRALWTRAGQISKRALPYLQKHNPAYFHRFKKQVSGP-WLEFKAF 134
EDO43038      89 SFLTFSHFFQGVLLQTL-QDP--EVQEHHPWVLHRIKGLAHRVSKLIPEILPFLQKSDRVYYQQVGFVVSKT-WSVVRRF 164
XP_002118269  61 LDAYNLLIAISAFRDITkEYFl-ENSYLSSQDVKRISEMNVAVNILFQNS---LEKFSPEYRLVFSEEVSFAa------- 129
XP_002118253  53 DSTLSFHFTKGYLRTIL-EDAsrNESLLSHNQLDRVTKLYDRFRGLIEDTAPTISQKHYQYK--FLIPLYVRnFKVPRKL 129
XP_002116852  73 DGYIGLLKAKEYLGATV-ENIdkGLSPLSTQQANQVKQIFENCSVLLIHIEAVLVNSSSSKQYDLFKMVHTP-HPIPNQL 150
XP_002118251  67 DGYFGFTGSKGFIRATI-KNYhdGLSTLNTQQINRVQQIYQRIIAVSKRIEPILANNSMAYNT-IGKIVQGS-LPVPKRL 143
XP_002118250  67 GAYYGLVRCGEYVKATL-DDYyrGLSILNVQQLNRIKQIHKRIIDVSKKIQPILAKNSQSYRQ-LHKLTQTP-ITVPEGL 143
XP_002115888  82 PSLIGLRIAQGQFEVITnDRRf-FNMTLYYDALQMYHQISRLLLADATSEATYWSKKNQKYHSSSNTLVSQP-WKLSNLD 159
EGI62344      11 DAAFGITLTEANLVAALlh---eNVQYLEDKFFIALKEMVVLSDLTRKHLMKIIAPKNETKFLMLSTLNNPNqWIKPISW 87 
XP_011265864  57 DVTYGVTLSEVNLMAALnn---dNIQYLENKFFVFLKEMLMLSDFTRRNLMNNVVPTSEIELSLQSGLNNVNlWIKPIWW 133
XP_032240389 135 R--KLD------VALIVpvnkr----esieFDEDTSDK-----CMEEM-SGTGEIKV-PCRLSDSCW-RMMMFKGAGGYT 194
EDO43038     165 R--KLN------KAPKRhl----------aFNDKKAGTqapqpCMEAL-FGSAGPGSkTCNVTDACW-TAMRRPGALGYE 224
XP_002118269 130 ---VARyingtkPSLPIsgpt-----pantFPSNMSEI-----CIATTlSGSIGSA--SCNVTEACW-NYISQPGTRMGL 193
XP_002118253 130 RklNHTyvqqsqEHS---------------VSRHYSNQ-----CLWEI-VGSWPYYRrPCNLSDICV-KFISQLHSNNYI 187
XP_002116852 151 IslRLSnvhsgaLDKDSta---------gvKFANISDM-----CLMDI-IGTRKRHQpACTFSDICW-KGITNYHARNFD 214
XP_002118251 144 VklNFTklynvsSDEILsp---------ksGYMNISDW-----CIGNI-IGSKALHVaPCTISDTCW-TGITNYHGGYYG 207
XP_002118250 144 VslNFTelhhvvLHDGSpe---------skNWENISDS-----YLHMI-SGSGNYQ--VCTITNTSW-ADITNYHTDGYI 205
XP_002115888 160 RefKLIpvqirner---------iydhgihHGNDYGMA-----CLNEL-MGQRNAM--PCTISAECW-QSNILEDLQGHK 221
EGI62344      88 T--KVFsklrshPQL-LnyqevvrsiwhgtPTETESDQ-----CLIEI-MRSSLKE--ECEIPVACVaTLIKEDDTTGYP 156
XP_011265864 134 T--RIFpknkptPNWGLsyeqviesiqhgwPNEFNSDQ-----CLFKI-MQSGLNK--KCKIPQTCTeGLIKHDNVTGYS 203
XP_032240389 195 LTHQALFLLLGETQG-CRNKLDEkikKSKSGTGL--QQVYDRICASMYPQM-VEFEKH--PNSDGRDLYMEQAMVCG-MM 267
EDO43038     225 LTHQALYFMFGEERG-CIKAFQDrlrLANEPASL--RPVYDRICADTFYQM-LALERMrgKTQQEVDLYLEMSAVCG-LL 299
XP_002118269 194 AVSQLYTDYFIRQLDyCGFKLVK---LAGGIRRL--MAVEESLCSRIYMDFkKILHNNi-SDINKAELLLQQIIICGgMF 267
XP_002118253 188 ITHQVLALSFGRQFH-CQHQIAP---LSSAFGSV--GNLEAILCSRVHKEMySSLYKGl-TNLKLQDLFTEQVDVCGsLE 260
XP_002116852 215 IIHQLFAIFVGQKLN-CTNKMNV---LAQKLGGI--ENVKAALCSRIYRQMyTNLNNAl-NKMQSWELFLAQIYICGgPA 287
XP_002118251 208 ITHQLITILNGQRLN-CTEKMNK---LAKNLGGI--QKVKEVLCTQIYYQMqKELKKGl-KNIQMQDLFLEQIFVCGgWI 280
XP_002118250 206 ITHQMLNILTGQQFN-CTEKMDK---LAKDLGGI--KKVTEVLCTQIYNEMqQELKKSl-TFVPLQDLFLEQMYTCGaWG 278
XP_002115888 222 LVRQIIYFMLAKDLK-CHAQVTQrllHHSKYHDV--NDLLQAFCSYAYLEVkTLYEQYdlKMIQAQQIFLEEIVFCA-AS 297
EGI62344     157 LTHRLLIVQVAKVLG-CEEIIDK-------TTSL--SSLVSTYCTRIFQDL-INLEAWn-FPNVTRDLMLEQVVLCG-ME 223
XP_011265864 204 LTHRLLIIQTAQRFG-CQE-----------TASLpfSYLIPAFCARIFQDL-VNLEAWn-FPNVSQDLMIEQIILCG-ME 268
XP_032240389 268 GYSRFLSKNRLKNILSWQnAK-GCYGDDEsnddrdvYdisydkgriygripqyeeisrrdikqvasaRK----LLSMKTM 342
EDO43038     300 GYSQFLSFKRMGRLLRWQmPN-GCYGDPN-------Ydall-----------------------neaGGvlyqTSHSRAT 348
XP_002118269 268 GYVEFVSIYPLHQVFKYQ-ARsGCF---------------------------------------------------KNSA 295
XP_002118253 261 FFEDFINETYVDMVLEWQ-TTqGCY-----------Mqyngty-------------------tsifpNEsngtKLAPYYS 309
XP_002116852 288 GFQKFVDAQFLSAILHWQ-SNtGCLks--------------------------------------------shSIFSSLG 322
XP_002118251 281 GYQQFLKAQYLSMMLKWQ-TKaGCF-----------Ipyygpfis---------------lhpkfnkNYtrdsSQYSSAT 333
XP_002118250 279 GYREFLNMEYLSMFLNWQ-TTaGCI-----------Aayygpfvs---------------lhpnmtkDYteddSRYLFAS 331
XP_002115888 298 GFSDFYNYNFMKEVFQYQ-SFsGCF--------------------------------------------------SMSKS 326
EGI62344     224 GYYEFVDKHYEDIILSWP-HWsGCFg----------------------------------------------vIELSNEH 256
XP_011265864 269 GYYEFLDKHYEDLILSWP-HWsGCFk----------------------------------------------lERISEKL 301
XP_032240389 343 RSLLVEKAL---------------------ED-G------CMSHITGVATGLLGVYLRWL 374
EDO43038     349 RSLLTVKEL---------------------EE-G------CESHITGVATALISVYLRWV 380
XP_002118269 296 RNRRSQRIMhlpcmlclynsvqisssleliNSrAdlasdeCNLHVSTVAFASLATSLRWW 355
XP_002118253 310 RSKRSDSTG---------------------TD-G------CHQHISSTATVLIVAHLRWL 341
XP_002116852 323 SELLPQNTLvtssd-----------hpiggIDkA------CYSRRSAAATSVLSMYLHWF 365
XP_002118251 334 DELRTNLIT---------------------PD-G------CYEHRTSVALIDVSIYLYWN 365
XP_002118250 332 DQLLIDKTIt--------------------GD--------CDQHTTAIGMSLVAAFLHLG 363
XP_002115888 327 RRKIRN------------------------IDhNekqdayCPKLKGTIFFLSSVGFIYYH 362
EGI62344     257 QITRRSSSI---------------------TDfG------CDNHTTSLAAASLAVFIREN 289
XP_011265864 302 KMTPRASSL---------------------TDfG------CNNHMTSLGAASLALFIREN 334
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